Browsing by Author "Radbruch, Andreas"

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2016-12-30Zeitschriftenartikel

Adequate immune response ensured by binary IL-2 and graded CD25 expression in a murine transfer model

Fuhrmann, Franziska; Lischke, Timo; Gross, Fridolin; Scheel, Tobias; Bauer, Laura; Kalim, Khalid Wasim; Radbruch, Andreas; Herzel, Hanspeter; Hutloff, Andreas; Baumgrass, Ria

The IL-2/IL-2Ralpha (CD25) axis is of central importance for the interplay of effector and regulatory T cells. Nevertheless, the question how different antigen loads are translated into appropriate IL-2 production to ensure ...
2003-01-01Zeitschriftenartikel

Expression of ICOS In Vivo Defines CD4+ Effector T Cells with High Inflammatory Potential and a Strong Bias for Secretion of Interleukin 10

Löhning, Max; Hutloff, Andreas; Kallinich, Tilmann; Mages, Hans Werner; Bonhagen, Kerstin; Radbruch, Andreas; Hamelmann, Eckard; Kroczek, Richard

The studies performed to date analyzed the overall participation of the inducible costimulator (ICOS) in model diseases, but did not yield information on the nature and function of ICOS-expressing T cells in vivo. We ...