2013-05-30Zeitschriftenartikel
LEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions
Desimmie, Belete A.; Schrijvers, Rik; Demeulemeester, Jonas; Borrenberghs, Doortje; Weydert, Caroline; Thys, Wannes; Vets, Sofie; Remoortel, Barbara van; Hofkens, Johan; Rijck, Jan de; Hendrix, Jelle; Bannert, Norbert; Gijsbers, Rik; Christ, Frauke; Debyser, Zeger
Background: LEDGINs are novel allosteric HIV integrase (IN) inhibitors that target the lens epithelium-derived growth factor (LEDGF)/p75 binding pocket of IN. They block HIV-1 integration by abrogating the interaction ...