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Browsing by Author "Hoffmann, Tobias"
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2021-01-17ZeitschriftenartikelBromelain inhibits SARS-CoV-2 infection via targeting ACE-2, TMPRSS2, and spike protein Sagar, Satish; Rathinavel, Ashok Kumar; Lutz, William E.; Struble, Lucas R.; Khurana, Surender; Schnaubelt, Andy T.; Mishra, Nitish Kumar; Guda, Chittibabu; Palermo, Nicholas Y.; Broadhurst, Mara J.; Hoffmann, Tobias; Bayles, Kenneth W.; Reid, St. Patrick M.; Borgstahl, Gloria E.O.; Radhakrishnan, PrakashThe new coronavirus, SARS-CoV-2, transmits rapidly from human-to-human resulting in the ongoing pandemic. SARS-CoV-2 infects angiotensin-converting enzyme 2 (ACE-2) expressing lung, heart, kidney, intestine, gall bladder, ...
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2022-03-04ZeitschriftenartikelIn vitro maturation of Toxoplasma gondii bradyzoites in human myotubes and their metabolomic characterization Christiansen, Céline; Maus, Deborah; Hoppenz, Ellen; Murillo-León, Mateo; Hoffmann, Tobias; Scholz, Jana; Melerowicz, Florian; Steinfeldt, Tobias; Seeber, Frank; Blume, MartinThe apicomplexan parasite Toxoplasma gondii forms bradyzoite-containing tissue cysts that cause chronic and drug-tolerant infections. However, current in vitro models do not allow long-term culture of these cysts to maturity. ...
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2021-02-10ZeitschriftenartikelMorphometry of SARS-CoV and SARS-CoV-2 particles in ultrathin plastic sections of infected Vero cell cultures Laue, Michael; Kauter, Anne; Hoffmann, Tobias; Möller, Lars; Michel, Janine; Nitsche, AndreasSARS-CoV-2 is the causative of the COVID-19 disease, which has spread pandemically around the globe within a few months. It is therefore necessary to collect fundamental information about the disease, its epidemiology and ...
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2023-02-06ZeitschriftenartikelVisualization of SARS-CoV-2 particles in naso/oropharyngeal swabs by thin section electron microscopy Laue, Michael; Hoffmann, Tobias; Michel, Janine; Nitsche, AndreasBackground SARS-CoV-2 replicates efficiently in the upper airways of humans and produces high loads of virus RNA and, at least in the initial phase after infection, many infectious virus particles. Studying virus ...