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2022-08-04ZeitschriftenartikelWie gut und wie lange schützt eine SARS-CoV-2-Infektion vor einer Reinfektion? Die COVID-19-Pandemie ist durch ein dynamisches Infektions- und Krankheitsgeschehen gekennzeichnet, u. a. bedingt durch die Entstehung neuer Virusvarianten mit teilweise veränderten Übertragungseigenschaften. Daher ist die ...
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2022-07-28ZeitschriftenartikelVirushepatitis B und D im Jahr 2021 Hepatitis B ist eine der häufigsten Infektionskrankheiten weltweit und im Fall eines chronischen Verlaufs eine der bedeutendsten Ursachen von Leberzirrhose und Leberzellkarzinom. Auch Hepatitis D kommt weltweit vor. ...
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2022-03-11ZeitschriftenartikelIdentification of Mucormycosis by Fluorescence In Situ Hybridization Targeting Ribosomal RNA in Tissue Samples Mucormycosis is an invasive fungal infection associated with high mortality, partly due to delayed diagnosis and inadequate empiric therapy. As fungal cultures often fail to grow Mucorales, identification of respective ...
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2021-12-16ZeitschriftenartikelContext-aware genomic surveillance reveals hidden transmission of a carbapenemase-producing Klebsiella pneumoniae Genomic surveillance can inform effective public health responses to pathogen outbreaks. However, integration of non-local data is rarely done. We investigate two large hospital outbreaks of a carbapenemase-carrying ...
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2022-01-04ZeitschriftenartikelInvestigation of a Limited but Explosive COVID-19 Outbreak in a German Secondary School The role of schools as a source of infection and driver in the coronavirus-pandemic has been controversial and is still not completely clarified. To prevent harm and disadvantages for children and adolescents, but also ...
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2022-01-14ZeitschriftenartikelSARS-CoV-2 outbreaks in hospitals and long-term care facilities in Germany: a national observational study Background: Outbreaks of coronavirus disease (COVID-19) in hospitals and long-term care facilities (LTCFs) pose serious public health threats. We analysed how frequency and size of SARS-CoV-2 outbreaks in hospitals and ...
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2022-01-19ZeitschriftenartikelLateral flow–based nucleic acid detection of SARS-CoV-2 using enzymatic incorporation of biotin-labeled dUTP for POCT use The degree of detrimental effects inflicted on mankind by the COVID-19 pandemic increased the need to develop ASSURED (Affordable, Sensitive, Specific, User-friendly, Rapid and Robust, Equipment-free, and Deliverable) POCT ...
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2022-06-05ZeitschriftenartikelSeroprevalence of Measles-, Mumps-, and Rubella-specific antibodies in the German adult population – cross-sectional analysis of the German Health Interview and Examination Survey for Adults (DEGS1) Background: The WHO European Region targets the elimination of measles, rubella, and the congenital rubella syndrome and welcomes mumps elimination via the joint MMR vaccine. In a push towards this elimination goal, Germany ...
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2022-01-14ZeitschriftenartikelCOVID-19 infections in day care centres in Germany: social and organisational determinants of infections in children and staff in the second and third wave of the pandemic Background: During the SARS-CoV-2 pandemic, German early childhood education and care (ECEC) centres organised children’s attendance in different ways, they reduced opening hours, provided emergency support for a few ...
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2022-07-21ZeitschriftenartikelCOVID-19-Pandemie: Surveillance und Studien des Robert Koch-Instituts zur Lage- und Maßnahmenbewertung Als nationales Public-Health-Institut überwacht und analysiert das RKI die Verbreitung übertragbarer und nicht übertragbarer Krankheiten in Deutschland. Im Rahmen der COVID-19-Pandemie wurden die bestehenden Surveillance-Systeme ...
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2022-07-19ZeitschriftenartikelWeltweiter Ausbruch von Affenpocken - Situationsbeschreibung des Robert Koch-Instituts für Deutschland, Datenstand 14.07.2022 Im Mai 2022 häuften sich nicht-reiseassoziierte Fälle von Affenpocken. Seitdem hat sich ein weltweiter Ausbruch mit über 11.000 Fällen in 69 Ländern entwickelt, von denen rund 80 % in Europa gemeldet wurden. In Deutschland ...
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2022-02-21ZeitschriftenartikelThe first WHO global survey on infection prevention and control in health-care facilities Background: WHO core components for infection prevention and control (IPC) are important building blocks for effective IPC programmes. To our knowledge, we did the first WHO global survey to assess implementation of these ...
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2022-06-02ZeitschriftenartikelSARS-CoV-2 Omicron variants BA.1 and BA.2 both show similarly reduced disease severity of COVID-19 compared to Delta, Germany, 2021 to 2022 German national surveillance data analysis shows that hospitalisation odds associated with Omicron lineage BA.1 or BA.2 infections are up to 80% lower than with Delta infection, primarily in ≥ 35-year-olds. Hospitalised ...
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2022-06-02ZeitschriftenartikelEvolutionarily stable gene clusters shed light on the common grounds of pathogenicity in the Acinetobacter calcoaceticus-baumannii complex Nosocomial pathogens of the Acinetobacter calcoaceticus-baumannii (ACB) complex are a cautionary example for the world-wide spread of multi- and pan-drug resistant bacteria. Aiding the urgent demand for novel therapeutic ...
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2022-05-25ZeitschriftenartikelA Federated and Distributed Data Management Infrastructure to Enable Public Health Surveillance from Intensive Care Unit Data The Robert Koch Institute (RKI) monitors the actual number of COVID-19 patients requiring intensive care from aggregated data reported by hospitals in Germany. So far, there is no infrastructure to make use of individual ...
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2022-07-14ZeitschriftenartikelInfektionsquellensuche bei ambulant erworbenen Fällen von Legionärskrankheit – Ergebnisse der LeTriWa-Studie; Berlin, 2016–2020 Hintergrund/Zielsetzung: Bei ambulant erworbenen Fällen von Legionärskrankheit (AE-LK) ist die Infektionsquelle meistens unbekannt. Es wird vermutet, dass mit Legionellen kontaminiertes häusliches Trinkwasser eine häufige ...
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2022-07-14ZeitschriftenartikelInfektionsquellensuche bei ambulant erworbenen Fällen von Legionärskrankheit – Ergebnisse der LeTriWa-Studie; Berlin, 2016 – 2020 – Teil 2 (Ergebnisse und Diskussion) Im Rahmen der Berliner LeTriWa-Studie („Legionellen in der Trinkwasser-Installation“) versuchten wir, ambulant erworbene Fälle von Legionärskrankheit (AE-LK) evidenzbasiert einer Infektionsquelle zuzuordnen. Dafür wurde ...
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2022-05-05ZeitschriftenartikelThe International Virus Bioinformatics Meeting 2022 The International Virus Bioinformatics Meeting 2022 took place online, on 23–25 March 2022, and has attracted about 380 participants from all over the world. The goal of the meeting was to provide a meaningful and interactive ...
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2022-05-17ZeitschriftenartikelThe InfAct proposal for a sustainable European health information infrastructure on population health: the Distributed Infrastructure on Population Health (DIPoH) Background: In Europe, data on population health is fragmented, difficult to access, project-based and prone to health information inequalities in terms of availability, accessibility and especially in quality between and ...
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2022-03-09ZeitschriftenartikelCombined Clinical, Epidemiological, and Genome-Based Analysis Identified a Nationwide Outbreak of Burkholderia cepacia Complex Infections Caused by Contaminated Mouthwash Solutions Background: In September 2018, Burkholderia cepacia complex (BCC) infections in 3 patients associated with exposure to a mouthwash solution (MWS) were reported to the Robert Koch Institute (RKI). As the product was still ...