Browsing by Author "Doellinger, Joerg"

Now showing items 1-6 of 6

2018-01-29Zeitschriftenartikel

Global ubiquitination analysis reveals extensive modification and proteasomal degradation of cowpox virus proteins, but preservation of viral cores

Grossegesse, Marica; Doellinger, Joerg; Fritsch, Annemarie; Laue, Michael; Piesker, Janett; Schaade, Lars; Nitsche, Andreas

The emergence of Variola virus-like viruses by natural evolution of zoonotic Orthopoxviruses, like Cowpox virus (CPXV), is a global health threat. The proteasome is essential for poxvirus replication, making the viral ...
2022-08-03Zeitschriftenartikel

Perchlorate-specific proteomic stress responses of Debaryomyces hansenii could enable microbial survival in Martian brines

Heinz, Jacob; Doellinger, Joerg; Maus, Deborah; Schneider, Andy; Lasch, Peter; Grossart, Hans-Peter; Schulze-Makuch, Dirk

If life exists on Mars, it would face several challenges including the presence of perchlorates, which destabilize biomacromolecules by inducing chaotropic stress. However, little is known about perchlorate toxicity for ...
2020-10-22Zeitschriftenartikel

Perspective on Proteomics for Virus Detection in Clinical Samples

Grossegesse, Marica; Hartkopf, Felix; Nitsche, Andreas; Schaade, Lars; Doellinger, Joerg; Muth, Thilo

One of the most widely used methods to detect an acute viral infection in clinical specimens is diagnostic real-time polymerase chain reaction. However, because of the COVID-19 pandemic, mass-spectrometry-based proteomics ...
2023-06-14Zeitschriftenartikel

Phenotypic and genotypic discrimination of Francisella tularensis ssp. holarctica clades

Köppen, Kristin; Rydzewski, Kerstin; Doellinger, Joerg; Myrtennäs, Kerstin; Forsman, Mats; Appelt, Sandra; Scholz, Holger; Heuner, Klaus

Francisella tularensis is the causative agent of tularemia, a zoonotic disease with a wide host range. F. tularensis ssp. holarctica (Fth) is of clinical relevance for European countries, including Germany. Whole genome ...
2019-06-08Zeitschriftenartikel

Purple: A Computational Workflow for Strategic Selection of Peptides for Viral Diagnostics Using MS-Based Targeted Proteomics

Lechner, Johanna; Hartkopf, Felix; Hiort, Pauline; Nitsche, Andreas; Grossegesse, Marica; Doellinger, Joerg; Renard, Bernhard Y.; Muth, Thilo

Emerging virus diseases present a global threat to public health. To detect viral pathogens in time-critical scenarios, accurate and fast diagnostic assays are required. Such assays can now be established using mass ...
2020-09-08Zeitschriftenartikel

Silence as a way of niche adaptation: mecC-MRSA with variations in the accessory gene regulator (agr) functionality express kaleidoscopic phenotypes

Huber, Charlotte; Stamm, Ivonne; Ziebuhr, Wilma; Marincola, Gabriella; Bischoff, Markus; Strommenger, Birgit; Jaschkowitz, Greta; Marciniak, Tessa; Cuny, Christiane; Witte, Wolfgang; Doellinger, Joerg; Schaudinn, Christoph; Thürmer, Andrea; Epping, Lennard; Semmler, Torsten; Lübke-Becker, Antina; Wieler, Lothar H.; Walther, Birgit

Functionality of the accessory gene regulator (agr) quorum sensing system is an important factor promoting either acute or chronic infections by the notorious opportunistic human and veterinary pathogen Staphylococcus ...