2016-12-01Zeitschriftenartikel
TLR7/8 agonist induces a post-entry SAMHD1-independent block to HIV-1 infection of monocytes
Hofmann, Henning; Vanwalscappel, Bénédicte; Bloch, Nicolin; Landau, Nathaniel R.
Background
Monocytes, the primary myeloid cell-type in peripheral blood, are resistant to HIV-1 infection as a result of the lentiviral restriction factor SAMHD1. Toll-like receptors recognize microbial pathogen components, ...
