2024-10-02Zeitschriftenartikel
MHC Hammer reveals genetic and non-genetic HLA disruption in cancer evolution
Puttick, Clare; Jones, Thomas P.; Leung, Michelle M.; Galvez-Cancino, Felipe; Liu, Jiali; Varas-Godoy, Manuel; Rowan, Andrew; Pich, Oriol; Martinez-Ruiz, Carlos; Bentham, Robert; Dijkstra, Krijn K.; Black, James R. M.; Rosenthal, Rachel; Kanu, Nnennaya; Litchfield, Kevin; Salgado, Roberto; Moore, David A.; Van Loo, Peter; Jamal-Hanjani, Mariam; Quezada, Sergio A.; TRACERx Consortium; Swanton, Charles; McGranahan, Nicholas
Disruption of the class I human leukocyte antigen (HLA) molecules has important implications for immune evasion and tumor evolution. We developed major histocompatibility complex loss of heterozygosity (LOH), allele-specific ...
