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Auflistung nach Autor "Drosten, Christian"
Anzeige der Publikationen 1-20 von 24
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2011-06-14ZeitschriftenartikelAn insect nidovirus emerging from a primary tropical rainforest. Zirkel, Florian; Kurth, Andreas; Quan, Phenix-Lan; Briese, Thomas; Ellerbrok, Heinz; Pauli, Georg; Leendertz, Fabian; Lipkin, W. Ian; Ziebuhr, John; Drosten, Christian; Junglen, SandraTropical rainforests show the highest level of terrestrial biodiversity and may be an important contributor to microbial diversity. Exploitation of these ecosystems may foster the emergence of novel pathogens. We report ...
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2012-12-06ZeitschriftenartikelAssays for laboratory confirmation of novel human coronavirus (hCoV-EMC) infections Corman, V. M.; Müller, Marcel A.; Costabel, U.; Timm, J.; Binger, T.; Meyer, B.; Kreher, Petra; Lattwein, Erik; Eschbach-Bludau, M.; Nitsche, Andreas; Bleicker, T.; Landt, Olfert; Schweiger, Brunhilde; Drexler, Jan Felix; Osterhaus, A. D.; Haagmans, B. L.; Dittmer, U.; Bonin, F.; Wolff, Thorsten; Drosten, ChristianWe present a rigorously validated and highly sensitive confirmatory real-time RT-PCR assay (1A assay) that can be used in combination with the previously reported upE assay. Two additional RT-PCR assays for sequencing are ...
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2014-03-17ZeitschriftenartikelContact Investigation for Imported Case of Middle East Respiratory Syndrome, Germany Reuss, Annicka; Litterst, Annette; Drosten, Christian; Seilmaier, Michael; Böhmer, Merle; Graf, Petra; Gold, Hermann; Wendtner, Clemens-Martin; Zanuzdana, Arina; Schaade, Lars; Haas, Walter; Buchholz, UdoOn March 19, 2013, a patient from United Arab Emirates who had severe respiratory infection was transferred to a hospital in Germany, 11 days after symptom onset. Infection with Middle East respiratory syndrome coronavirus ...
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2013-02-21ZeitschriftenartikelContact investigation of a case of human novel coronavirus infection treated in a German hospital, October-November 2012 Buchholz, Udo; Müller, Marcel A.; Nitsche, Andreas; Sanewski, A.; Wevering, N.; Bauer-Balci, T.; Bonin, F.; Drosten, Christian; Schweiger, Brunhilde; Wolff, Thorsten; Muth, D.; Meyer, B.; Buda, Silke; Krause, Gérard; Schaade, Lars; Haas, WalterOn 24 October 2012, a patient with acute respiratory distress syndrome of unknown origin and symptom onset on 5 October was transferred from Qatar to a specialist lung clinic in Germany. Late diagnosis on 20 November of ...
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2009-03-01ZeitschriftenartikelCoordinated Implementation of Chikungunya Virus Reverse Transcription–PCR. Panning, Marcus; Charrel, Remi N.; Mantke, Oliver Donoso; Landt, Olfert; Niedrig, Matthias; Drosten, ChristianA preformulated chikungunya virus real-time reverse transcription-PCR, quality-confirmed oligonucleotides, and noninfectious virus controls were distributed by the European Network for the Diagnosis of Imported Viral ...
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2007-09-01ZeitschriftenartikelCoronavirus Antibodies in African Bat Species Müller, Marcel A.; Paweska, Janusz T.; Leman, Patricia A.; Drosten, Christian; Grywna, Klaus; Kemp, Alan; Braack, Leo; Sonnenberg, Karen; Niedrig, Matthias; Swanepoel, RobertAsian bats have been identified as potential reservoir hosts of coronaviruses associated with severe acute respiratory syndrome (SARS-CoV). We detected antibody reactive with SARS-CoV antigen in 47 (6.7%) of 705 bat serum ...
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2021-06-08ZeitschriftenartikelDelayed Antibody and T-Cell Response to BNT162b2 Vaccination in the Elderly, Germany Schwarz, Tatjana; Tober-Lau, Pinkus; Hillus, David; Helbig, Elisa T.; Lippert, Lena J.; Thibeault, Charlotte; Koch, Willi; Landgraf, Irmgard; Michel, Janine; Bergfeld, Leon; Niemeyer, Daniela; Mühlemann, Barbara; Conrad, Claudia; Dang-Heine, Chantip; Kasper, Stefanie; Münn, Friederike; Kappert, Kai; Nitsche, Andreas; Tauber, Rudolf; Schmidt, Sein; Kopankiewicz, Piotr; Bias, Harald; Seybold, Joachim; von Kalle, Christof; Jones, Terry C.; Suttorp, Norbert; Drosten, Christian; Sander, Leif Erik; Corman, Victor M.; Kurth, FlorianWe detected delayed and reduced antibody and T-cell responses after BNT162b2 vaccination in 71 elderly persons (median age 81 years) compared with 123 healthcare workers (median age 34 years) in Germany. These data emphasize ...
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2018-05-17ZeitschriftenartikelExternal Quality Assessment for Zika Virus Molecular Diagnostic Testing, Brazil Fischer, Carlo; Pedroso, Celia; Mendrone, Alfredo; Filippis, Ana Maria Bispo de; Vallinoto, Antonio Carlos Rosário; Ribeiro, Bergmann Morais; Durigon, Edison Luiz; Marques, Ernesto T.A.; Campos, Gubio S.; Viana, Isabelle F.T.; Levi, José Eduardo; Scarpelli, Luciano Cesar; Nogueira, Mauricio Lacerda; Bastos, Michele de Souza; Souza, Nathalia C. Santiago; Khouri, Ricardo; Lira, Sanny M. Costa; Komninakis, Shirley Vasconcelos; Baronti, Cécile; Charrel, Rémi N.; Kümmerer, Beate M.; Drosten, Christian; Niedrig, Matthias; Netto, Eduardo Martins; Drexler, Jan FelixWe conducted an external quality assessment of Zika virus molecular diagnostic tests in Brazil using a new Zika virus standard. Of 15 laboratories, 73% showed limited sensitivity and specificity. Viral load estimates varied ...
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2015-05-30ZeitschriftenartikelFirst international external quality assessment of molecular diagnostics for Mers-CoV Pas, Suzan D.; Patel, Pranav; Reusken, Chantal; Domingo, Cristina; Corman, Victor M.; Drosten, Christian; Dijkman, Ronald; Thiel, Volker; Nowotny, Norbert; Koopmans, Marion P.G.; Niedrig, MatthiasBackground: Since the discovery of Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012, diagnostic protocols were quickly published and deployed globally. Objectives: We set out to assess the quality of ...
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2012-01-01ZeitschriftenartikelHantavirus in Bat, Sierra Leone Weiss, Sabrina; Witkowski, Peter T.; Auste, Brita; Nowak, Kathrin; Weber, Natalie; Fahr, Jakob; Mombouli, Jean-Vivien; Wolfe, Nathan D.; Drexler, Jan Felix; Drosten, Christian; Klempa, Boris; Leendertz, Fabian; Krüger, Detlev H.
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2010-01-15ZeitschriftenartikelHuman Coronavirus NL63 Open Reading Frame 3 encodes a virion-incorporated N-glycosylated membrane protein Müller, Marcel A.; Hoek, Lia van der; Voss, Daniel; Bader, Oliver; Lehmann, Dörte; Schulz, Axel R.; Kallies, Stephan; Suliman, Tasnim; Fielding, Burtram C; Drosten, Christian; Niedrig, MatthiasBackground: Human pathogenic coronavirus NL63 (hCoV-NL63) is a group 1 (alpha) coronavirus commonly associated with respiratory tract infections. In addition to known non-structural and structural proteins all coronaviruses ...
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2018-06-27ZeitschriftenartikelHuman coronavirus OC43 outbreak in wild chimpanzees, Côte d´Ivoire, 2016 Patrono, Livia V.; Samuni, Liran; Corman, Victor M.; Nourifar, Leila; Röthemeier, Caroline; Wittig, Roman M.; Drosten, Christian; Calvignac-Spencer, Sébastien; Leendertz, Fabian H.
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2021-05-17ZeitschriftenartikelKommunikationsempfehlungen zur Verbesserung des Verhaltens bei der Verwendung von PoC Antigen-Schnelltests und Selbsttests Jenny, Mirjam A.; Lein, Ines; Jung-Sendzik, Tanja; Eitze, Sarah; Drosten, Christian; Betsch, CorneliaDie breitere Anwendung von Antigentests zum Auffinden einer akuten Infektion mit SARS-CoV-2 beinhaltet Chancen, aber auch Risiken und Limitationen. Die Tests können als einer von mehreren Bausteinen zur Pandemiekontrolle ...
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2023-04-02ZeitschriftenartikelMonitoring the SARS-CoV-2 Pandemic: Prevalence of Antibodies in a Large, Repetitive Cross-Sectional Study of Blood Donors in Germany—Results from the SeBluCo Study 2020–2022 Offergeld, Ruth; Preußel, Karina; Zeiler, Thomas; Aurich, Konstanze; Baumann-Baretti, Barbara I.; Ciesek, Sandra; Corman, Victor M.; Dienst, Viktoria; Drosten, Christian; Görg, Siegfried; Greinacher, Andreas; Grossegesse, Marica; Haller, Sebastian; Heuft, Hans-Gert; Hofmann, Natalie; Horn, Peter A.; Houareau, Claudia; Gülec, Ilay; Jiménez Klingberg, Carlos Luis; Juhl, David; Lindemann, Monika; Martin, Silke; Neuhauser, Hannelore K.; Nitsche, Andreas; Ohme, Julia; Peine, Sven; Sachs, Ulrich J.; Schaade, Lars; Schäfer, Richard; Scheiblauer, Heinrich; Schlaud, Martin; Schmidt, Michael; Umhau, Markus; Vollmer, Tanja; Wagner, Franz F.; Wieler, Lothar H.; Wilking, Hendrik; Ziemann, Malte; Zimmermann, Marlow; an der Heiden, MatthiasSARS-CoV-2 serosurveillance is important to adapt infection control measures and estimate the degree of underreporting. Blood donor samples can be used as a proxy for the healthy adult population. In a repeated cross-sectional ...
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2015-12-01ZeitschriftenartikelNo Evidence of Gouléako and Herbert Virus Infections in Pigs, Côte d’Ivoire and Ghana Junglen, Sandra; Marklewitz, Marco; Zirkel, Florian; Wollny, Robert; Meyer, Benjamin; Heidemann, Hanna; Metzger, Sonja; Annan, Augustina; Dei, Dickson; Leendertz, Fabian H.; Oppong, Samuel; Drosten, ChristianA recent report suggested that 2 novel bunyaviruses discovered in insects in Côte d’Ivoire caused lethal disease in swine in South Korea. We conducted cell culture studies and tested serum from pigs exposed to mosquitoes ...
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2020-11-30ZeitschriftenartikelOlfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19 Meinhardt, Jenny; Radke, Josefine; Dittmayer, Carsten; Franz, Jonas; Thomas, Carolina; Mothes, Ronja; Laue, Michael; Schneider, Julia; Brünink, Sebastian; Greuel, Selina; Lehmann, Malte; Hassan, Olga; Aschman, Tom; Schumann, Elisa; Chua, Robert Lorenz; Conrad, Christian; Eils, Roland; Stenzel, Werner; Windgassen, Marc; Rößler, Larissa; Goebel, Hans-Hilmar; Gelderblom, Hans R.; Martin, Hubert; Nitsche, Andreas; Schulz-Schaeffer, Walter J.; Hakroush, Samy; Winkler, Martin S.; Tampe, Björn; Scheibe, Franziska; Körtvélyessy, Péter; Reinhold, Dirk; SIegmund, Britta; Kühl, Anja A.; Elezkurtaj, Sefer; Horst, David; Oesterhelweg, Lars; Tsokos, Michael; Ingold-Heppner, Barbara; Stadelmann, Christine; Drosten, Christian; Radbruch, Helena; Heppner, Frank L.; Corman, Victor MaxThe newly identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19, a pandemic respiratory disease. Moreover, thromboembolic events throughout the body, including in the CNS, have been ...
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2019-07-26ZeitschriftenartikelProficiency Testing of Virus Diagnostics Based on Bioinformatics Analysis of Simulated In Silico High-Throughput Sequencing Data Sets Brinkmann, Annika; Andrusch, Andreas; Belka, Ariane; Wylezich, Claudia; Höper, Dirk; Pohlmann, Anne; Nordahl Petersen, Thomas; Lucas, Pierrick; Blanchard, Yannick; Papa, Anna; Melidou, Angeliki; Oude Munnink, Bas B.; Matthijnssens, Jelle; Deboutte, Ward; Ellis, Richard J.; Hansmann, Florian; Baumgärtner, Wolfgang; van der Vries, Erhard; Osterhaus, Albert; Camma, Cesare; Mangone, Iolanda; Lorusso, Alessio; Marcacci, Maurilia; Nunes, Alexandra; Pinto, Miguel; Borges, Vítor; Kroneman, Annelies; Schmitz, Dennis; Corman, Victor Max; Drosten, Christian; Jones, Terry C.; Hendriksen, Rene S.; Aarestrup, Frank M.; Koopmans, Marion; Beer, Martin; Nitsche, AndreasQuality management and independent assessment of high-throughput sequencing-based virus diagnostics have not yet been established as a mandatory approach for ensuring comparable results. The sensitivity and specificity of ...
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2013-06-11ZeitschriftenartikelProvenance and Geographic Spread of St. Louis Encephalitis Virus Kopp, Anne; Gillespie, Thomas R.; Hobelsberger, Daniel; Estrada, Alejandro; Harper, James M.; Miller, Richard A.; Eckerle, Isabella; Müller, Marcel A.; Podsiadlowski, Lars; Leendertz, Fabian; Drosten, Christian; Junglen, SandraSt. Louis encephalitis virus (SLEV) is the prototypic mosquito-borne flavivirus in the Americas. Birds are its primary vertebrate hosts, but amplification in certain mammals has also been suggested. The place and time of ...
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2022-01-20ZeitschriftenartikelRNA reference materials with defined viral RNA loads of SARS-CoV-2—A useful tool towards a better PCR assay harmonization Vierbaum, Laura; Wojtalewicz, Nathalie; Grunert, Hans-Peter; Lindig, Vanessa; Duehring, Ulf; Drosten, Christian; Corman, Victor; Niemeyer, Daniela; Ciesek, Sandra; Rabenau, Holger F.; Berger, Annemarie; Obermeier, Martin; Nitsche, Andreas; Michel, Janine; Mielke, Martin; Huggett, Jim; O’Sullivan, Denise; Busby, Eloise; Cowen, Simon; Vallone, Peter M.; Cleveland, Megan H.; Falak, Samreen; Kummrow, Andreas; Keller, Thomas; Schellenberg, Ingo; Zeichhardt, Heinz; Kammel, MartinSARS-CoV-2, the cause of COVID-19, requires reliable diagnostic methods to track the circulation of this virus. Following the development of RT-qPCR methods to meet this diagnostic need in January 2020, it became clear ...
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2020-11-26ZeitschriftenartikelSerology- and PCR-based cumulative incidence of SARS-CoV-2 infection in adults in a successfully contained early hotspot (CoMoLo study), Germany, May to June 2020 Santos-Hövener, Claudia; Neuhauser, Hannelore K.; Schaffrath Rosario, Angelika; Busch, Markus; Schlaud, Martin; Hoffmann, Robert; Gößwald, Antje; Koschollek, Carmen; Hoebel, Jens; Allen, Jennifer; Haack-Erdmann, Antje; Brockmann, Stefan; Ziese, Thomas; Nitsche, Andreas; Michel, Janine; Haller, Sebastian; Wilking, Hendrik; Hamouda, Osamah; Corman, Victor M.; Drosten, Christian; Schaade, Lars; Wieler, Lothar H.; CoMoLo Study Group; Lampert, ThomasAfter a large church concert on 1 March 2020 and a first detected infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on 9 March, the southern German community of Kupferzell in the federal state ...