Browsing by Author "Abt, Marion"

Now showing items 1-2 of 2

2011-05-31Zeitschriftenartikel

Improvement of H5N1 influenza vaccine viruses: Influence of internal gene segments of avian and human origin on production and hemagglutinin content

Abt, Marion; Jonge, Jørgen de; Laue, Michael; Wolff, Thorsten

The H5N1-clade 1 influenza vaccine strain NIBRG-14 produces exceptionally low amounts of antigen, a problem recently encountered also for initial pandemic H1N1-2009 vaccine seeds. Here, we report on a strategy that may ...
2011-11-18Zeitschriftenartikel

Synergistic Adaptive Mutations in the Hemagglutinin and Polymerase Acidic Protein Lead to Increased Virulence of Pandemic 2009 H1N1 Influenza A Virus in Mice

Seyer, Roman; Hrincius, Eike R.; Ritzel, Dorothea; Abt, Marion; Mellmann, Alexander; Marjuki, Henju; Kühn, Joachim; Wolff, Thorsten; Ludwig, Stephan; Ehrhardt, Christina

Influenza impressively reflects the paradigm of a viral disease in which continued evolution of the virus is of paramount importance for annual epidemics and occasional pandemics in humans. Because of the continuous threat ...