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Browsing by Author "Niemann, Heiner"
Now showing items 1-4 of 4
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2011-04-29ZeitschriftenartikelDevelopment of sensitive methods for detection of porcine endogenous retrovirus-C (PERV-C) in the genome of pigs Kaulitz, Danny; Mihica, Debora; Dorna, Jens; Costa, Michael Rodrigues; Petersen, Björn; Niemann, Heiner; Tönjes, Ralf R.; Denner, JoachimPorcine endogenous retroviruses (PERV) represent a risk for xenotransplantation using pig cells, tissues or organs. PERV-A and PERV-B are present in the genome of all pigs and both infect human cells in vitro. PERV-C infects ...
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2009-04-22ZeitschriftenartikelDistribution and expression of porcine endogenous retroviruses in multi-transgenic pigs generated for xenotransplantation Dieckhoff, Britta; Kessler, Barbara; Jobst, Danny; Kues, Wilfried A.; Petersen, Björn; Pfeifer, Alexander; Kurth, Reinhard; Niemann, Heiner; Wolf, Eckhard; Denner, JoachimBackground: Multi-transgenic pigs produced for use in xenotransplantation have to be screened for the presence and expression of porcine endogenous retroviruses (PERV) to select animals with low PERV load. The production ...
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2016-06-29ZeitschriftenartikelEfficient production of multi-modified pigs for xenotransplantation by ‘combineering’, gene stacking and gene editing Fischer, Konrad; Kraner-Scheiber, Simone; Petersen, Björn; Rieblinger, Beate; Buermann, Anna; Flisikowska, Tatiana; Flisikowski, Krzysztof; Christan, Susanne; Edlinger, Marlene; Baars, Wiebke; Kurome, Mayuko; Zakhartchenko, Valeri; Kessler, Barbara; Plotzki, Elena; Szczerbal, Izabela; Switonski, Marek; Denner, Joachim; Wolf, Eckhard; Schwinzer, Reinhard; Niemann, Heiner; Kind, Alexander; Schnieke, AngelikaXenotransplantation from pigs could alleviate the shortage of human tissues and organs for transplantation. Means have been identified to overcome hyperacute rejection and acute vascular rejection mechanisms mounted by the ...
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2008-03-10ZeitschriftenartikelKnockdown of porcine endogenous retrovirus (PERV) expression by PERV-specific shRNA in transgenic pigs Dieckhoff, Britta; Petersen, Björn; Kues, Wilfried A.; Kurth, Reinhard; Niemann, Heiner; Denner, JoachimBackground: Xenotransplantation using porcine cells, tissues or organs may be associated with the transmission of porcine endogenous retroviruses (PERVs). More than 50 viral copies have been identified in the pig genome ...