Browsing by Author "Weydert, Caroline"

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2015-02-12Zeitschriftenartikel

HIV-1 IN/Pol recruits LEDGF/p75 into viral particles

Desimmie, Belete Ayele; Weydert, Caroline; Schrijvers, Rik; Vets, Sofie; Demeulemeester, Jonas; Proost, Paul; Paron, Igor; Rijck, Jan de; Mast, Jan; Bannert, Norbert; Gijsbers, Rik; Christ, Frauke; Debyser, Zeger

Background: The dynamic interaction between HIV and its host governs the replication of the virus and the study of the virus-host interplay is key to understand the viral lifecycle. The host factor lens epithelium-derived ...
2013-05-30Zeitschriftenartikel

LEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions

Desimmie, Belete A.; Schrijvers, Rik; Demeulemeester, Jonas; Borrenberghs, Doortje; Weydert, Caroline; Thys, Wannes; Vets, Sofie; Remoortel, Barbara van; Hofkens, Johan; Rijck, Jan de; Hendrix, Jelle; Bannert, Norbert; Gijsbers, Rik; Christ, Frauke; Debyser, Zeger

Background: LEDGINs are novel allosteric HIV integrase (IN) inhibitors that target the lens epithelium-derived growth factor (LEDGF)/p75 binding pocket of IN. They block HIV-1 integration by abrogating the interaction ...