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2016-02-26Zeitschriftenartikel DOI: 10.1038/ncomms10875
Local T/B cooperation in inflamed tissues is supported by T follicular helper-like cells
Van, Dana Vu
Beier, Katja C.
Pietzke, Lea-Jean
Baz, Maysun S. Al
Feist, Randi K.
Gurka, Stephanie
Hamelmann, Eckard
Kroczek, Richard
Hutloff, Andreas
Autoimmune diseases and other inflammatory conditions are characterized by large lymphocytic tissue infiltrates in which T and B cells can be found in close contact. Here, using a murine airway inflammation model, we compare antigen-specific T and B cells in lung tissue versus lung-draining lymph node. In the lung we identify a B-cell population exhibiting a classical germinal centre phenotype without being organized into ectopic lymphoid tissue. By contrast, classical CXCR5+ Bcl-6+ T follicular helper cells are not present. Nevertheless, lung-infiltrating T cells exhibit follicular helper-like properties including the potential to provide help to naive B cells. The lung tissue is also a survival niche for memory T and B cells remaining in residual peribronchial infiltrates after resolution of inflammation. Collectively, this study shows the importance of T/B cooperation not only in lymph nodes but also in inflamed peripheral tissues for local antibody responses to infection and autoimmunity.
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DOI
10.1038/ncomms10875
Permanent URL
https://doi.org/10.1038/ncomms10875
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<a href="https://doi.org/10.1038/ncomms10875">https://doi.org/10.1038/ncomms10875</a>