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Auflistung nach Autor "Hölzer, Martin"
Anzeige der Publikationen 1-20 von 22
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2020-10-08ZeitschriftenartikelA decade of de novo transcriptome assembly: Are we there yet? Hölzer, MartinA decade ago, de novo transcriptome assembly evolved as a versatile and powerful approach to make evolutionary assumptions, analyse gene expression, and annotate novel transcripts, in particular, for non‐model organisms ...
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2020-10-08ZeitschriftenartikelA decade of de novo transcriptome assembly: Are we there yet? Hölzer, MartinA decade ago, de novo transcriptome assembly evolved as a versatile and power- ful approach to make evolutionary assumptions, analyse gene expression, and anno- tate novel transcripts, in particular, for non-model organisms ...
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2022-08-15ZeitschriftenartikelAdvancing Precision Vaccinology by Molecular and Genomic Surveillance of Severe Acute Respiratory Syndrome Coronavirus 2 in Germany, 2021 Oh, Djin-Ye; Hölzer, Martin; Paraskevopolou, Sofia; Tofimova, Maria; Hartkopf, Felix; Budt, Matthias; Wedde, Marianne; Richard, Hugues; Haldemann, Berit; Domaszewska, Teresa; Reiche, Janine; Keeren, Kathrin; Radonić, Aleksander; Ramos Calderón, Julia Patricia; Smith, Maureen Rebecca; Brinkmann, Annika; Trappe, Kathrin; Drechsel, Oliver; Klaper, Kathleen; Hein, Sascha; Hildt, Eberhardt; Haas, Walter; Calvignac-Spencer, Sébastien; Semmler, Torsten; Dürrwald, Ralf; Thürmer, Andrea; Drosten, Christian; Fuchs, Stephan; Kröger, Stefan; von Kleist, Max; Wolff, Thorsten; Integrated Molecular Surveillance for SARS-CoV-2 (IMS-SC2) Laboratory NetworkBackground Comprehensive pathogen genomic surveillance represents a powerful tool to complement and advance precision vaccinology. The emergence of the Alpha variant in December 2020 and the resulting efforts to track ...
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2022-03-03ZeitschriftenartikelAntibody escape and global spread of SARS-CoV-2 lineage A.27 Kaleta, Tamara; Kern, Lisa; Hong, Samuel Leandro; Hölzer, Martin; Kochs, Georg; Beer, Julius; Schnepf, Daniel; Schwemmle, Martin; Bollen, Nena; Kolb, Philipp; Huber, Magdalena; Ulferts, Svenja; Weigang, Sebastian; Dudas, Gytis; Alice, Wittig; Jaki, Lena; Padane, Abdou; Lagare, Adamou; Salou, Mounerou; Ozer, Egon Anderson; Nnaemeka, Ndodo; Odoom, John Kofi; Rutayisire, Robert; Benkahla, Alia; Akoua-Koffi, Chantal; Ouedraogo, Abdoul-Salam; Simon-Lorière, Etienne; Enouf, Vincent; Kröger, Stefan; Calvignac-Spencer, Sébastien; Baele, Guy; Panning, Marcus; Fuchs, JonasIn spring 2021, an increasing number of infections was observed caused by the hitherto rarely described SARS-CoV-2 variant A.27 in south-west Germany. From December 2020 to June 2021 this lineage has been detected in 31 ...
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2022-06-28ZeitschriftenartikelBAFFR activates PI3K/AKT signaling in human naive but not in switched memory B cells through direct interactions with B cell antigen receptors Sevdali, Eirini; Block, Violeta; Lataretu, Marie; Li, Huiying; Smulski, Christian R.; Briem, Jana-Susann; Heitz, Yannic; Fischer, Beate; Ramirez, Neftali-Jose; Grimbacher, Bodo; Jäck, Hans-Martin; Voll, Reinhard E.; Hölzer, Martin; Schneider, Pascal; Eibel, HermannBinding of BAFF to BAFFR activates in mature B cells PI3K/AKT signaling regulating protein synthesis, metabolic fitness, and survival. In humans, naive and memory B cells express the same levels of BAFFR, but only memory ...
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2022-07-14ZeitschriftenartikelComparative transcriptomics identifies candidate genes involved in the evolutionary transition from dehiscent to indehiscent fruits in Lepidium (Brassicaceae) Gramzow, Lydia; Klupsch, Katharina; Fernández-Pozo, Noé; Hölzer, Martin; Marz, Manja; Rensing, Stefan A.; Theißen, GünterBackground Fruits are the seed-bearing structures of flowering plants and are highly diverse in terms of morphology, texture and maturation. Dehiscent fruits split open upon maturation to discharge their seeds while ...
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2021-05-12ZeitschriftenartikelComparison of Illumina and Oxford Nanopore Technology for genome analysis of Francisella tularensis, Bacillus anthracis, and Brucella suis Linde, Jörg; Brangsch, Hanka; Hölzer, Martin; Thomas, Christine; Elschner, Mandy C.; Melzer, Falk; Tomaso, HerbertBackground Bacterial epidemiology needs to understand the spread and dissemination of strains in a One Health context. This is important for highly pathogenic bacteria such as Bacillus anthracis, Brucella species, and ...
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2020-11-04ZeitschriftenartikelComputational strategies to combat COVID-19: useful tools to accelerate SARS-CoV-2 and coronavirus research Hufsky, Franziska; Lamkiewicz, Kevin; Almeida, Alexandre; Aouacheria, Abdel; Arighi, Cecilia; Bateman, Alex; Baumbach, Jan; Beerenwinkel, Niko; Brandt, Christian; Cacciabue, Marco; Chuguransky, Sara; Drechsel, Oliver; Finn, Robert D; Fritz, Adrian; Fuchs, Stephan; Hattab, Georges; Hauschild, Anne-Christin; Heider, Dominik; Hoffmann, Marie; Hölzer, Martin; Hoops, Stefan; Kaderali, Lars; Kalvari, Ioanna; von Kleist, Max; Kmiecinski, Renó; Kühnert, Denise; Lasso, Gorka; Libin, Pieter; List, Markus; Löchel, Hannah F.; Martin, Maria J.; Martin, Roman; Matschinske, Julian; McHardy, Alice C.; Mendes, Pedro; Mistry, Jaina; Navratil, Vincent; Nawrocki, Eric P.; O'Toole, Áine Niamh; Ontiveros-Palacios, Nancy; Petrov, Anton I; Rangel-Pineros, Guillermo; Redaschi, Nicole; Reimering, Susanne; Reinert, Knut; Reyes, Alejandro; RIchardson, Lorna; Robertson, David L.; Sadegh, Sepideh; Singer, Joshua B.; Theys, Kristof; Upton, Chris; Welzel, Marius; Williams, Lowri; Marz, ManjaSARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is a novel virus of the family Coronaviridae. The virus causes the infectious disease COVID-19. The biology of coronaviruses has been studied for many years. ...
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2021-12-16ZeitschriftenartikelContext-aware genomic surveillance reveals hidden transmission of a carbapenemase-producing Klebsiella pneumoniae Viehweger, Adrian; Blumenscheit, Christian; Lippmann, Norman; Wyres, Kelly L.; Brandt, Christian; Hans, Jörg B.; Hölzer, Martin; Irber, Luiz; Gatermann, Sören; Lübbert, Christoph; Pletz, Mathias W.; Holt, Kathryn E.; König, BrigitteGenomic surveillance can inform effective public health responses to pathogen outbreaks. However, integration of non-local data is rarely done. We investigate two large hospital outbreaks of a carbapenemase-carrying ...
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2022-03-14ZeitschriftenartikelCorrigendum: poreCov - An Easy to Use, Fast, and Robust Workflow for SARS CoV-2 Genome Reconstruction via Nanopore Sequencing Brandt, Christian; Krautwurst, Sebastian; Spott, Riccardo; Lohde, Mara; Jundzill, Mateusz; Marquet, Mike; Hölzer, Martin
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2022-02-16ZeitschriftenartikelEditorial: The Transition Era to New Sequencing Technologies and Their Application to Integrative Omics in Molecular Surveillance Hölzer, Martin; Escobar-Zepeda, Alejandra; Linde, Jörg; Horn, Fabian
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2022-01-04ZeitschriftenartikelInvestigation of a Limited but Explosive COVID-19 Outbreak in a German Secondary School Baumgarte, Sigrid; Hartkopf, Felix; Hölzer, Martin; von Kleist, Max; Neitz, Sabine; Kriegel, Martin; Bollongino, KirstenThe role of schools as a source of infection and driver in the coronavirus-pandemic has been controversial and is still not completely clarified. To prevent harm and disadvantages for children and adolescents, but also ...
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2022-03-22ZeitschriftenartikelNear Chromosome-Level Genome Assembly and Annotation of Rhodotorula babjevae Strains Reveals High Intraspecific Divergence Martín-Hernández, Giselle C.; Müller, Bettina; Brandt, Christian; Hölzer, Martin; Viehweger, Adrian; Passoth, VolkmarThe genus Rhodotorula includes basidiomycetous oleaginous yeast species. Rhodotorula babjevae can produce compounds of biotechnological interest such as lipids, carotenoids, and biosurfactants from low value substrates ...
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2021-07-28ZeitschriftenartikelporeCov-An Easy to Use, Fast, and Robust Workflow for SARS-CoV-2 Genome Reconstruction via Nanopore Sequencing Brandt, Christian; Krautwurst, Sebastian; Spott, Riccardo; Lohde, Mara; Jundzill, Mateusz; Marquet, Mike; Hölzer, MartinIn response to the SARS-CoV-2 pandemic, a highly increased sequencing effort has been established worldwide to track and trace ongoing viral evolution. Technologies, such as nanopore sequencing via the ARTIC protocol are ...
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2021-07-21ZeitschriftenartikelRise and Fall of SARS-CoV-2 Lineage A.27 in Germany Calvignac-Spencer, Sébastien; Budt, Matthias; Huska, Matthew; Richard, Hugues; Leipold, Luca; Grabenhenrich, Linus; Semmler, Torsten; von Kleist, Max; Kröger, Stefan; Wolff, Thorsten; Hölzer, MartinHere, we report on the increasing frequency of the SARS-CoV-2 lineage A.27 in Germany during the first months of 2021. Genomic surveillance identified 710 A.27 genomes in Germany as of 2 May 2021, with a vast majority ...
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2020-12-10ZeitschriftenartikelRNAflow: An Effective and Simple RNA-Seq Differential Gene Expression Pipeline Using Nextflow Lataretu, Marie; Hölzer, MartinRNA-Seq enables the identification and quantification of RNA molecules, often with the aim of detecting differentially expressed genes (DEGs). Although RNA-Seq evolved into a standard technique, there is no universal gold ...
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2020-12-10ZeitschriftenartikelRNAflow: An Effective and Simple RNA-Seq Differential Gene Expression Pipeline Using Nextflow Lataretu, Marie; Hölzer, MartinRNA-Seq enables the identification and quantification of RNA molecules, often with the aim of detecting differentially expressed genes (DEGs). Although RNA-Seq evolved into a standard technique, there is no universal gold ...
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2021-01-26ZeitschriftenartikelRUNX3 Transcript Variants Have Distinct Roles in Ovarian Carcinoma and Differently Influence Platinum Sensitivity and Angiogenesis Heinze, Karolin; Hölzer, Martin; Ungelenk, Martin; Gerth, Melanie; Thomale, Jürgen; Heller, Regine; Morden, Claire R.; McManus, Kirk J.; Mosig, Alexander S.; Dürst, Matthias; Runnebaum, Ingo B.; Häfner, NormanThe prognosis of late-stage epithelial ovarian cancer (EOC) patients is affected by chemotherapy response and the malignant potential of the tumor cells. In earlier work, we identified hypermethylation of the runt-related ...
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2021-03-05ZeitschriftenartikelSARS-CoV-2-Varianten: Evolution im Zeitraffer Oh, Djin-Ye; Kröger, Stefan; Wedde, Marianne; Hartkopf, Felix; Budt, Matthias; Seifried, Janna; Radonic, Aleksandar; Belarbi, Essia; Hölzer, Martin; Böttcher, Sindy; Schubert, Grit; Kaiser, Sandra; Sachse, Andreas; Drechsel, Oliver; Grajcar, Romina; Huska, Matthew; Lanxin, Zhan; Domaszewska, Teresa; Zhang, Lanxin; Brinkmann, Annika; Yahosseini, Kyanoush; Grabenhenrich, Linus; Hamouda, Osamah; Dürrwald, Ralf; Haas, Walter; Calvignac-Spencer, Sébastien; Semmler, Torsten; Schaade, Lars; Mielke, Martin; von Kleist, Max; Fuchs, Stephan; Wieler, Lothar H.; Wolff, ThorstenDas Betacoronavirus SARS-CoV-2 gelangte höchstwahrscheinlich als zoonotischer Erreger gegen Ende 2019 in die menschliche Bevölkerung, vermutlich in Form einer einzelnen Transmission (monophyletischer Ursprung) aus einem ...
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2022-06-02ZeitschriftenartikelSynopse virologischer Analysen im Nationalen Referenzzentrum für Influenzaviren während der COVID-19-Pandemie Dürrwald, Ralf; Wedde, Marianne; Duwe, Susanne; Biere, Barbara; Reiche, Janine; Köndgen, Sophie; Ramos Calderón, Julia Patricia; Budt, Matthias; Drechsel, Oliver; Fuchs, Stephan; Haldemann, Berit; Hartkopf, Felix; Hölzer, Martin; Huska, Matthew; Kaiser, Sandra; Keeren, Kathrin; Kröger, Stefan; Paraskevopoulou, Sofia; Radonic, Aleksandar; Reinhardt, Bernd; Semmler, Torsten; Thürmer, Andrea; Trappe, Kathrin; Winter, Katja; Mielke, Martin; Buda, Silke; Oh, Djin-Ye; Wolff, ThorstenDas Nationale Referenzzentrum für Influenzaviren gewinnt durch die fortlaufende Untersuchung von Proben aus den Sentinelpraxen der Arbeitsgemeinschaft Influenza einen umfassenden Überblick über die zirkulierenden ...