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2019ZeitschriftenartikelThe Diagnosis and Treatment of Tuberculosis Background: Around 10 million people worldwide contract tuberculosis every year. According to the World Health Organization (WHO), approximately one-quarter of the world’s population is latently infected with Mycobacterium ...
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2019-01-02ZeitschriftenartikelAre European HIV cohort data within EoroCoord representative of the diagnosed HIV population? Objective: HIV cohorts are an important source of clinical data for informing public health policies and programmes. However, the generalizability of cohort findings to the wider population of people diagnosed with HIV ...
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2019-06-20ZeitschriftenartikelSystems-level Analysis Reveals Multiple Modulators of Epithelial-mesenchymal Transition and Identifies DNAJB4 and CD81 as Novel Metastatis Inducers in Breast Cancer Epithelial-mesenchymal transition (EMT) is driven by complex signaling events that induce dramatic biochemical and morphological changes whereby epithelial cells are converted into cancer cells. However, the underlying ...
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2019-04-30ZeitschriftenartikelExtended-Spectrum Beta-Lactamase (ESBL)-Producing Escherichia coli Isolated from Flies in the Urban Center of Berlin, Germany Background: The monitoring of antimicrobial resistance (AMR) in microorganisms that circulate in the environment is an important topic of scientific research and contributes to the development of action plans to combat the ...
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2019-12-30ZeitschriftenartikelRORγt+ Treg to Th17 ratios correlate with susceptibility to Giardia infection Infections with Giardia are among the most common causes of food and water-borne diarrheal disease worldwide. Here, we investigated Th17, Treg and IgA responses, and alterations in gut microbiota in two mouse lines with ...
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2018-04-11ZeitschriftenartikelOver-The-Counter (OTC) Drug Consumption among Adults Living in Germany: Results from the German Health Interview and Examination Survey for Adults 2008-2011 (DEGS1) In order to assess the effects of prescription-only (Rx) to over-the-counter (OTC) drug switches and related policies, it is imperative to distinguish self-medication from OTC drug use. The objective of this study was to ...
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2018-10-30ZeitschriftenartikelMetabolic interactions between Toxoplasma gondii an its host Toxoplasma gondii is an obligate intracellular parasite belonging to the phylum Apicomplexa that infects all warm-blooded animals, including humans. T. gondii can replicate in every nucleated host cell by orchestrating ...
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2018-11-01ZeitschriftenartikelUpsurge in echovirus 30 detections in five EU/EEA countries, April to September, 2018 An upsurge in Echovirus 30 (E30) infections, associated with meningitis/meningoencephalitis, has been observed in Denmark, Germany, the Netherlands, Norway and Sweden in the period April to September 2018, compared with ...
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2018-02ZeitschriftenartikelPrevalence and Clinical Correlates of Chronic Hepatitis E Infection in German Renal Transplant RecipientsWith Elevated Liver Enzymes Background Elevated liver enzymes are frequently observed in renal transplant recipients and warrant further exploration. In immunosuppressed patients, hepatitis E virus (HEV) infection may cause chronic hepatitis, ...
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2018-12ZeitschriftenartikelSurvey of Ebola Viruses in Frugivorous and Insectivorous Bats in Guinea, Cameroon, and the Democratic Rpublic of the Congo, 2015-2017 To clarify the role of bats in the ecology of Ebola viruses, we assessed the prevalence of Ebola virus antibodies in a large-scale sample of bats collected during 2015–2017 from countries in Africa that have had previous ...
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2018-05ZeitschriftenartikelDimerization of the cellular prion protein inhibits propagation of scrapie prions A central step in the pathogenesis of prion diseases is the conformational transition of the cellular prion protein (PrPC) into the scrapie isoform, denoted PrPSc. Studies in transgenic mice have indicated that this ...
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2018-08-01ZeitschriftenartikelCorrigendum: SeroBA: rapid high-throughput serotyping of Streptococcus pneumoniae from whole genome sequence data Streptococcus pneumoniae is responsible for 240 000–460 000 deaths in children under 5 years of age each year. Accurate identification of pneumococcal serotypes is important for tracking the distribution and evolution of ...
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2018-03ZeitschriftenartikelModel projections on the impact of HCV treatment in the prevention of HCV transmission among people who inject drugs in Europe Background & Aims Prevention of hepatitis C virus (HCV) transmission among people who inject drugs (PWID) is critical for eliminating HCV in Europe. We estimated the impact of current and scaled-up HCV treatment with and ...
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2018-09-10ZeitschriftenartikelFluorescence-Based Detection of Natural Transformation in Drug-Resistant Acinetobacter baumannii Acinetobacter baumannii is a nosocomial agent with a high propensity for developing resistance to antibiotics. This ability relies on horizontal gene transfer mechanisms occurring in the Acinetobacter genus, including ...
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2018-11-10ZeitschriftenartikelMeassuring progress from 1990 to 2017 and projecting attainment to 2030 of the health-related Sustainable Development Goals for 195 countries and territories: a systematic analysis for the Global Burden of Disease Study 2017 Background Efforts to establish the 2015 baseline and monitor early implementation of the UN Sustainable Development Goals (SDGs) highlight both great potential for and threats to improving health by 2030. To fully deliver ...
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2025-01-17ZeitschriftenartikelEditorial: Vaccine-preventable diseases in times of climate change, economic crisis, and pandemic preparedness — a call for new approaches and global equity
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2024-09-16ZeitschriftenartikelGlobal burden of bacterial antimicrobial resistance 1990–2021: a systematic analysis with forecasts to 2050 Background: Antimicrobial resistance (AMR) poses an important global health challenge in the 21st century. A previous study has quantified the global and regional burden of AMR for 2019, followed with additional publications ...
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2026-08-19ZeitschriftenartikelWhich population groups are more likely to get too little sleep? Results of the “German Health Update” (GEDA 2023) Background: Short sleep duration is associated with an increased health risk. Methods: The data are based on a Germany-wide, representative telephone survey of adults conducted as part of the Health Monitoring Programme ...
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2026-08-19ZeitschriftenartikelWelche Bevölkerungsgruppen schlafen eher zu wenig? Ergebnisse der Studie „Gesundheit in Deutschland aktuell“ (GEDA 2023) Hintergrund: Eine kurze Schlafdauer ist mit einem erhöhten Gesundheitsrisiko assoziiert. Methode: Die Daten basieren auf einer deutschlandweiten, repräsentativen, telefonischen Befragung von Erwachsenen im Rahmen des ...
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2026-08-19ZeitschriftenartikelPrevalence and trends in self-reported hearing difficulties among adults in Germany: Results from the GEDA study Background: Hearing is a fundamental ability for participating in everyday life. Hearing loss can substantially impair physical, emotional and social well-being and lead to social isolation. This study examines the prevalence, ...