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Browsing by Author "Bourquain, Daniel"
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2021-04-20ZeitschriftenartikelAn intra-host SARS-CoV-2 dynamics model to assess testing and quarantine strategies for incoming travelers, contact management, and de-isolation van der Toorn, Wiep; Oh, Djin-Ye; Bourquain, Daniel; Michel, Janine; Krause, Eva; Nitsche, Andreas; von Kleist, MaxNon-pharmaceutical interventions (NPIs) remain decisive tools to contain SARS-CoV-2. Strategies that combine NPIs with testing may improve efficacy and shorten quarantine durations. We developed a stochastic within-host ...
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2013-02-20ZeitschriftenartikelComparison of host cell gene expression in cowpox, monkeypox or vaccinia virus-infected cells reveals virus-specific regulation of immune response genes Bourquain, Daniel; Dabrowski, Piotr Wojtek; Nitsche, AndreasBackground: Animal-borne orthopoxviruses, like monkeypox, vaccinia and the closely related cowpox virus, are all capable of causing zoonotic infections in humans, representing a potential threat to human health. The ...
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2011-08-01ZeitschriftenartikelProteome analysis of vaccinia virus IHD-W-infected HEK 293 cells with 2-dimensional gel electrophoresis and MALDI-PSD-TOF MS of on solid phase support N-terminally sulfonated peptides Bartel, Sebastian; Döllinger, Jörg; Darsow, Kai; Bourquain, Daniel; Buchholz, Rainer; Nitsche, Andreas; Lange, Harald A.Background: Despite the successful eradication of smallpox by the WHO-led vaccination programme, pox virus infections remain a considerable health threat. The possible use of smallpox as a bioterrorism agent as well as ...
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2019-09-14ZeitschriftenartikelPuumala and Tula Virus Differ in Replication Kinetics and Innate Immune Stimulation in Human Endothelial Cells and Macrophages Bourquain, Daniel; Bodenstein, Clemens; Schürer, Stefanie; Schaade, LarsOld world hantaviruses cause hemorrhagic fever with renal syndrome (HFRS) upon zoonotic transmission to humans. In Europe, the Puumala virus (PUUV) is the main causative agent of HFRS. Tula virus (TULV) is also widely ...
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2021-08-23ZeitschriftenartikelReplication of cowpox virus in macrophages is dependent on the host range factor p28/N1R Bourquain, Daniel; Schrick, Livia; Tischer, Bernd Karsten; Osterrieder, Klaus; Schaade, Lars; Nitsche, AndreasZoonotic orthopoxvirus infections continue to represent a threat to human health. The disease caused by distinct orthopoxviruses differs in terms of symptoms and severity, which may be explained by the unique repertoire ...
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2021-06-02ZeitschriftenartikelResource-efficient internally controlled in-house real-time PCR detection of SARS-CoV-2 Michel, Janine; Neumann, Markus; Krause, Eva; Rinner, Thomas; Muzeniek, Therese; Grossegesse, Marica; Hille, Georg; Schwarz, Franziska; Puyskens, Andreas; Förster, Sophie; Biere, Barbara; Bourquain, Daniel; Domingo, Cristina; Brinkmann, Annika; Schaade, Lars; Schrick, Livia; Nitsche, AndreasBackground The reliable detection of SARS-CoV-2 has become one of the most important contributions to COVID-19 crisis management. With the publication of the first sequences of SARS-CoV-2, several diagnostic PCR assays ...
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2021-05-08ZeitschriftenartikelSensitive on-site detection of SARS-CoV-2 by ID NOW COVID-19 Krause, Eva; Puyskens, Andrea; Bourquain, Daniel; Brinkmann, Annika; Biere, Barbara; Schaade, Lars; Michel, Janine; Nitsche, AndreasPoint of care detection of SARS-CoV-2 is one pillar in a containment strategy and important to break infection chains. Here we report the sensitive, specific and robust detection of SARS-CoV-2 and respective variants of ...