Browsing by Author "Mages, Hans Werner"

Now showing items 1-8 of 8

2023-12-09Zeitschriftenartikel

A bead-based multiplex assay covering all coronaviruses pathogenic for humans for sensitive and specific surveillance of SARS-CoV-2 humoral immunity

Stern, Daniel; Meyer, Tanja C.; Treindl, Fridolin; Mages, Hans Werner; Krüger, Maren; Skiba, Martin; Krüger, Jan Philipp; Zobel, Christian M.; Schreiner, Maximilian; Grossegesse, Marica; Rinner, Thomas; Peine, Caroline; Stoliaroff-Pépin, Anna; Harder, Thomas; Hofmann, Natalie; Michel, Janine; Nitsche, Andreas; Stahlberg, Silke; Kneuer, Antje; Sandoni, Anna; Kubisch, Ulrike; Schlaud, Martin; Mankertz, Annette; Schwarz, Tatjana; Corman, Victor M.; Müller, Marcel A.; Drosten, Christian; de la Rosa, Kathrin; Schaade, Lars; Dorner, Martin B.; Dorner, Brigitte G.

Serological assays measuring antibodies against SARS-CoV-2 are key to describe the epidemiology, pathobiology or induction of immunity after infection or vaccination. Of those, multiplex assays targeting multiple antigens ...
2013-10-23Zeitschriftenartikel

Cytomegalovirus expresses the chemokine homologue vXCL1 capable of attracting XCR1+CD4- dendritic cells

Geyer, Henriette; Hartung, Evelyn; Mages, Hans Werner; Weise, Christoph; Belužić, Robert; Vugrek, Oliver; Jonjić, Stipan; Kroczek, Richard; Voigt, Sebastian

Cytomegaloviruses (CMV) have developed various strategies to escape the immune system of the host. One strategy involves the expression of virus-encoded chemokines to modulate the host chemokine network. We have identified ...
2003-01-01Zeitschriftenartikel

Expression of ICOS In Vivo Defines CD4+ Effector T Cells with High Inflammatory Potential and a Strong Bias for Secretion of Interleukin 10

Löhning, Max; Hutloff, Andreas; Kallinich, Tilmann; Mages, Hans Werner; Bonhagen, Kerstin; Radbruch, Andreas; Hamelmann, Eckard; Kroczek, Richard

The studies performed to date analyzed the overall participation of the inducible costimulator (ICOS) in model diseases, but did not yield information on the nature and function of ICOS-expressing T cells in vivo. We ...
2012-07-18Zeitschriftenartikel

Expression of XCR1 characterizes the Batf3-dependent lineage of dendritic cells capable of antigen cross-presentation

Bachem, Annabell; Hartung, Evelyn; Güttler, Steffen; Mora, Ahmed; Zhou, Xuefei; Hegemann, Anika; Plantinga, Maud; Mazzini, Elisa; Stoitzner, Patrizia; Gurka, Stephanie; Henn, Volker; Mages, Hans Werner; Kroczek, Richard

Cross-presentation of antigen by dendritic cells (DCs) to CD8+ T cells is a fundamentally important mechanism in the defense against pathogens and tumors. Due to the lack of an appropriate lineage marker, cross-presenting ...
2022-04-14Zeitschriftenartikel

MALDI-TOF-MS-Based Identification of Monoclonal Murine Anti-SARS-CoV-2 Antibodies within One Hour

Tscheuschner, Georg; Kaiser, Melanie N.; Lisec, Jan; Beslic, Denis; Muth, Thilo; Krüger, Maren; Mages, Hans Werner; Dorner, Brigitte G.; Knospe, Julia; Schenk, Jörg A.; Sellrie, Frank; Weller, Michael G.

During the SARS-CoV-2 pandemic, many virus-binding monoclonal antibodies have been developed for clinical and diagnostic purposes. This underlines the importance of antibodies as universal bioanalytical reagents. However, ...
2014-07-28Zeitschriftenartikel

Ontogenic, phenotypic, and functional characterization of XCR1+ dendritic cells leads to a consistent classification of intestinal dendritic cells based on the expression of XCR1 and SIRPα

Becker, Martina; Güttler, Steffen; Bachem, Annabell; Hartung, Evelyn; Mora, Ahmed; Jäkel, Anika; Hutloff, Andreas; Henn, Volker; Mages, Hans Werner; Gurka, Stephanie; Kroczek, Richard

In the past, lack of lineage markers confounded the classification of dendritic cells (DC) in the intestine and impeded a full understanding of their location and function. We have recently shown that the chemokine receptor ...
2018-12-13Zeitschriftenartikel

Structure-Function Relationship of XCL1 Used for in vivo Targeting of Antigen Into XCR1+ Dendritic Cells

Kroczek, Arthur L.; Hartung, Evelyn; Gurka, Stephanie; Becker, Martina; Reeg, Nele; Mages, Hans Werner; Voigt, Sebastian; Freund, Christian; Kroczek, Richard

XCL1 is the ligand for XCR1, a chemokine receptor uniquely expressed on crosspresenting dendritic cells (DC) in mouse and man. We are interested in establishing therapeutic vaccines based on XCL1-mediated targeting of ...
2010-05-17Zeitschriftenartikel

Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+ cells as homologues of mouse CD8+ dendritic cells

Bachem, Annabell; Güttler, Steffen; Hartung, Evelyn; Ebstein, Frédéric; Schaefer, Michael; Tannert, Astrid; Salama, Abdulgabar; Movassaghi, Kamran; Opitz, Corinna; Mages, Hans Werner; Henn, Volker; Kloetzel, Peter-Michael; Gurka, Stephanie; Kroczek, Richard

In recent years, human dendritic cells (DCs) could be subdivided into CD304+ plasmacytoid DCs (pDCs) and conventional DCs (cDCs), the latter encompassing the CD1c+, CD16+, and CD141+ DC subsets. To date, the low frequency ...