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Auflistung nach Autor "Brinkmann, Annika"
Anzeige der Publikationen 1-20 von 29
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2019-01-11ZeitschriftenartikelA cross-sectional screening by next-generation sequencing reveals Rickettsia, Coxiella, Francisella, Borrelia, Babesia, Theileria and Hemolivia species in ticks from Anatolia Brinkmann, Annika; Hekimoğlu, Olcay; Dinçer, Ender; Hagedorn, Peter; Nitsche, Andreas; Ergünay, KorayBackground Ticks participate as arthropod vectors in the transmission of pathogenic microorganisms to humans. Several tick-borne infections have reemerged, along with newly described agents of unexplored pathogenicity. ...
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2022-08-15ZeitschriftenartikelAdvancing Precision Vaccinology by Molecular and Genomic Surveillance of Severe Acute Respiratory Syndrome Coronavirus 2 in Germany, 2021 Oh, Djin-Ye; Hölzer, Martin; Paraskevopolou, Sofia; Tofimova, Maria; Hartkopf, Felix; Budt, Matthias; Wedde, Marianne; Richard, Hugues; Haldemann, Berit; Domaszewska, Teresa; Reiche, Janine; Keeren, Kathrin; Radonić, Aleksander; Ramos Calderón, Julia Patricia; Smith, Maureen Rebecca; Brinkmann, Annika; Trappe, Kathrin; Drechsel, Oliver; Klaper, Kathleen; Hein, Sascha; Hildt, Eberhardt; Haas, Walter; Calvignac-Spencer, Sébastien; Semmler, Torsten; Dürrwald, Ralf; Thürmer, Andrea; Drosten, Christian; Fuchs, Stephan; Kröger, Stefan; von Kleist, Max; Wolff, Thorsten; Integrated Molecular Surveillance for SARS-CoV-2 (IMS-SC2) Laboratory NetworkBackground Comprehensive pathogen genomic surveillance represents a powerful tool to complement and advance precision vaccinology. The emergence of the Alpha variant in December 2020 and the resulting efforts to track ...
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2021-07-01ZeitschriftenartikelAmpliCoV: Rapid Whole-Genome Sequencing Using Multiplex PCR Amplification and Real-Time Oxford Nanopore MinION Sequencing Enables Rapid Variant Identification of SARS-CoV-2 Brinkmann, Annika; Ulm, Sophie-Luisa; Uddin, Steven; Förster, Sophie; Seifert, Dominique; Oehme, Rainer; Corty, Merle; Schaade, Lars; Michel, Janine; Nitsche, AndreasSince the emergence of the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) in December 2019, the scientific community has been sharing data on epidemiology, diagnostic methods, and whole-genomic sequences ...
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2022-11-17ZeitschriftenartikelAnalysis of two choir outbreaks acting in concert to characterize long- range transmission risks through SARS-CoV-2, Berlin, Germany, 2020 Reichert, Felix; Stier, Oliver; Hartmann, Anne; Ruscher, Claudia; Brinkmann, Annika; Grossegesse, Marica; Neumann, Markus; Werber, Dirk; Hausner, Marius; Kunze, Mareike; Weiß, Bettina; Michel, Janine; Nitsche, Andreas; an der Heiden, Matthias; Kriegel, Martin; Corman, Victor Max; Jones, Terry Carleton; Drosten, Christian; Brommann, Tobias; Buchholz, UdoBackground Superspreading events are important drivers of the SARS-CoV-2 pandemic and long-range (LR) transmission is believed to play a major role. We investigated two choir outbreaks with different attack rates (AR) ...
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2019-05-06ZeitschriftenartikelArboviral screening of invasive Aedes species in northeastern Turkey: West Nile virus circulation and detection of insect-only viruses Akıner, Mustafa M.; Öztürk, Murat; Buğra Başer, Aykut; Günay, Filiz; Hacıoğlu, Sabri; Brinkmann, Annika; Emanet, Nergis; Alten, Bülent; Özkul, Aykut; Nitsche, Andreas; Linton, Yvonne-Marie; Ergünay, KorayBackground The recent reports of Aedes aegypti and Ae. albopictus populations in Turkey, in parallel with the territorial expansion identified in several surrounding countries, have raised concerns about the establishment ...
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2017-03-20ZeitschriftenartikelCo-circulation of West Nile virus and distinct insect-specific flaviviruses in Turkey Ergünay, Koray; Litzba, Nadine; Brinkmann, Annika; Günay, Filiz; Sarıkaya, Yasemen; Kar, Sırrı; Örsten, Serra; Öter, Kerem; Domingo, Cristina; Kasap, Özge Erisoz; Özkul, Aykut; Mitchell, Luke; Nitsche, Andreas; Alten, Bülent; Linton, Yvonne-MarieBackground: Active vector surveillance provides an efficient tool for monitoring the presence or spread of emerging or re-emerging vector-borne viruses. This study was undertaken to investigate the circulation of ...
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2017-11-20ZeitschriftenartikelDevelopment and preliminary evaluation of a multiplexed amplification and next generation sequencing method for viral hemorrhagic fever diagnostics Brinkmann, Annika; Ergünay, Koray; Radonić, Aleksandar; Tufan, Zeliha Kocak; Domingo, Cristina; Nitsche, AndreasBackground: We describe the development and evaluation of a novel method for targeted amplification and Next Generation Sequencing (NGS)-based identification of viral hemorrhagic fever (VHF) agents and assess the ...
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2019-09-04ZeitschriftenartikelEffects of Regular Kefir Consumption on Gut Microbiota in Patients with Metabolic Syndrome: A Parallel-Group, Randomized, Controlled Study Bellikci-Koyu, Ezgi; Sarer-Yurekli, Banu Pınar; Akyon, Yakut; Aydin-Kose, Fadime; Karagozlu, Cem; Ozgen, Ahmet Gokhan; Brinkmann, Annika; Nitsche, Andreas; Ergunay, Koray; Yilmaz, Engin; Buyuktuncer, ZehraSeveral health-promoting effects of kefir have been suggested, however, there is limited evidence for its potential effect on gut microbiota in metabolic syndrome This study aimed to investigate the effects of regular kefir ...
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2022-11-10ZeitschriftenartikelEvaluation of 11 commercially available PCR kits for the detection of monkeypox virus DNA, Berlin, July to September 2022 Michel, Janine; Targosz, Angelina; Rinner, Thomas; Bourquain, Daniel; Brinkmann, Annika; Sacks, Jilian Amber; Schaade, Lars; Nitsche, AndreasBefore the international spread of monkeypox in May 2022, PCR kits for the detection of orthopoxviruses, and specifically monkeypox virus, were rarely available. Here we describe the evaluation of 11 recently developed ...
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2020-12-24ZeitschriftenartikelFirst detection of bat-borne Issyk-Kul virus in Europe Brinkmann, Annika; Kohl, Claudia; Radonić, Aleksandar; Dabrowski, Piotr Wojtek; Mühldorfer, Kristin; Nitsche, Andreas; Wibbelt, Gudrun; Kurth, AndreasBats have been gaining attention as potential reservoir hosts of numerous viruses pathogenic to animals and man. Issyk-Kul virus, a member of the family Nairoviridae, was first isolated in the 1970s from vespertilionid ...
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2017-07-14ZeitschriftenartikelGeneric amplification and next generation sequencing reveal Crimean-Congo hemorrhagic fever virus AP92-like strain and distinct tick phleboviruses in Anatolia, Turkey Dinçer, Ender; Brinkmann, Annika; Hekimoğlu, Olcay; Hacıoğlu, Sabri; Földes, Katalin; Karapınar, Zeynep; Polat, Pelin Fatoş; Oğuz, Bekir; Kılınç, Özlem Orunç; Hagedorn, Peter; Özer, Nurdan; Özkul, Aykut; Nitsche, Andreas; Ergünay, KorayBackground: Ticks are involved with the transmission of several viruses with significant health impact. As incidences of tick-borne viral infections are rising, several novel and divergent tick- associated viruses have ...
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2022-05-03ZeitschriftenartikelGenomic Sequencing and Analysis of a Novel Human Cowpox Virus With Mosaic Sequences From North America and Old World Orthopoxvirus Diaz-Cánova, Diana; Moens, Ugo L.; Brinkmann, Annika; Nitsche, Andreas; Okeke, Malachy IfeanyiOrthopoxviruses (OPXVs) not only infect their natural hosts, but some OPXVs can also cause disease in humans. Previously, we partially characterized an OPXV isolated from an 18-year-old male living in Northern Norway. ...
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2012-08-14ZeitschriftenartikelIsolation and characterization of three Mammalian orthoreoviruses from European bats. Kohl, Claudia; Lesnik, René; Brinkmann, Annika; Ebinger, Arnt; Radonić, Aleksandar; Nitsche, Andreas; Mühldorfer, Kristin; Wibbelt, Gudrun; Kurth, AndreasIn recent years novel human respiratory disease agents have been described in South East Asia and Australia. The causative pathogens were classified as pteropine orthoreoviruses with strong phylogenetic relationship to ...
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2020-11-25ZeitschriftenartikelMetagenomics-Based Proficiency Test of Smoked Salmon Spiked with a Mock Community Sala, Claudia; Mordhorst, Hanne; Grützke, Josephine; Brinkmann, Annika; Petersen, Thomas N.; Poulsen, Casper; Cotter, Paul D.; Crispie, Fiona; Ellis, Richard J.; Castellani, Gastone; Amid, Clara; Hakhverdyan, Mikhayil; Le Guyader, Soizick; Manfreda, Gerardo; Mossong, Joël; Nitsche, Andreas; Ragimbeau, Catherine; Schaeffer, Julien; Schlundt, Joergen; Tay, Moon Y. F.; Aarestrup, Frank M.; Hendriksen, Rene S.; Pamp, Sünje Johanna; De Cesare, AlessandraAn inter-laboratory proficiency test was organized to assess the ability of participants to perform shotgun metagenomic sequencing of cold smoked salmon, experimentally spiked with a mock community composed of six bacteria, ...
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2012-06-21ZeitschriftenartikelNovel paramyxoviruses in free-ranging European bats. Kurth, Andreas; Kohl, Claudia; Brinkmann, Annika; Ebinger, Arnt; Harper, Jennifer A.; Wang, Lin-Fa; Mühldorfer, Kristin; Wibbelt, GudrunThe zoonotic potential of paramyxoviruses is particularly demonstrated by their broad host range like the highly pathogenic Hendra and Nipah viruses originating from bats. But while so far all bat-borne paramyxoviruses ...
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2019-08-01ZeitschriftenartikelNovel Tick Phlebovirus Genotypes Lacking Evidence for Vertebrate Infections in Anatolia and Thrace, Turkey Emanet, Nergis; Kar, Sırrı; Dinçer, Ender; Brinkmann, Annika; Hacıoğlu, Sabri; Aligholipour Farzani, Touraj; Koçak Tufan, Zeliha; Fatoş Polat, Pelin; Şahan, Adem; Özkul, Aykut; Nitsche, Andreas; Linton, Yvonne-Marie; Ergünay, KorayWe screened ticks and human clinical specimens to detect and characterize tick phleboviruses and pathogenicity in vertebrates. Ticks were collected at locations in Istanbul (Northwest Anatolia, Thrace), Edirne, Kırklareli, ...
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2019-07-26ZeitschriftenartikelProficiency Testing of Virus Diagnostics Based on Bioinformatics Analysis of Simulated In Silico High-Throughput Sequencing Data Sets Brinkmann, Annika; Andrusch, Andreas; Belka, Ariane; Wylezich, Claudia; Höper, Dirk; Pohlmann, Anne; Nordahl Petersen, Thomas; Lucas, Pierrick; Blanchard, Yannick; Papa, Anna; Melidou, Angeliki; Oude Munnink, Bas B.; Matthijnssens, Jelle; Deboutte, Ward; Ellis, Richard J.; Hansmann, Florian; Baumgärtner, Wolfgang; van der Vries, Erhard; Osterhaus, Albert; Camma, Cesare; Mangone, Iolanda; Lorusso, Alessio; Marcacci, Maurilia; Nunes, Alexandra; Pinto, Miguel; Borges, Vítor; Kroneman, Annelies; Schmitz, Dennis; Corman, Victor Max; Drosten, Christian; Jones, Terry C.; Hendriksen, Rene S.; Aarestrup, Frank M.; Koopmans, Marion; Beer, Martin; Nitsche, AndreasQuality management and independent assessment of high-throughput sequencing-based virus diagnostics have not yet been established as a mandatory approach for ensuring comparable results. The sensitivity and specificity of ...
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2014-12-15ZeitschriftenartikelProtocol for Metagenomic Virus Detection in Clinical Specimens Kohl, Claudia; Brinkmann, Annika; Dabrowski, Piotr Wojtek; Radonić, Aleksandar; Nitsche, Andreas; Kurth, AndreasSixty percent of emerging viruses have a zoonotic origin, making transmission from animals a major threat to public health. Prompt identification and analysis of these pathogens are indispensable to taking action toward ...
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2020-12-04ZeitschriftenartikelRe-assembly of nineteenth-century smallpox vaccine genomes reveals the contemporaneous use of horsepox and horsepox-related viruses in the USA Brinkmann, Annika; Souza, Aline R. V.; Esparza, José; Nitsche, Andreas; Damaso, Clarissa R.According to a recent article published in Genome Biology, Duggan and coworkers sequenced and partially assembled five genomes of smallpox vaccines from the nineteenth century. No information regarding the ends of genomes ...
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2021-06-02ZeitschriftenartikelResource-efficient internally controlled in-house real-time PCR detection of SARS-CoV-2 Michel, Janine; Neumann, Markus; Krause, Eva; Rinner, Thomas; Muzeniek, Therese; Grossegesse, Marica; Hille, Georg; Schwarz, Franziska; Puyskens, Andreas; Förster, Sophie; Biere, Barbara; Bourquain, Daniel; Domingo, Cristina; Brinkmann, Annika; Schaade, Lars; Schrick, Livia; Nitsche, AndreasBackground The reliable detection of SARS-CoV-2 has become one of the most important contributions to COVID-19 crisis management. With the publication of the first sequences of SARS-CoV-2, several diagnostic PCR assays ...