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2020-11-12ZeitschriftenartikelDifferential Efficacy of Novel Antiviral Substances in 3D and Monolayer Cell Culture Repurposing of approved drugs that target host functions also important for virus replication promises to overcome the shortage of antiviral therapeutics. Mostly, virus biology including initial screening of antivirals is ...
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2020-01-21ZeitschriftenartikelThe European tiered approach for virucidal efficacy testing – rationale for rapidly selecting disinfectants against emerging and re-emerging viral diseases When facing an emerging virus outbreak such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a quick reaction time is key to control the spread. It takes time to develop antivirals and vaccines, and implement ...
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2020-12-19ZeitschriftenartikelHow Many Older Informal Caregivers Are There in Europe? Comparison of Estimates of Their Prevalence from Three European Surveys Informal caregivers are people providing some type of unpaid, ongoing assistance to a person with a chronic illness or disability. Long-term care measures and policies cannot take place without taking into account the ...
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2020-12-04ZeitschriftenartikelRe-assembly of nineteenth-century smallpox vaccine genomes reveals the contemporaneous use of horsepox and horsepox-related viruses in the USA According to a recent article published in Genome Biology, Duggan and coworkers sequenced and partially assembled five genomes of smallpox vaccines from the nineteenth century. No information regarding the ends of genomes ...
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2020-12-24ZeitschriftenartikelFirst detection of bat-borne Issyk-Kul virus in Europe Bats have been gaining attention as potential reservoir hosts of numerous viruses pathogenic to animals and man. Issyk-Kul virus, a member of the family Nairoviridae, was first isolated in the 1970s from vespertilionid ...
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2020-12-31ZeitschriftenartikelReflections on key methodological decisions in national burden of disease assessments Background: Summary measures of population health are increasingly used in different public health reporting systems for setting priorities for health care and social service delivery and planning. Disability-adjusted ...
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2021-01-01ZeitschriftenartikelHeteromultivalent topology-matched nanostructures as potent and broad-spectrum influenza A virus inhibitors Here, we report the topology-matched design of heteromultivalent nanostructures as potent and broad-spectrum virus entry inhibitors based on the host cell membrane. Initially, we investigate the virus binding dynamics to ...
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2020-10-08ZeitschriftenartikelA decade of de novo transcriptome assembly: Are we there yet? A decade ago, de novo transcriptome assembly evolved as a versatile and powerful approach to make evolutionary assumptions, analyse gene expression, and annotate novel transcripts, in particular, for non‐model organisms ...
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2020-10-09ZeitschriftenartikelMonoklonale Antikörper zur antiinfektiven Therapie Ein Jahrhundert lang wurde die Serumtherapie von Seren tierischen Ursprungs und Hyperimmunglobulinen dominiert. Obwohl seit Ende der Achtzigerjahre des letzten Jahrhunderts zahlreiche monoklonale Antikörper (MAB) insbesondere ...
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2020-12-22ZeitschriftenartikelSurgical hand preparation in an equine hospital: Comparison of general practice with a standardised protocol and characterisation of the methicillin-resistant Staphylococcus aureus recovered Presurgical hand asepsis is part of the daily routine in veterinary medicine. Nevertheless, basic knowledge seems to be low, even among specialised veterinary surgeons. The major objectives of our study were to assess ...
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2021-01-06ZeitschriftenartikelExcess mortality in adults with documented diabetes in Germany: routine data analysis of all insurance claims in Germany 2013–2014 Objectives: Little is known about the age-specific excess mortality pattern of people with diagnosed diabetes in Germany. Thus, our goal was to determine the excess mortality in diagnosed diabetes overall and stratified ...
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2021-01-11ZeitschriftenartikelAssessing the occurrence of the novel zoonotic variegated squirrel bornavirus 1 in captive squirrels in Germany —A prevalence study The newly described zoonotic variegated squirrel bornavirus 1 (VSBV‐1) in German squirrel holdings has been associated with the death of three private owners and one zoo animal caretaker (confirmed cases). Epidemiological ...
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2020-12-29ZeitschriftenartikelExcellent performance of CHROMagarTM LIN-R to selectively screen for linezolid-resistant enterococci and staphylococci The increasing number of nosocomial pathogens with resistances against last resort antibiotics like linezolid leads to a pressing need for the reliable detection of these drug-resistant bacteria. National guidelines ...
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2021-01-08ZeitschriftenartikelDemokratisch und emanzipatorisch – Partizipative Gesundheitsforschung hat hohes Potenzial
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2021-01-08ZeitschriftenartikelHypervirulent Klebsiella pneumoniae of Lineage ST66-K2 Caused Tonsillopharyngitis in a German Patient Hypervirulent Klebsiella pneumoniae (hvKp) is a novel pathotype that has been rarely described in Europe. This study characterizes a hvKp isolate that caused a community-acquired infection. The hypermucoviscous Klebsiella ...
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2020-12-18ZeitschriftenartikelGenetic Diversity of the Flavohemoprotein Gene of Giardia lamblia: Evidence for High Allelic Heterozygosity and Copy Number Variation Purpose: The flavohemoprotein (gFlHb) in Giardia plays an important role in managing nitrosative and oxidative stress, and potentially also in virulence and nitroimidazole drug tolerance. The aim of this study was to analyze ...
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2021-01-19ZeitschriftenartikelAssessment of the Effects of Active Immunisation against Respiratory Syncytial Virus (RSV) using Decision-Analytic Models: A Systematic Review with a Focus on Vaccination Strategies, Modelling Methods and Input Data Background: Several vaccine and antibody candidates are currently in development for the prevention of lower respiratory tract infections caused by the respiratory syncytial virus (RSV). Methods: We searched MEDLINE, ...
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2020-12-16ZeitschriftenartikelWie lässt sich die Eliminierung von Hepatitis B, C und D in Deutschland messen? Ergebnisse eines interdisziplinären Arbeitstreffens Hintergrund: Die Weltgesundheitsorganisation (WHO) hat 2016 eine Strategie zur Eliminierung von Hepatitis-B-, -C- und -D-Virusinfektionen verfasst und Indikatoren zum Monitoring des Fortschritts definiert. Das Robert ...
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2021-01-21ZeitschriftenartikelMehrere Listeriose-Ausbrüche in Deutschland mit Hinweisen auf geräucherte oder gebeizte Lachsprodukte als Ursache von Infektionen Listeriose, verursacht durch das Bakterium Listeria (L.) monocytogenes, tritt in verschiedenen Formen auf und wird vor allem durch Konsum kontaminierter Lebensmittel übertragen. Die Krankheit ist mit teilweise schweren ...
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2020-12-11ZeitschriftenartikelPopulation change and the burden of hospitalization in Germany 2000–2040: Decomposition analysis and projection Demographic factors, such as population aging and shrinkage, and non-demographic factors, such as hospitalization rate and length of hospital stay, generate challenges for inpatient care. This paper used decomposition ...