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2018-07-16ZeitschriftenartikelIncreasing influenza and pneumococcal vaccine uptake in the elderly: study protocol for the multi-methods prospective intervention study Vaccination60+ Background: Influenza and pneumococcal vaccination can prevent disease and potentially life-threatening complications like sepsis. Elderly people have an increased risk of severe disease and therefore constitute a major ...
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2018-06-22ZeitschriftenartikelThe Expression of Uncoupling Protein 3 Coincides With the Fatty Acid Oxidation Type of Metabolism in Adult Murine Heart The involvement of mitochondrial uncoupling proteins 2 and 3 in the pathogenesis of cardiovascular diseases is widely acknowledged. However, contradictory reports show that the functions of UCP2/UCP3 are still disputed. ...
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2018-06-14ZeitschriftenartikelSmear Microscopy for Diagnosis of Pulmonary Tuberculosis in Eastern Sudan Background. In Sudan, tuberculosis diagnosis largely relies on clinical symptoms and smear microscopy as in many other low- and middle-income countries. The aim of this study was to investigate the positive predictive value ...
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2018-06-15ZeitschriftenartikelESBL-plasmid carriage in E. coli enhances in vitro bacterial competition fitness and serum resistance in some strains of pandemic sequence types without overall fitness cost Background: Extended spectrum beta lactamase (ESBL)-producing extraintestinal pathogenic Escherichia coli infections are of global interest because of their clinical and economic impact. The ESBL resistance genes disseminate ...
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2018-06-14ZeitschriftenartikelMultispecies and Clonal Dissemination of OXA-48 Carbapenemase in Enterobacteriaceae From Companion Animals in Germany, 2009—2016 The increasing spread of carbapenemase-producing Enterobacteriaceae (CPE) poses a serious threat to public health. Recent studies suggested animals as a putative source of such bacteria. We investigated 19,025 Escherichia ...
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2018-06-27ZeitschriftenartikelHuman coronavirus OC43 outbreak in wild chimpanzees, Côte d´Ivoire, 2016
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2018-06-12ZeitschriftenartikelHigh genomic diversity of multi-drug resistant wastewater Escherichia coli Wastewater treatment plants play an important role in the emergence of antibiotic resistance. They provide a hot spot for exchange of resistance within and between species. Here, we analyse and quantify the genomic diversity ...
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2018-05-18ZeitschriftenartikelEasy and accurate reconstruction of whole HIV genomes from short-read sequence data with shiver Studying the evolution of viruses and their molecular epidemiology relies on accurate viral sequence data, so that small differences between similar viruses can be meaningfully interpreted. Despite its higher throughput ...
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2018-05-02ZeitschriftenartikelIntegration von Sekundärdaten in die Nationale Diabetes-Surveillance Hintergrund, Ziele und Ergebnisse des Sekundärdaten-Workshops am Robert Koch-InstitutEpidemiologische Daten belegen, dass Diabetes mellitus in Deutschland wie in vielen anderen Ländern eine hohe Public-health-Relevanz hat. Am Robert Koch-Institut (RKI) wird derzeit eine Nationale Diabetes-Surveillance ...
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2018-08-24ZeitschriftenartikelEvaluation of the statutory surveillance system for invasive MRSA infections in Germany, 2016–2017 Background: Mandatory notification of invasive methicillin-resistant Staphylococcus aureus (MRSA) infections was introduced for laboratories in Germany in 2009. The aims were to support local health authorities (LHAs) in ...
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2018-08-23ZeitschriftenartikelEmpfehlungen der Ständigen Impfkommission (STIKO) beim Robert Koch-Institut – 2018/2019 Die Impfempfehlungen der STIKO wurden auf der 88. bis 90. Sitzung der STIKO verabschiedet. Die folgenden Ausführungen ersetzen die im Epidemiologischen Bulletin des RKI (Epid. Bull.) 34/2017 veröffentlichten Impfempfehlungen. ...
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2018-09-13ZeitschriftenartikelEine deutschlandweite Befragung zur Organisation von regionalen Netzwerktreffen Eine erfolgreiche Zusammenarbeit in regionalen MRE-Netzwerken (MRE – multiresistente Erreger) beruht unter anderem auf dem aktiven Austausch der Netzwerkakteure in regelmäßig stattfindenden Treffen. Mit einer ...
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2018-05-23ZeitschriftenartikelHDV infection rates in northern Vietnam Hepatitis D caused by the hepatitis delta virus (HDV) is a serious health problem in many regions of the world. A total of 546 HBV-infected patients were enrolled from 2013 to 2015 and classified clinically into the subgroups ...
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2018-06-05ZeitschriftenartikelCarbapenem non-susceptibility of Klebsiella pneumoniae isolates in hospitals from 2011 to 2016, data from the German Antimicrobial Resistance Surveillance (ARS) Background: Carbapenem resistance in Klebsiella pneumoniae is of significant public health concern and recently spread across several countries. We investigated the extent of carbapenem non-susceptibility in K. pneumoniae ...
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2018-07-12ZeitschriftenartikelAbsence of IL-10 production by human PBMCs co-cultivated with human cells expressing or secreting retroviral immunosuppressive domains Immunosuppression by retroviruses including the human immunodeficiency virus—1 (HIV-1) is well known, however the mechanisms how retroviruses induce this immunosuppression is not fully investigated. It was shown that ...
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2018-07-10ZeitschriftenartikelDo adolescents understand the items of the European Health Literacy Survey Questionnaire (HLS-EU-Q47) – German version? Findings from cognitive interviews of the project “Measurement of Health Literacy Among Adolescents” (MOHLAA) in Germany Background: In Germany, there are no measurement tools to assess the general health literacy of adolescents. The aim of the study “Measurement of Health Literacy Among Adolescents” (MOHLAA) is to develop such a tool for ...
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2018-05-09ZeitschriftenartikelIs there a duty to participate in digital epidemiology? This paper poses the question of whether people have a duty to participate in digital epidemiology. While an implied duty to participate has been argued for in relation to biomedical research in general, digital epidemiology ...
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2018-05-10ZeitschriftenartikelDraft Genome Sequences of Plant-Associated Bacillus Strains Isolated from the Qinghai-Tibetan Plateau Here, we report the draft genome sequences of 45 plant-associated Bacillus strains isolated from the Qinghai-Tibetan plateau. According to their genome sequences, 28 isolates were assigned to 10 Bacillus species. Seventeen ...
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2018-05-02ZeitschriftenartikelA lipid-binding loop of botulinum neurotoxin serotypes B, DC and G is an essential feature to confer their exquisite potency The exceptional toxicity of botulinum neurotoxins (BoNTs) is mediated by high avidity binding to complex polysialogangliosides and intraluminal segments of synaptic vesicle proteins embedded in the presynaptic membrane. ...
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2018-05-15ZeitschriftenartikelImmunity levels to poliovirus in Lao children and adults before the vaccine-derived poliovirus outbreak: A retrospective study In 2015, several provinces in Lao People's Democratic Republic (Lao PDR) experienced a vaccine-derived poliovirus outbreak. This survey was conducted (i) to evaluate the vaccination coverage in different settings and cohorts ...