Browsing by Author "Lam, Kwok-ho"

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2023-01-18Zeitschriftenartikel

Crystal structures of OrfX1, OrfX2 and the OrfX1–OrfX3 complex from the orfX gene cluster of botulinum neurotoxin E1

Gao, Linfeng; Lam, Kwok-ho; Liu, Shun; Przykopanski, Adina; Lübke, Johanna; Qi, Ruifeng; Krüger, Maren; Nowakowska, Maria B.; Selby, Katja; Douillard, François P.; Dorner, Martin B.; Perry, Kay; Linström, Miia; Dorner, Brigitte G.; Rummel, Andreas; Jin, Rongsheng

Botulinum neurotoxins (BoNTs) are among the most lethal toxins known to humans, comprising seven established serotypes termed BoNT/A–G encoded in two types of gene clusters (ha and orfX) in BoNT-producing clostridia. The ...
2016-06-13Zeitschriftenartikel

N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A

Yao, Guorui; Zhang, Sicai; Mahrhold, Stefan; Lam, Kwok-ho; Stern, Daniel; Bagramyan, Karine; Perry, Kay; Kalkum, Markus; Rummel, Andreas; Dong, Min; Jin, Rongsheng

Botulinum neurotoxin serotype A1 (BoNT/A1), a licensed drug widely used for medical and cosmetic applications, exerts its action by invading motoneurons. Here we report a 2.0-Å-resolution crystal structure of the BoNT/A1 ...