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Auflistung nach Autor "Krüger, Maren"
Anzeige der Publikationen 1-7 von 7
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2022-02-02ZeitschriftenartikelConstruction and validation of safe Clostridium botulinum Group II surrogate strain producing inactive botulinum neurotoxin type E toxoid Nowakowska, Maria B.; Selby, Katja; Przykopanski, Adina; Krüger, Maren; Krez, Nadja; Dorner, Brigitte G.; Dorner, Martin B.; Jin, Rongsheng; Minton, Nigel P.; Rummel, Andreas; Lindström, MiiaBotulinum neurotoxins (BoNTs), produced by the spore-forming bacterium Clostridium botulinum, cause botulism, a rare but fatal illness affecting humans and animals. Despite causing a life-threatening disease, BoNT is a ...
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2023-01-18ZeitschriftenartikelCrystal structures of OrfX1, OrfX2 and the OrfX1–OrfX3 complex from the orfX gene cluster of botulinum neurotoxin E1 Gao, Linfeng; Lam, Kwok-ho; Liu, Shun; Przykopanski, Adina; Lübke, Johanna; Qi, Ruifeng; Krüger, Maren; Nowakowska, Maria B.; Selby, Katja; Douillard, François P.; Dorner, Martin B.; Perry, Kay; Linström, Miia; Dorner, Brigitte G.; Rummel, Andreas; Jin, RongshengBotulinum neurotoxins (BoNTs) are among the most lethal toxins known to humans, comprising seven established serotypes termed BoNT/A–G encoded in two types of gene clusters (ha and orfX) in BoNT-producing clostridia. The ...
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2017-07-11ZeitschriftenartikelHighly sensitive sandwich immunoassay and immunochromatographic test for the detection of Clostridial epsilon toxin in complex matrices Féraudet-Tarisse, Cécile; Mazuet, Christelle; Pauillac, Serge; Krüger, Maren; Lacroux, Caroline; Popoff, Michel R.; Dorner, Brigitte; Andréoletti, Olivier; Plaisance, Marc; Volland, Hervé; Simon, StéphanieEpsilon toxin is one of the four major toxins of Clostridium perfringens. It is the third most potent clostridial toxin after botulinum and tetanus toxins and is thus considered as a potential biological weapon classified ...
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2021-04-08ZeitschriftenartikelInnovative and Highly Sensitive Detection of Clostridium perfringens Enterotoxin Based on Receptor Interaction and Monoclonal Antibodies Neumann, Thea; Krüger, Maren; Weisemann, Jasmin; Mahrhold, Stefan; Stern, Daniel; Dorner, Martin B.; Feraudet-Tarisse, Cécile; Pöhlmann, Christopher; Schulz, Katharina; Messelhäußer, Ute; Rimek, Dagmar; Gessler, Frank; Elßner, Thomas; Simon, Stéphanie; Rummel, Andreas; Dorner, Brigitte G.Clostridium perfringens enterotoxin (CPE) regularly causes food poisoning and antibioticassociated diarrhea; therefore, reliable toxin detection is crucial. To this aim, we explored stationary and mobile strategies to ...
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2022-04-14ZeitschriftenartikelMALDI-TOF-MS-Based Identification of Monoclonal Murine Anti-SARS-CoV-2 Antibodies within One Hour Tscheuschner, Georg; Kaiser, Melanie N.; Lisec, Jan; Beslic, Denis; Muth, Thilo; Krüger, Maren; Mages, Hans Werner; Dorner, Brigitte G.; Knospe, Julia; Schenk, Jörg A.; Sellrie, Frank; Weller, Michael G.During the SARS-CoV-2 pandemic, many virus-binding monoclonal antibodies have been developed for clinical and diagnostic purposes. This underlines the importance of antibodies as universal bioanalytical reagents. However, ...
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2021-12-20ZeitschriftenartikelPreclinical evaluation of a candidate naked plasmid DNA vaccine against SARS-CoV-2 Lassaunière, Ria; Polacel, Charlotta; Gram, Gregers J.; Frische, Anders; Tingstedt, Jeanette Linnea; Krüger, Maren; Dorner, Brigitte G.; Cook, Anthony; Brown, Renita; Orekov, Tatyana; Putmon-Taylor, Tammy; Campbell, Tracey-Ann; Greenhouse, Jack; Pessaint, Laurent; Andersen, Hanne; Lewis, Mark G.; Fomsgaard, AndersNew generation plasmid DNA vaccines may be a safe, fast and simple emergency vaccine platform for preparedness against emerging viral pathogens. Applying platform optimization strategies, we tested the pre-clinical ...
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2021-05-25ZeitschriftenartikelStrengthening the United Nations Secretary-General’s Mechanism to an alleged use of bioweapons through a quality-assured laboratory response Appelt, Sandra; Rohleder, Anna-Maria; Ivernizzi, Cédric; Mikulak, Robert; Brinkmann, Annika; Nitsche, Andreas; Krüger, Maren; Dorner, Martin B.; Dorner, Brigitte G.; Scholz, Holger C.; Grunow, RolandThe cascade of innovations in biotechnology opens new pathways for biological warfare. The international laboratory network being developed under the UN Secretary-General’s Mechanism could provide vital evidence in case ...