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2019-07-26ZeitschriftenartikelProficiency Testing of Virus Diagnostics Based on Bioinformatics Analysis of Simulated In Silico High-Throughput Sequencing Data Sets Quality management and independent assessment of high-throughput sequencing-based virus diagnostics have not yet been established as a mandatory approach for ensuring comparable results. The sensitivity and specificity of ...
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2019-06-21ZeitschriftenartikelPerceived diabetes risk and related determinants in individuals with high actual diabetes risk: results from a nationwide population-based survey Objective The purpose of this study was first, to examine perceived diabetes risk compared with actual diabetes risk in the general population and second, to investigate which factors determine whether persons at increased ...
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2019-06-04ZeitschriftenartikelMaternal Immunization and Antenatal Care Situation Analysis (MIACSA) study protocol: a multiregional, cross-sectional analysis of maternal immunization delivery strategies to reduce maternal and neonatal morbidity and mortality Introduction Maternal immunization (MI) with tetanus toxoid containing vaccine, is a safe and cost-effective way of preventing neonatal tetanus. Given the prospect of introducing new maternal vaccines in the near ...
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2019-08-13ZeitschriftenartikelEpidemiology and cost of seasonal influenza in Germany - a claims data analysis Background Seasonal influenza contributes substantially to the burden of communicable diseases in Europe, especially among paediatric populations and the elderly. The aim of the present study was to estimate the incidence ...
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2018-05-09ZeitschriftenartikelEpidemiologische Studien mit Umweltbezug in Deutschland Unsere Umwelt beeinflusst Gesundheit und Wohlbefinden des Menschen, von der Geburt bis ins hohe Alter. In diesem Überblick werden die wichtigsten epidemiologischen Studien und Gesundheitsmonitoringsysteme in Deutschland ...
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2018-09-06ZeitschriftenartikelNational public health system responses to diabetes and other important noncommunicable diseases Background, goals, and results of an international workshop at the Robert Koch InstituteDiabetes mellitus and other noncommunicable diseases (NCDs) represent an emerging global public health challenge. In Germany, about 6.7 million adults are affected by diabetes according to national health surveys, including ...
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2019-06-12ZeitschriftenartikelFirst-line tuberculosis drug resistance patterns and associated risk factors in Germany, 2008-2017 Background Drug-resistant tuberculosis (TB), especially multidrug-resistant TB (MDR-TB), poses a threat to public health. While standard surveillance focuses on Rifampicin and/or Isoniazid resistance, little is known about ...
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2019-07-23ZeitschriftenartikelWhere did you come from, where did you go: Refining metagenomic analysis tools for horizontal gene transfer characterisation Abstract Horizontal gene transfer (HGT) has changed the way we regard evolution. Instead of waiting for the next generation to establish new traits, especially bacteria are able to take a shortcut via HGT that enables ...
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2019-07-31ZeitschriftenartikelWhole genome-based public health surveillance of less common STEC serovars and untypable strains identifies four novel O genotypes Shiga toxin-producing E. coli (STEC) and the subgroup of enterohemorrhagic E. coli cause intestinal infections with symptoms ranging from watery diarrhea to hemolytic uremic syndrome (HUS). A key tool for epidemiological ...
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2019-08-22ZeitschriftenartikelEmpfehlungen der Ständigen Impfkommission beim Robert Koch-Institut – 2019/2020 Die Ständige Impfkommission (STIKO) hat ihre neuen Impfempfehlungen im Epidemiologischen Bulletin 34/2019 veröffentlicht. Die wesentliche Neuerung ist bereits in der Ausgabe 50/2018 veröffentlicht worden: Die STIKO empfiehlt ...
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2019-08-07ZeitschriftenartikelIndicator-based public health monitoring in old age in OECD member countries: a scoping review Background The scoping review was conducted as part of the project “Improving Health Monitoring in Old Age” (IMOA) which aims at developing a conceptual framework with key indicators for a public health monitoring of the ...
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2019-07-08ZeitschriftenartikelIncidence of advanced colorectal cancer in Germany: comparing claims data and cancer registry data Background Incidence rates of advanced cancer stages are important, e.g., for monitoring cancer screening programs. However, information from cancer registries on tumor stage is often incomplete. Exemplified by colorectal ...
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2019-08-05ZeitschriftenartikelLinks between transactional sex and HIV/STI-risk and substance use among a large sample of European men who have sex with men Background In Europe, the highest proportion of HIV diagnoses are in gay men and other men who have sex with men (MSM). Globally, HIV prevalence is particularly high among males who report selling sex, but rates among men ...
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2019-06-20ZeitschriftenartikelWhy all blood donations should be tested for hepatitis E virus (HEV) Background Hepatitis E is a liver disease caused by a small RNA virus known as hepatitis E virus (HEV). Four major genotypes infect humans, of which genotype 1 and 2 (HEV-1, HEV-2) are endemic mainly in Asia and responsible ...
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2019-07-22ZeitschriftenartikelSusceptibility of livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) to chlorhexidine digluconate, octenidine dihydrochloride, polyhexanide, PVP-iodine and triclosan in comparison to hospital-acquired MRSA (HA-MRSA) and community-aquired MRSA (CA-MRSA): a standardized comparison Background Recent publications have raised concerns of reduced susceptibilities of clinical bacterial isolates towards biocides. This study presents a comparative investigation of the susceptibility of livestock-associated ...
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2019-08-01ZeitschriftenartikelCytomegalovirus distribution and evolution in hominines Herpesviruses are thought to have evolved in very close association with their hosts. This is notably the case for cytomegaloviruses (CMVs; genus Cytomegalovirus) infecting primates, which exhibit a strong signal of ...
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2019-02-21ZeitschriftenartikelLaboratory Findings, Compassionate Use of Favipiravir, and Outcome in Patients With Ebola Virus Disease, Guinea, 2015—A Retrospective Observational Study Background In 2015, the laboratory at the Ebola treatment center in Coyah, Guinea, confirmed Ebola virus disease (EVD) in 286 patients. The cycle threshold (Ct) of an Ebola virus–specific reverse transcription–polymerase ...
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2019-08-22ZeitschriftenartikelAn evolutionary framework to guide the hunt for human dsDNA viruses It is becoming increasingly obvious that we only know a fraction of the human virome. The development of next-generation sequencing (NGS) technologies has dramatically increased our ability to hunt viruses. Yet, the small ...
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2019-09Teil eines BuchesChallenges in the Development of Reference Materials for Protein Toxins High molecular weight protein toxins produced by bacteria, e.g. staphylococcal enterotoxins and botulinum neurotoxins, as well as plant toxins such as ricin and abrin, are relevant analytes in different application areas: ...
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2018-09-19ZeitschriftenartikelAccident injuries of children and adolescents in Germany. Results of the cross-sectional KiGGS Wave 2 study and trends For children and adolescents, accidents represent an important health risk. Despite decreasing mortality rates, accidental (unintended) injuries remain the most common cause of death for children over the age of one in ...