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Browsing by Author "Mages, Hans Werner"
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2013-10-23ZeitschriftenartikelCytomegalovirus expresses the chemokine homologue vXCL1 capable of attracting XCR1+CD4- dendritic cells Geyer, Henriette; Hartung, Evelyn; Mages, Hans Werner; Weise, Christoph; Belužić, Robert; Vugrek, Oliver; Jonjić, Stipan; Kroczek, Richard; Voigt, SebastianCytomegaloviruses (CMV) have developed various strategies to escape the immune system of the host. One strategy involves the expression of virus-encoded chemokines to modulate the host chemokine network. We have identified ...
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2003-01-01ZeitschriftenartikelExpression of ICOS In Vivo Defines CD4+ Effector T Cells with High Inflammatory Potential and a Strong Bias for Secretion of Interleukin 10 Löhning, Max; Hutloff, Andreas; Kallinich, Tilmann; Mages, Hans Werner; Bonhagen, Kerstin; Radbruch, Andreas; Hamelmann, Eckard; Kroczek, RichardThe studies performed to date analyzed the overall participation of the inducible costimulator (ICOS) in model diseases, but did not yield information on the nature and function of ICOS-expressing T cells in vivo. We ...
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2012-07-18ZeitschriftenartikelExpression of XCR1 characterizes the Batf3-dependent lineage of dendritic cells capable of antigen cross-presentation Bachem, Annabell; Hartung, Evelyn; Güttler, Steffen; Mora, Ahmed; Zhou, Xuefei; Hegemann, Anika; Plantinga, Maud; Mazzini, Elisa; Stoitzner, Patrizia; Gurka, Stephanie; Henn, Volker; Mages, Hans Werner; Kroczek, RichardCross-presentation of antigen by dendritic cells (DCs) to CD8+ T cells is a fundamentally important mechanism in the defense against pathogens and tumors. Due to the lack of an appropriate lineage marker, cross-presenting ...
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2014-07-28ZeitschriftenartikelOntogenic, phenotypic, and functional characterization of XCR1+ dendritic cells leads to a consistent classification of intestinal dendritic cells based on the expression of XCR1 and SIRPα Becker, Martina; Güttler, Steffen; Bachem, Annabell; Hartung, Evelyn; Mora, Ahmed; Jäkel, Anika; Hutloff, Andreas; Henn, Volker; Mages, Hans Werner; Gurka, Stephanie; Kroczek, RichardIn the past, lack of lineage markers confounded the classification of dendritic cells (DC) in the intestine and impeded a full understanding of their location and function. We have recently shown that the chemokine receptor ...
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2018-12-13ZeitschriftenartikelStructure-Function Relationship of XCL1 Used for in vivo Targeting of Antigen Into XCR1+ Dendritic Cells Kroczek, Arthur L.; Hartung, Evelyn; Gurka, Stephanie; Becker, Martina; Reeg, Nele; Mages, Hans Werner; Voigt, Sebastian; Freund, Christian; Kroczek, RichardXCL1 is the ligand for XCR1, a chemokine receptor uniquely expressed on crosspresenting dendritic cells (DC) in mouse and man. We are interested in establishing therapeutic vaccines based on XCL1-mediated targeting of ...
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2010-05-17ZeitschriftenartikelSuperior antigen cross-presentation and XCR1 expression define human CD11c+CD141+ cells as homologues of mouse CD8+ dendritic cells Bachem, Annabell; Güttler, Steffen; Hartung, Evelyn; Ebstein, Frédéric; Schaefer, Michael; Tannert, Astrid; Salama, Abdulgabar; Movassaghi, Kamran; Opitz, Corinna; Mages, Hans Werner; Henn, Volker; Kloetzel, Peter-Michael; Gurka, Stephanie; Kroczek, RichardIn recent years, human dendritic cells (DCs) could be subdivided into CD304+ plasmacytoid DCs (pDCs) and conventional DCs (cDCs), the latter encompassing the CD1c+, CD16+, and CD141+ DC subsets. To date, the low frequency ...