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Auflistung nach Autor "Kroczek, Richard"
Anzeige der Publikationen 1-13 von 13
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2014-07-29ZeitschriftenartikelAntigen Export during Liver Infection of the Malaria Parasite Augments Protective Immunity Montagna, Georgina N.; Beigier-Bompadre, Macarena; Becker, Martina; Kroczek, Richard; Kaufmann, Stefan H. E.; Matuschewski, KaiProtective immunity against preerythrocytic malaria parasite infection is difficult to achieve. Intracellular Plasmodium parasites likely minimize antigen presentation by surface-expressed major histocompatibility complex ...
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2013-10-23ZeitschriftenartikelCytomegalovirus expresses the chemokine homologue vXCL1 capable of attracting XCR1+CD4- dendritic cells Geyer, Henriette; Hartung, Evelyn; Mages, Hans Werner; Weise, Christoph; Belužić, Robert; Vugrek, Oliver; Jonjić, Stipan; Kroczek, Richard; Voigt, SebastianCytomegaloviruses (CMV) have developed various strategies to escape the immune system of the host. One strategy involves the expression of virus-encoded chemokines to modulate the host chemokine network. We have identified ...
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2003-01-01ZeitschriftenartikelExpression of ICOS In Vivo Defines CD4+ Effector T Cells with High Inflammatory Potential and a Strong Bias for Secretion of Interleukin 10 Löhning, Max; Hutloff, Andreas; Kallinich, Tilmann; Mages, Hans Werner; Bonhagen, Kerstin; Radbruch, Andreas; Hamelmann, Eckard; Kroczek, RichardThe studies performed to date analyzed the overall participation of the inducible costimulator (ICOS) in model diseases, but did not yield information on the nature and function of ICOS-expressing T cells in vivo. We ...
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2012-07-18ZeitschriftenartikelExpression of XCR1 characterizes the Batf3-dependent lineage of dendritic cells capable of antigen cross-presentation Bachem, Annabell; Hartung, Evelyn; Güttler, Steffen; Mora, Ahmed; Zhou, Xuefei; Hegemann, Anika; Plantinga, Maud; Mazzini, Elisa; Stoitzner, Patrizia; Gurka, Stephanie; Henn, Volker; Mages, Hans Werner; Kroczek, RichardCross-presentation of antigen by dendritic cells (DCs) to CD8+ T cells is a fundamentally important mechanism in the defense against pathogens and tumors. Due to the lack of an appropriate lineage marker, cross-presenting ...
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2010-05-24ZeitschriftenartikelInducible costimulator (ICOS) blockade inhibits accumulation of polyfunctional T helper 1/T helper 17 cells and mitigates autoimmune arthritis Frey, Oliver; Meisel, Juliane; Hutloff, Andreas; Bonhagen, Kerstin; Bruns, Lisa; Kroczek, Richard; Morawietz, Lars; Kamradt, ThomasObjectives: Inducible costimulator (ICOS) and its ligand (ICOSL) regulate T and B cell responses. Glucose-6-phosphate isomerase (G6PI)-induced arthritis requires T and B lymphocytes. It was hypothesised that blocking ...
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2016-02-26ZeitschriftenartikelLocal T/B cooperation in inflamed tissues is supported by T follicular helper-like cells Van, Dana Vu; Beier, Katja C.; Pietzke, Lea-Jean; Baz, Maysun S. Al; Feist, Randi K.; Gurka, Stephanie; Hamelmann, Eckard; Kroczek, Richard; Hutloff, AndreasAutoimmune diseases and other inflammatory conditions are characterized by large lymphocytic tissue infiltrates in which T and B cells can be found in close contact. Here, using a murine airway inflammation model, we compare ...
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2014-05-21ZeitschriftenartikelLymph-borne CD8α+ dendritic cells are uniquely able to cross-prime CD8+ T cells with antigen acquired from intestinal epithelial cells Cerovic, V.; Houston, S. A.; Westlund, J.; Utriainen, L.; Davison, E. S.; Scott, C. L.; Bain, C. C.; Joeris, T.; Agace, W. W.; Kroczek, Richard; Mowat, A. M.; Yrlid, U.; Milling, S. W. F.Cross-presentation of cellular antigens is crucial for priming CD8+ T cells, and generating immunity to intracellular pathogens—particularly viruses. It is unclear which intestinal phagocytes perform this function in vivo. ...
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2015-02-04ZeitschriftenartikelMouse conventional dendritic cells can be universally classified based on the mutually exclusive expression of XCR1 and SIRPα Gurka, Stephanie; Hartung, Evelyn; Becker, Martina; Kroczek, RichardSince the identification of mouse dendritic cells (DC) in the early 70s, all attempts to consistently classify the identified functional DC subpopulations according to their surface molecule expression failed. In the absence ...
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2014-07-28ZeitschriftenartikelOntogenic, phenotypic, and functional characterization of XCR1+ dendritic cells leads to a consistent classification of intestinal dendritic cells based on the expression of XCR1 and SIRPα Becker, Martina; Güttler, Steffen; Bachem, Annabell; Hartung, Evelyn; Mora, Ahmed; Jäkel, Anika; Hutloff, Andreas; Henn, Volker; Mages, Hans Werner; Gurka, Stephanie; Kroczek, RichardIn the past, lack of lineage markers confounded the classification of dendritic cells (DC) in the intestine and impeded a full understanding of their location and function. We have recently shown that the chemokine receptor ...
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1999-02-01ZeitschriftenartikelRegelung des Blutspendewesens Nationale und Europäische Einrichtungen, Vorschriften und Empfehlungen im Bereich der Transfusionsmedizin und HämotherapieKroczek, Richard; Burger, Reinhard; Seitz, R.Dieser Beitrag beschreibt die verschiedenen nationalen und europäischen Institutionen, Kommittees, Zulassungsbehörden und Richtlinien, die das deutsche Transfusionssystem regulieren und die für dessen Qualitäts- und ...
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2018-12-13ZeitschriftenartikelStructure-Function Relationship of XCL1 Used for in vivo Targeting of Antigen Into XCR1+ Dendritic Cells Kroczek, Arthur L.; Hartung, Evelyn; Gurka, Stephanie; Becker, Martina; Reeg, Nele; Mages, Hans Werner; Voigt, Sebastian; Freund, Christian; Kroczek, RichardXCL1 is the ligand for XCR1, a chemokine receptor uniquely expressed on crosspresenting dendritic cells (DC) in mouse and man. We are interested in establishing therapeutic vaccines based on XCL1-mediated targeting of ...
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2010-05-17ZeitschriftenartikelSuperior antigen cross-presentation and XCR1 expression define human CD11c+CD141+ cells as homologues of mouse CD8+ dendritic cells Bachem, Annabell; Güttler, Steffen; Hartung, Evelyn; Ebstein, Frédéric; Schaefer, Michael; Tannert, Astrid; Salama, Abdulgabar; Movassaghi, Kamran; Opitz, Corinna; Mages, Hans Werner; Henn, Volker; Kloetzel, Peter-Michael; Gurka, Stephanie; Kroczek, RichardIn recent years, human dendritic cells (DCs) could be subdivided into CD304+ plasmacytoid DCs (pDCs) and conventional DCs (cDCs), the latter encompassing the CD1c+, CD16+, and CD141+ DC subsets. To date, the low frequency ...
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2012-02-10ZeitschriftenartikelThe role of XCR1 and its ligand XCL1 in antigen cross-presentation by murine and human dendritic cells Kroczek, Richard; Henn, VolkerRecently, the chemokine receptor XCR1 has been found to be exclusively expressed on a subset of dendritic cell (DC) known to be involved in antigen cross-presentation. This review aims to summarize the known biology of the ...