- edoc-Server Home
- Browsing by Author
Browsing by Author "Brune, Wolfram"
Now showing items 1-9 of 9
-
2012-12-30ZeitschriftenartikelComplete Genome Sequence of the English Isolate of Rat Cytomegalovirus (Murid Herpesvirus 8) Ettinger, Jakob; Geyer, Henriette; Nitsche, Andreas; Zimmermann, Albert; Brune, Wolfram; Sandford, Gordon R.; Hayward, Gary S.; Voigt, SebastianThe complete genome of the English isolate of rat cytomegalovirus (RCMV-E) was determined. RCMV-E has a 202,946-bp genome with noninverting repeats but without terminal repeats. Thus, it differs significantly in size and ...
-
2011-07-27ZeitschriftenartikelConstruction of a lytically replicating Kaposi's sarcoma-associated herpesvirus (KSHV) Budt, Matthias; Histozova, Tsvetana; Hille, Georg; Berger, Katrin; Brune, WolframKarposi's sarcoma-associated herpesvirus (KSHV) is found predominantly in a latent state in most cell types, impeding investigations of the lytic replication cycle. Here, we engineered the cloned KSHV genome, bacterial ...
-
2013-08-08ZeitschriftenartikelCytomegalovirus Downregulates IRE1 to Repress the Unfolded Protein Response Stahl, Sebastian; Burkhart, Julia M.; Hinte, Florian; Tirosh, Boaz; Mohr, Hermine; Zahedi, René P.; Sickmann, Albert; Ruzsics, Zsolt; Budt, Matthias; Brune, WolframDuring viral infection, a massive demand for viral glycoproteins can overwhelm the capacity of the protein folding and quality control machinery, leading to an accumulation of unfolded proteins in the endoplasmic reticulum ...
-
2009-10-09ZeitschriftenartikelCytomegaloviruses inhibit Bak- and Bax-mediated apoptosis with two separate viral proteins Cam, M.; Handke, Wiebke; Picard-Maureau, M.; Brune, WolframApoptosis of infected cells can limit virus replication and serves as an innate defense mechanism against viral infections. Consequently, viruses delay apoptosis by expressing antiapoptotic proteins, many of which structurally ...
-
2009-11-18ZeitschriftenartikelDeletion of the rat cytomegalovirus immediate-early 1 gene results in a virus capable of establishing latency, but with lower levels of acute virus replication and latency that compromise reactivation efficiency Sandford, Gordon R.; Schumacher, Uwe; Ettinger, Jakob; Brune, Wolfram; Hayward, Gary S.; Burns, William H.; Voigt, SebastianThe immediate-early 1 (IE1) and IE2 proteins encoded by the major immediate-early (MIE) transcription unit of cytomegaloviruses are thought to play key roles in the switch between latent- and lytic-cycle infection. Whilst ...
-
2009-11-18ZeitschriftenartikelDeletion of the rat cytomegalovirus immediate-early 1 gene results in a virus capable of establishing latency, but with lower levels of acute virus replication and latency that compromise reactivation efficiency. Sandford, Gordon R.; Schumacher, Uwe; Ettinger, Jakob; Brune, Wolfram; Hayward, Gary S.; Burns, William H.; Voigt, SebastianThe IE1 and IE2 proteins encoded by the major immediate-early (MIE) transcription unit of cytomegaloviruses are thought to play key roles in the switch between latent and lytic cycle infection. Whilst IE2 is essential for ...
-
2014-01-30ZeitschriftenartikelMolecular Analysis of Human Metapneumovirus Detected in Patients with Lower Respiratory Tract Infection in Upper Egypt Mohamed, Mona S. Embarek; Reiche, Janine; Jacobsen, Sonja; Thabit, Amany G.; Badary, Mohamed S.; Brune, Wolfram; Schweiger, Brunhilde; Osmann, Ahmed H.Introduction: Since 2001, when Human metapneumovirus (HMPV) was isolated in the Netherlands, the virus has been detected in several continents. Although reports have confirmed the prevalence of HMPV worldwide, data from ...
-
2010-06-02ZeitschriftenartikelMutations in the M112/M113-coding region facilitate murine cytomegalovirus replication in human cells. Schumacher, Uwe; Handke, Wiebke; Jurak, Igor; Brune, WolframCytomegaloviruses, representatives of the Betaherpesvirinae, cause opportunistic infections in immunocompromised hosts. They infect various cells and tissues in their natural host but are highly species specific. For ...
-
2008-11-19ZeitschriftenartikelSpecific Inhibition of the PKR-Mediated Antiviral Response by the Murine Cytomegalovirus Proteins m142 and m143 Budt, Matthias; Niederstadt, Lars; Valchanova, Ralitsa S.; Jonjic, Stipan; Brune, WolframDouble-stranded RNA (dsRNA) produced during viral infection activates several cellular antiviral responses. Among the best characterized is the shutoff of protein synthesis mediated by the dsRNA-dependent protein kinase ...