Browsing by Author "Zangerle, Robert"

Now showing items 1-6 of 6

2017-11-27Zeitschriftenartikel

Evaluating the Impact of Functional Genetic Variation on HIV-1 Control

McLaren, Paul J.; Pulit, Sara L.; Gurdasani, Deepti; Bartha, Istvan; Shea, Patrick R.; Pomilla, Cristina; Gupta, Namrata; Gkrania-Klotsas, Effrossyni; Young, Elizabeth H.; Bannert, Norbert; Amo, Julia Del; Gill, M. John; Gilmour, Jill; Kellam, Paul; Kelleher, Anthony D.; Sönnerborg, Anders; Zangerle, Robert; Post, Frank A.; Fisher, Martin; Haas, David W.; Walker, Bruce D.; Porter, Kholoud; Goldstein, David B.; Sandhu, Manjinder S.; Fellay, Jacques

Background: Previous genetic association studies of human immunodeficiency virus-1 (HIV-1) progression have focused on common human genetic variation ascertained through genome-wide genotyping. Methods: We sought ...
2019-01-08Zeitschriftenartikel

HIV-1 molecular transmission clusters in nine European countries and Canada: association with demographic and clinical factors

Paraskevis, Dimitrios; Beloukas, Apostolos; Stasinos, Kostantinos; Pantazis, Nikos; de Mendoza, Carmen; Bannert, Norbert; Meyer, Laurence; Zangerle, Robert; Gill, John; Prins, Maria; d'Arminio Montforte, Antonella; Bakken Kran, Anne-Marte; Porter, Kholoud; Touloumi, Giota

Background Knowledge of HIV-1 molecular transmission clusters (MTCs) is important, especially in large-scale datasets, for designing prevention programmes and public health intervention strategies. We used a large-scale ...
2020-09-22Zeitschriftenartikel

Human Immunodeficiency Virus Continuum of Care in 11 European Union Countries at the End of 2016 Overall and by Key Population: Have We Made Progress?

Vourli, Goergia; Noori, Teymur; Pharris, Anastasia; Porter, Kholoud; Axelsson, Maria; Begovac, Josip; Cazein, Francoise; Costagliola, Dominique; Cowan, Susan; Croxford, Sara; d'Arminio Monforte, Antonella; Delpech, Valerie; Díaz, Asunción; Giardi, Enrico; Gunsenheimer-Bartmeyer, Barbara; Hernando, Victoria; Leierer, Gisela; Lot, Florence; Nunez, Olivier; Obel, Niels; Op de Coul, Eline; Paraskeva, Dimitra; Patrinos, Stavros; Reiss, Peter; Schmid, Daniela; Sonnerborg, Anders; Suligoi, Barbara; Supervie, Virginie; van Sighem, Ard; Zangerle, Robert; Touloumi, Giota

Background. High uptake of antiretroviral treatment (ART) is essential to reduce human immunodeficiency virus (HIV) trans- mission and related mortality; however, gaps in care exist. We aimed to construct the continuum ...
2017-04-05Zeitschriftenartikel

Impact of CD4 and CD8 dynamics and viral rebounds on loss of virological control in HIV controllers

Chereau, Fanny; Madec, Yoann; Sabin, Caroline; Obel, Niels; Ruiz-Mateos, Ezequiel; Chrysos, Georgios; Fidler, Sarah; Lehmann, Clara; Zangerle, Robert; Wittkop, Linda; Reiss, Peter; Hamouda, Osamah; Perez, Vicente Estrada; Leal, Manuel; Mocroft, Amanda; Olalla, Patricia Garcia De; Ammassari, Adriana; Monforte, Antonella D'Arminio; Mussini, Cristina; Segura, Ferran; Castagna, Antonella; Cavassini, Matthias; Grabar, Sophie; Meyer, Laurence

Objective: HIV controllers (HICs) spontaneously maintain HIV viral replication at low level without antiretroviral therapy (ART), a small number of whom will eventually lose this ability to control HIV viremia. The ...
2013-11-14Zeitschriftenartikel

Symptomatic Illness and Low CD4 Cell Count at HIV Seroconversion as Markers of Severe Primary HIV Infection

Lodi, Sara; Fisher, Martin; Phillips, Andrew; Luca, Andrea de; Ghosn, Jade; Malyuta, Ruslan; Zangerle, Robert; Moreno, Santiago; Vanhems, Philippe; Boufassa, Faroudy; Guiguet, Marguerite; Porter, Kholoud

Background: The risk/benefit of initiating ART in primary HIV infection (PHI) is unclear. The benefits are more likely to outweigh the risks in patients with severe PHI. An accepted definition of severe PHI is, however, ...
2013-07-30Zeitschriftenartikel

Virologic and Immunologic Response to cART by HIV-1 Subtype in the CASCADE Collaboration

Touloumi, Giota; Pantazis, Nikos; Chaix, Marie-Laure; Bucher, Heiner C.; Zangerle, Robert; Kran, Anne-Marte Bakken; Thiebaut, Rodolphe; Masquelier, Bernard; Kücherer, Claudia; Monforte, Antonella d'Arminio; Meyer, Laurence; Porter, Kholoud

Background: We aimed to compare rates of virologic response and CD4 changes after combination antiretroviral (cART) initiation in individuals infected with B and specific non-B HIV subtypes. Methods: Using CASCADE ...