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Auflistung nach Autor "Beekes, Michael"
Anzeige der Publikationen 21-28 von 28
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2006-12-21ZeitschriftenartikelPropagation of scrapie in peripheral nerves after footpad infection in normal and neurotoxin exposed hamsters Kratzel, Christine; Mai, Jessica; Madela, Kazimierz; Beekes, Michael; Krüger, DominiqueAs is known from various animal models, the spread of agents causing transmissible spongiform encephalopathies (TSE) after peripheral infection affects peripheral nerves before reaching the central nervous system (CNS) and ...
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2011-05-27ZeitschriftenartikelQuantitative detection and biological propagation of scrapie seeding activity in vitro facilitate use of prions as model pathogens for disinfection. Pritzkow, Sandra; Wagenführ, Katja; Daus, Martin L.; Boerner, Susann; Lemmer, Karin; Thomzig, Achim; Mielke, Martin; Beekes, MichaelPrions are pathogens with an unusually high tolerance to inactivation and constitute a complex challenge to the re-processing of surgical instruments. On the other hand, however, they provide an informative paradigm which ...
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2007-09-25ZeitschriftenartikelRelevance of the regional lymph node in scrapie pathogenesis after peripheral infection of hamsters Kratzel, Christine; Krüger, Dominique; Beekes, MichaelBackground: The exact role of the lymphoreticular system in the spread of peripheral prion infections to the central nervous system still needs further elucidation. Against this background, the influence of the regional ...
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2016-09-09ZeitschriftenartikelReversible off and on switching of prion infectivity via removing and reinstalling prion sialylation Katorcha, Elizaveta; Daus, Martin L.; Gonzalez-Montalban, Nuria; Makarava, Natallia; Lasch, Peter; Beekes, Michael; Baskakov, Ilia V.The innate immune system provides the first line of defense against pathogens. To recognize pathogens, this system detects a number of molecular features that discriminate pathogens from host cells, including terminal ...
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2007-05-09ZeitschriftenartikelScrapie Agent (Strain 263K) Can Transmit Disease via the Oral Route after Persistence in Soil over Years Seidel, Bjoern; Thomzig, Achim; Buschmann, Anne; Groschup, Martin H.; Peters, Rainer; Beekes, Michael; Terytze, KonstantinThe persistence of infectious biomolecules in soil constitutes a substantial challenge. This holds particularly true with respect to prions, the causative agents of transmissible spongiform encephalopathies (TSEs) such as ...
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2010-06-30ZeitschriftenartikelSonstige transmissible spongiforme Enzephalopathien (TSE) bei Tieren Beekes, MichaelNeben der Bovinen spongiformen Enzephalopathie (BSE) bei Rindern ( → Kapitel VIII – 4.2.1) , der Scrapie (Traberkrankheit) bei Schafen und Ziegen ( → Kapitel VIII – 4.2.2) und der chronisch auszehrenden Krankheit ...
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2021-07-18ZeitschriftenartikelThe Neural Gut–Brain Axis of Pathological Protein Aggregation in Parkinson’s Disease and Its Counterpart in Peroral Prion Infections Beekes, MichaelA neuropathological hallmark of Parkinson’s disease (PD) is the cerebral deposition of abnormally aggregated α-synuclein (αSyn). PD-associated αSyn (αSynPD) aggregates are assumed to act, in a prion-like manner, as ...
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2013-03-11ZeitschriftenartikelTowards further reduction and replacement of animal bioassays in prion research by cell and protein misfolding cyclic amplification assays Boerner, Susann; Wagenführ, Katja; Daus, Martin L.; Thomzig, Achim; Beekes, MichaelLaboratory animals have long since been used extensively in bioassays for prions in order to quantify, usually in terms of median infective doses [ID50], how infectious these pathogens are in vivo. The identification of ...