2021-10-12Zeitschriftenartikel
Knock-In Mice Expressing a 15-Lipoxygenating Alox5 Mutant Respond Differently to Experimental Inflammation Than Reported Alox5−/− Mice
Marbach-Breitrück, Eugenia; Rohwer, Nadine; Infante-Duarte, Carmen; Romero-Suarez, Silvina; Labuz, Dominika; Machelska, Halina; Kutzner, Laura; Schebb, Nils Helge; Rothe, Michael; Reddanna, Pallu; Weylandt, Karsten H.; Wieler, Lothar H.; Heydeck, Dagmar; Kuhn, Hartmut
Arachidonic acid 5-lipoxygenase (ALOX5) is the key enzyme in the biosynthesis of pro-
inflammatory leukotrienes. We recently created knock-in mice (Alox5-KI) which express an arachi-
donic acid 15-lipoxygenating Alox5 ...
