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Browsing by Author "Hohn, Oliver"
Now showing items 1-13 of 13
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2010-07-01ZeitschriftenartikelAbsence of evidence of Xenotropic Murine Leukemia Virus-related virus infection in persons with Chronic Fatigue Syndrome and healthy controls in the United States Switzer, William M; Jia, Hongwei; Hohn, Oliver; Zheng, HaoQiang; Tang, Shaohua; Shankar, Anupama; Bannert, Norbert; Simmons, Graham; Hendry, R Michael; Falkenberg, Virginia R; Reeves, William C; Heneine, WalidBackground: XMRV, a xenotropic murine leukemia virus (MuLV)-related virus, was recently identified by PCR testing in 67% of persons with chronic fatigue syndrome (CFS) and in 3.7% of healthy persons from the United States. ...
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2014-12-02ZeitschriftenartikelCMV-Promoter Driven Codon-Optimized Expression Alters the Assembly Type and Morphology of a Reconstituted HERV-K(HML-2) Hohn, Oliver; Hanke, Kirsten; Lausch, Veronika; Zimmermann, Anja; Mostafa, Saeed; Bannert, NorbertThe HERV-K(HML-2) family contains the most recently integrated and best preserved endogenized proviral sequences in the human genome. All known elements have nevertheless been subjected to mutations or deletions that render ...
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2012-12-01ZeitschriftenartikelHER2/neu DNA vaccination by intradermal gene delivery in a mouse tumor model Gene gun is superior to jet injector in inducing CTL responses and protective immunityNguyen-Hoai, Tam; Kobelt, Dennis; Hohn, Oliver; Vu, Minh D.; Schlag, Peter M.; Dörken, Bernd; Norley, Stephen; Lipp, Martin; Walther, Wolfgang; Pezzutto, Antonio; Westermann, JörgDNA vaccines are potential tools for the induction of immune responses against both infectious disease and cancer. The dermal application of DNA vaccines is of particular interest since the epidermal and dermal layers of ...
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2013-09-20ZeitschriftenartikelHERV-K(HML-2), the best preserved family of HERVs: endogenization, expression, and implications in health and disease Hohn, Oliver; Hanke, Kirsten; Bannert, NorbertRetroviruses that have the ability to infect germ line cells can become an integral and inherited part of the host genome. About 8% of the human chromosomal DNA consists of sequences derived from infections by retroviruses ...
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2018-02-13ZeitschriftenartikelHERVs New Role in Cancer: From Accused Perpetrators to Cheerful Protectors Bannert, Norbert; Hofmann, Henning; Block, Adriana; Hohn, OliverInitial indications that retroviruses are connected to neoplastic transformation were seen more than a century ago. This concept has also been tested for endogenized retroviruses (ERVs) that are abundantly expressed in ...
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2011-05-09ZeitschriftenartikelIdentification of the protease cleavage sites in a reconstituted Gag polyprotein of an HERV-K(HML-2) element George, Maja; Schwecke, Torsten; Beimforde, Nadine; Hohn, Oliver; Chudak, Claudia; Zimmermann, Anja; Kurth, Reinhard; Naumann, Dieter; Bannert, NorbertBackground: The human genome harbors several largely preserved HERV-K(HML-2) elements. Although this retroviral family comes closest of all known HERVs to producing replication competent virions, mutations acquired during ...
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2009-10-16ZeitschriftenartikelLack of evidence for xenotropic murine leukemia virus-related virus(XMRV) in German prostate cancer patients Hohn, Oliver; Krause, Hans; Barbarotto, Pia; Niederstadt, Lars; Beimforde, Nadine; Denner, Joachim; Miller, Kurt; Kurth, Reinhard; Bannert, NorbertBackground: A novel gammaretrovirus named xenotropic murine leukemia virus-related virus (XMRV) has been recently identified and found to have a prevalence of 40% in prostate tumor samples from American patients carrying ...
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2011-10-12ZeitschriftenartikelNo Detection of XMRV in Blood Samples and Tissue Sections from Prostate Cancer Patients in Northern Europe. Stieler, Kristin; Schindler, Sarah; Schlomm, Thorsten; Hohn, Oliver; Bannert, Norbert; Simon, Ronald; Minner, Sarah; Schindler, Michael; Fischer, NicoleBackground: We recently published the rare detection of xenotropic murine leukemia virus-related virus (XMRV) (1/105) in prostate cancer (PCA) tissue of patients in Northern Europe by PCR. The controversial discussion ...
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2010-12-22ZeitschriftenartikelNo Evidence for XMRV in German CFS and MS Patients with Fatigue Despite the Ability of the Virus to Infect Human Blood Cells In Vitro Hohn, Oliver; Strohschein, Kristin; Brandt, Alexander U.; Seeher, Sandra; Klein, Sandra; Kurth, Reinhard; Paul, Friedemann; Meisel, Christian; Scheibenbogen, Carmen; Bannert, NorbertBackground: Xenotropic murine leukemia virus-related virus (XMRV), a novel human retrovirus originally identified in prostate cancer tissues, has recently been associated with chronic fatigue syndrome (CFS), a disabling ...
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2017-08-22ZeitschriftenartikelNo significant HTLV seroprevalence in German people who inject drugs Hohn, Oliver; Norley, Stephen; Kücherer, Claudia; Bazarbachi, Ali; Hajj, Hiba El; Marcus, Ulrich; Zimmermann, Ruth; Bannert, NorbertBackground: Although human T-lymphotropic virus (HTLV) is transmitted via the same routes as human immunodeficiency virus (HIV), its worldwide seroprevalence differs drastically because HTLV is transmitted mainly via ...
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2011-07-27ZeitschriftenartikelOrigin of XMRV and its Demise as a Human Pathogen Associated with Chronic Fatigue Syndrome Hohn, Oliver; Bannert, NorbertRetroviruses are well known pathogens of mammals, birds and fish. Their potential to induce cancer in chickens was already described almost 100 years ago and murine retroviruses have been a subject of study for 50 years. ...
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2012-05-11ZeitschriftenartikelStimulation of IgY responses in gene gun immunized laying hens by combined administration of vector DNA coding for the target antigen Botulinum toxin A1 and for avian cytokine adjuvants Niederstadt, Lars; Hohn, Oliver; Dorner, Brigitte; Schade, Rüdiger; Bannert, NorbertDNA immunization is a convenient and effective way of inducing a specific antibody response. In mammals, co-administration of vectors encoding immunostimulatory cytokines can enhance the humoral response resulting in ...
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2010-06-01ZeitschriftenartikelXenotropic Murine Leukemia Virus–related Gammaretrovirus in Respiratory Tract Fischer, Nicole; Schulz, Claudia; Stieler, Kristin; Hohn, Oliver; Lange, Christoph; Drosten, Christian; Aepfelbacher, MartinXenotropic murine leukemia virus–related gammaretrovirus (XMRV) has been recently associated with prostate cancer and chronic fatigue syndrome. To identify nucleic acid sequences, we examined respiratory secretions by using ...