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Auflistung nach Autor "Michel, Janine"
Anzeige der Publikationen 1-20 von 29
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2021-07-01ZeitschriftenartikelAmpliCoV: Rapid Whole-Genome Sequencing Using Multiplex PCR Amplification and Real-Time Oxford Nanopore MinION Sequencing Enables Rapid Variant Identification of SARS-CoV-2 Brinkmann, Annika; Ulm, Sophie-Luisa; Uddin, Steven; Förster, Sophie; Seifert, Dominique; Oehme, Rainer; Corty, Merle; Schaade, Lars; Michel, Janine; Nitsche, AndreasSince the emergence of the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) in December 2019, the scientific community has been sharing data on epidemiology, diagnostic methods, and whole-genomic sequences ...
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2021-04-20ZeitschriftenartikelAn intra-host SARS-CoV-2 dynamics model to assess testing and quarantine strategies for incoming travelers, contact management, and de-isolation van der Toorn, Wiep; Oh, Djin-Ye; Bourquain, Daniel; Michel, Janine; Krause, Eva; Nitsche, Andreas; von Kleist, MaxNon-pharmaceutical interventions (NPIs) remain decisive tools to contain SARS-CoV-2. Strategies that combine NPIs with testing may improve efficacy and shorten quarantine durations. We developed a stochastic within-host ...
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2021-06-08ZeitschriftenartikelDelayed Antibody and T-Cell Response to BNT162b2 Vaccination in the Elderly, Germany Schwarz, Tatjana; Tober-Lau, Pinkus; Hillus, David; Helbig, Elisa T.; Lippert, Lena J.; Thibeault, Charlotte; Koch, Willi; Landgraf, Irmgard; Michel, Janine; Bergfeld, Leon; Niemeyer, Daniela; Mühlemann, Barbara; Conrad, Claudia; Dang-Heine, Chantip; Kasper, Stefanie; Münn, Friederike; Kappert, Kai; Nitsche, Andreas; Tauber, Rudolf; Schmidt, Sein; Kopankiewicz, Piotr; Bias, Harald; Seybold, Joachim; von Kalle, Christof; Jones, Terry C.; Suttorp, Norbert; Drosten, Christian; Sander, Leif Erik; Corman, Victor M.; Kurth, FlorianWe detected delayed and reduced antibody and T-cell responses after BNT162b2 vaccination in 71 elderly persons (median age 81 years) compared with 123 healthcare workers (median age 34 years) in Germany. These data emphasize ...
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2017-05-30ZeitschriftenartikelDifferent features of Vδ2 T and NK cells in fatal and non-fatal human Ebola infections Cimini, Eleonora; Viola, Domenico; Cabeza-Cabrerizo, Mar; Romanelli, Antonella; Tumino, Nicola; Sacchi, Alessandra; Bordoni, Veronica; Casetti, Rita; Turchi, Federica; Martini, Federico; Bore, Joseph A.; Koundouno, Fara Raymond; Duraffour, Sophie; Michel, Janine; Holm, Tobias; Zekeng, Elsa Gayle; Cowley, Lauren; Dorival, Isabel Garcia; Doerrbecker, Juliane; Hetzelt, Nicole; Baum, Jonathan H. J.; Portmann, Jasmine; Muñoz-Fontela, César; Agrati, ChiaraBackground: Human Ebola infection is characterized by a paralysis of the immune system. A signature of αβ T cells in fatal Ebola infection has been recently proposed, while the involvement of innate immune cells in the ...
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2023-06-01ZeitschriftenartikelDirect comparison of clinical diagnostic sensitivity of saliva from buccal swabs versus combined oro-/nasopharyngeal swabs in the detection of SARS-CoV-2 B.1.1.529 Omicron Puyskens, Andreas; Michel, Janine; Stoliaroff-Pepin, Anna; Bayram, Fatimanur; Sesver, Akin; Wichmann, Ole; Harder, Thomas; Schaade, Lars; Nitsche, Andreas; Peine, CarolineBackground/Purpose: While current guidelines recommend the use of respiratory tract specimens for the direct detection of SARS-CoV-2 infection, saliva has recently been suggested as preferred sample type for the ...
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2021-06-18ZeitschriftenartikelFirst Serological Evidence of Crimean-Congo Hemorrhagic Fever Virus and Rift Valley Fever Virus in Ruminants in Tunisia Zouaghi, Khaoula; Bouattour, Ali; Aounallah, Hajer; Surtees, Rebecca; Krause, Eva; Michel, Janine; Mamlouk, Aymen; Nitsche, Andreas; M’ghirbi, YoumnaCrimean-Congo hemorrhagic fever virus (CCHFV, Nairoviridae family) and Rift Valley fever virus (RVFV, Phenuiviridae family) are zoonotic vector-borne pathogens with clinical relevance worldwide. Our study aimed to determine ...
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2024-04-19Berichte und sonstige TexteGrippeWeb-Wochenbericht KW 15 Kalenderwoche 15 (8.4. – 14.4.2024), Datenstand: 16.4.2024Buchholz, Udo; Buda, Silke; Eberle, Caroline; Hoffmeister, Melanie; Lehfeld, Ann-Sophie; Loenenbach, Anna; Michel, Janine; Prahm, Kerstin; Preuß, Ute; Haas, Walter; AMELAG-TeamDie Aktivität akuter Atemwegserkrankungen (ARE-Inzidenz) in der Bevölkerung ist in der 15. KW 2024 im Vergleich zur Vorwoche insgesamt relativ stabil geblieben und lag bei rund 4.700 ARE pro 100.000 Einw. (Vorwoche: 4.600). ...
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2023-10-27Berichte und sonstige TexteGrippeWeb-Wochenbericht KW 42 Kalenderwoche 42 (16.10. – 22.10.2023), Datenstand: 24.10.2023Buchholz, Udo; Buda, Silke; Hoffmeister, Melanie; Kus, Angelina; Lehfeld, Ann-Sophie; Loenenbach, Anna; Michel, Janine; Prahm, Kerstin; Preuß, Ute; Streib, Viktoria; Haas, WalterDie Aktivität akuter Atemwegserkrankungen (ARE-Inzidenz) in der Bevölkerung ist in der 42. KW 2023 im Vergleich zur Vorwoche gestiegen und lag bei 8.000 ARE pro 100.000 Einwohner (Einw.) (Vorwoche: 7.000). Dabei sind die ...
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2023-11-10Berichte und sonstige TexteGrippeWeb-Wochenbericht KW 44 Kalenderwoche 44 (30.10. – 5.11.2023), Datenstand: 7.11.2023Buchholz, Udo; Buda, Silke; Hoffmeister, Melanie; Kus, Angelina; Lehfeld, Ann-Sophie; Loenenbach, Anna; Michel, Janine; Prahm, Kerstin; Preuß, Ute; Streib, Viktoria; Haas, WalterDie Aktivität akuter Atemwegserkrankungen (ARE-Inzidenz) in der Bevölkerung ist in der 44. KW 2023 im Vergleich zur Vorwoche insgesamt gesunken und lag bei 7.500 ARE pro 100.000 Einwohner (Einw.) (Vorwoche: 8.600). Dabei ...
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2019-02-21ZeitschriftenartikelLaboratory Findings, Compassionate Use of Favipiravir, and Outcome in Patients With Ebola Virus Disease, Guinea, 2015—A Retrospective Observational Study Kerber, Romy; Lorenz, Eva; Duraffour, Sophie; Sissoko, Daouda; Rudolf, Martin; Jaeger, Anna; Ditinn Cisse, Sekou; Camara, Alseny-Modet; Miranda, Osvaldo; Castro, Carlos M.; Akoi Bore, Joseph; Kundouno, Fara Raymond; Repits, Johanna; Afrough, Babak; Becker-Ziaja, Beate; Hinzmann, Julia; Mertens, Marc; Vitoriano, Ines; Logue, Christopher Hugh; Böttcher, Jan-Peter; Pallasch, Elisa; Sachse, Andreas; Bah, Amadou; Cabeza-Cabrerizo, Mar; Nitzsche, Katja; Kuisma, Eeva; Michel, Janine; Holm, Tobias; Zekeng, Elsa Gayle; Cowley, Lauren A.; Garcia-Dorival, Isabel; Hetzelt, Nicole; Baum, Jonathan Hans Josef; Portmann, Jasmine; Carter, Lisa; Yenamaberhan, Rahel Lemma; Camino, Alvaro; Enkirch, Theresa; Singethan, Katrin; Meisel, Sarah; Mazzarelli, Antonio; Kosgei, Abigail; Kafetzopoulou, Liana; Rickett, Natasha Y.; Patrono, Livia Victoria; Ghebreghiorghis, Luam; Arnold, Ulrike; Colin, Géraldine; Juchet, Sylvain; Marchal, Claire Levy; Kolie, Jacques Seraphin; Beavogui, Abdoul Habib; Wurr, Stephanie; Bockholt, Sabrina; Krumkamp, Ralf; May, Jürgen; Stoecker, Kilian; Fleischmann, Erna; Ippolito, Giuseppe; Carroll, Miles W.; Koivogui, Lamine; Magassouba, N’Faly; Keita, Sakoba; Gurry, Céline; Drury, Patrick; Diallo, Boubacar; Formenty, Pierre; Wölfel, Roman; Di Caro, Antonino; Gabriel, Martin; Anglaret, Xavier; Malvy, Denis; Günther, StephanBackground In 2015, the laboratory at the Ebola treatment center in Coyah, Guinea, confirmed Ebola virus disease (EVD) in 286 patients. The cycle threshold (Ct) of an Ebola virus–specific reverse transcription–polymerase ...
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2022-01-24ZeitschriftenartikelLongitudinal SARS-CoV-2 seroepidemiological investigation among healthcare workers at a tertiary care hospital in Germany Tomczyk, Sara; Hönning, Alexander; Hermes, Julia; Grossegesse, Marica; Hofmann, Natalie; Michel, Janine; Neumann, Markus; Nitsche, Andreas; Hoppe, Berthold; Eckmanns, Tim; Schmidt‑Traub, Hajo; Zappel, KristinaBackground: SARS-CoV-2 cases in Germany increased in early March 2020. By April 2020, cases among health care workers (HCW) were detected across departments at a tertiary care hospital in Berlin, prompting a longitudinal ...
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2021-02-10ZeitschriftenartikelMorphometry of SARS-CoV and SARS-CoV-2 particles in ultrathin plastic sections of infected Vero cell cultures Laue, Michael; Kauter, Anne; Hoffmann, Tobias; Möller, Lars; Michel, Janine; Nitsche, AndreasSARS-CoV-2 is the causative of the COVID-19 disease, which has spread pandemically around the globe within a few months. It is therefore necessary to collect fundamental information about the disease, its epidemiology and ...
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2016-12-10ZeitschriftenartikelPersistence and clearance of Ebola virus RNA from seminal fluid of Ebola virus disease survivors: a longitudinal analysis and modelling study Sissoko, Daouda; Duraffour, Sophie; Kerber, Romy; Kolie, Jacques Seraphin; Habib Beavogui, Abdoul; Camara, Alseny Modet; Colin Pharm, Géraldine; Rieger, Toni; Oestereich, Lisa; Pályi, Bernadett; Wurr, Stephanie; Guedj, Jeremie; Tram Nguyen, Thi Huyen; Eggo, Rosalind M.; Watson, Conall H.; Edmunds, John; Akoi Bore, Joseph; Raymond Koundouno, Fara; Cabeza-Cabrerizo, Mar; Carter, Lisa L.; Kafetzopoulou, Liana Eleni; Kuisma, Eeva; Michel, Janine; Patrono, Livia V.; Rickett, Natasha Y.; Singethan, Katrin; Rudolf, Martin; Lander, Angelika; Pallasch, Elisa; Bockholt, Sabrina; Rodríguez, Estefanía; Di Caro, Antonino; Wölfel, Roman; Gabriel, Martin; Gurry, Céline; Formenty, Pierre; Keïta, Sakoba; Malvy, Denis; Carroll, Miles; Anglaret, Xavier; Günther, StephanBackground By January, 2016, all known transmission chains of the Ebola virus disease (EVD) outbreak in west Africa had been stopped. However, there is concern about persistence of Ebola virus in the reproductive tract ...
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2021-06-24ZeitschriftenartikelPositivenanteile, RNA-Kopien und Anzüchtbarkeit von Proben zum Isolationsende von SARS-CoV-2 VOC B.1.1.7 („Alpha“) positiven Fallpersonen; LK Bergstraße; März 2021 Loenenbach, Anna; Markus, Inessa; Stauke, Janina; Michel, Janine; Nitsche, Andreas; Unger-Goldinger, Barbara; Weidenauer, Cornelius; Schlosser, Helen; Beile, Alexander; Buchholz, UdoDie Virusvariante B.1.1.7 („Alpha“), die seit Dezember 2020 in Deutschland zirkuliert und seit etwa Ende Februar 2021 das In¬fektionsgeschehen dominiert, gilt als transmissibler als die bis dato zirkulierenden Va¬rianten. ...
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2021-06-02ZeitschriftenartikelResource-efficient internally controlled in-house real-time PCR detection of SARS-CoV-2 Michel, Janine; Neumann, Markus; Krause, Eva; Rinner, Thomas; Muzeniek, Therese; Grossegesse, Marica; Hille, Georg; Schwarz, Franziska; Puyskens, Andreas; Förster, Sophie; Biere, Barbara; Bourquain, Daniel; Domingo, Cristina; Brinkmann, Annika; Schaade, Lars; Schrick, Livia; Nitsche, AndreasBackground The reliable detection of SARS-CoV-2 has become one of the most important contributions to COVID-19 crisis management. With the publication of the first sequences of SARS-CoV-2, several diagnostic PCR assays ...
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2022-01-20ZeitschriftenartikelRNA reference materials with defined viral RNA loads of SARS-CoV-2—A useful tool towards a better PCR assay harmonization Vierbaum, Laura; Wojtalewicz, Nathalie; Grunert, Hans-Peter; Lindig, Vanessa; Duehring, Ulf; Drosten, Christian; Corman, Victor; Niemeyer, Daniela; Ciesek, Sandra; Rabenau, Holger F.; Berger, Annemarie; Obermeier, Martin; Nitsche, Andreas; Michel, Janine; Mielke, Martin; Huggett, Jim; O’Sullivan, Denise; Busby, Eloise; Cowen, Simon; Vallone, Peter M.; Cleveland, Megan H.; Falak, Samreen; Kummrow, Andreas; Keller, Thomas; Schellenberg, Ingo; Zeichhardt, Heinz; Kammel, MartinSARS-CoV-2, the cause of COVID-19, requires reliable diagnostic methods to track the circulation of this virus. Following the development of RT-qPCR methods to meet this diagnostic need in January 2020, it became clear ...
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2021-12-13ZeitschriftenartikelSARS-CoV-2 Transmissibility Within Day Care Centers—Study Protocol of a Prospective Analysis of Outbreaks in Germany Schienkiewitz, Anja; Jordan, Susanne; Hornbacher, Anselm; Perlitz, Hanna; Zeisler, Marie-Luise; Sandoni, Anna; Kubisch, Ulrike; Wess, Barbara; Kuttig, Tim; Schaffrath-Rosario, Angelika; Damerow, Stefan; Rattay, Petra; Varnaccia, Gianni; Loer, Anne-Kathrin M.; Wormsbächer, Jan; Cohrdes, Carolin; Wetzstein, Matthias; Albrecht, Stefan; Hey, Isabell; Michel, Janine; Schrick, Livia; Gößwald, Antje; Allen, Jennifer; Schlaud, Martin; Busch, Markus A.; Butschalowsky, Hans; Wernitz, Jörg; im Kampe, Eveline Otte; Buchholz, Udo; Haas, Walter; Schaade, Lars; Wieler, Lothar H.; Ziese, Thomas; Lampert, Thomas; Loss, JulikaIntroduction: Until today, the role of children in the transmission dynamics of SARS-CoV-2 and the development of the COVID-19 pandemic seems to be dynamic and is not finally resolved. The primary aim of this study is to ...
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2021-05-08ZeitschriftenartikelSensitive on-site detection of SARS-CoV-2 by ID NOW COVID-19 Krause, Eva; Puyskens, Andrea; Bourquain, Daniel; Brinkmann, Annika; Biere, Barbara; Schaade, Lars; Michel, Janine; Nitsche, AndreasPoint of care detection of SARS-CoV-2 is one pillar in a containment strategy and important to break infection chains. Here we report the sensitive, specific and robust detection of SARS-CoV-2 and respective variants of ...
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2021-03-25ZeitschriftenartikelSeroepidemiological study on the spread of SARS-CoV-2 in Germany: Study protocol of the ‘CORONA-MONITORING bundesweit’ study (RKI-SOEP study)Hoebel, Jens; Busch, Markus A.; Grabka, Markus M.; Zinn, Sabine; Allen, Jennifer; Gößwald, Antje; Wernitz, Jörg; Goebel, Jan; Steinhauer, Hans Walter; Siegers, Rainer; Schröder, Carsten; Kuttig, Tim; Butschalowsky, Hans; Schlaud, Martin; Schaffrath Rosario, Angelika; Brix, Jana; Rysina, Anna; Glemser, Axel; Neuhauser, Hannelore; Stahlberg, Silke; Kneuer, Antje; Hey, Isabell; Schaarschmidt, Jörg; Fiebig, Julia; Buttmann-Schweiger, Nina; Wilking, Hendrik; Michel, Janine; Nitsche, Andreas; Wieler, Lothar H.; Schaade, Lars; Ziese, Thomas; Liebig, Stefan; Lampert, ThomasThe SARS-CoV-2 coronavirus has spread rapidly across Germany. Infections are likely to be under-recorded in the notification data from local health authorities on laboratory-confirmed cases since SARS-CoV-2 infections can ...
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2021-02-10Berichte und sonstige TexteSeroepidemiologische Studie zur bundesweiten Verbreitung von SARS-CoV-2 in Deutschland: Studienprotokoll von CORONA-MONITORING bundesweit (RKI-SOEP-Studie) Hoebel, Jens; Busch, Markus A.; Grabka, Markus M.; Zinn, Sabine; Allen, Jennifer; Gößwald, Antje; Wernitz, Jörg; Goebel, Jan; Steinhauer, Hans Walter; Siegers, Rainer; Schröder, Carsten; Kuttig, Tim; Butschalowsky, Hans; Schlaud, Martin; Schaffrath Rosario, Angelika; Brix, Jana; Rysina, Anna; Glemser, Axel; Neuhauser, Hannelore; Stahlberg, Silke; Kneuer, Antje; Hey, Isabell; Schaarschmidt, Jörg; Fiebig, Julia; Buttmann-Schweiger, Nina; Wilking, Hendrik; Michel, Janine; Nitsche, Andreas; Wieler, Lothar H.; Schaade, Lars; Ziese, Thomas; Liebig, Stefan; Lampert, ThomasDas Coronavirus SARS-CoV-2 hat sich in kurzer Zeit bundesweit ausgebreitet. In den Meldedaten der Gesundheitsämter zu laborbestätigten Infektionsfällen ist von einer Untererfassung des Infektionsgeschehens auszugehen, da ...