Auflistung nach Schlagwort "Cricetinae"
Anzeige der Publikationen 1-10 von 10
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2007-05-25ZeitschriftenartikelAccumulation of Pathological Prion Protein PrPSc in the Skin of Animals with Experimental and Natural Scrapie Prion infectivity and its molecular marker, the pathological prion protein PrPSc, accumulate in the central nervous system and often also in lymphoid tissue of animals or humans affected by transmissible spongiform ...
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2008-09-29ZeitschriftenartikelFaecal shedding, alimentary clearance and intestinal spread of prions in hamsters fed with scrapie Shedding of prions via faeces may be involved in the transmission of contagious prion diseases. Here, we fed hamsters 10mg of 263K scrapie brain homogenate and examined the faecal excretion of disease-associated prion ...
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2007-12-01ZeitschriftenartikelPrion propagation in a nerve conduit model containing segments devoid of axons Prions, the putative causative agents of transmissible spongiform encephalopathies, are neurotropic pathogens that spread to the central nervous system via synaptically linked neural conduits upon peripheral infection. ...
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2006-09-01ZeitschriftenartikelPropagation of scrapie in peripheral nerves after footpad infection in normal and neurotoxin exposed hamsters As is known from various animal models, the spread of agents causing transmissible spongiform encephalopathies (TSE) after peripheral infection affects peripheral nerves before reaching the central nervous system (CNS) ...
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2006-12-21ZeitschriftenartikelPropagation of scrapie in peripheral nerves after footpad infection in normal and neurotoxin exposed hamsters As is known from various animal models, the spread of agents causing transmissible spongiform encephalopathies (TSE) after peripheral infection affects peripheral nerves before reaching the central nervous system (CNS) and ...
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2011-05-27ZeitschriftenartikelQuantitative detection and biological propagation of scrapie seeding activity in vitro facilitate use of prions as model pathogens for disinfection. Prions are pathogens with an unusually high tolerance to inactivation and constitute a complex challenge to the re-processing of surgical instruments. On the other hand, however, they provide an informative paradigm which ...
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2007-09-25ZeitschriftenartikelRelevance of the regional lymph node in scrapie pathogenesis after peripheral infection of hamsters Background: The exact role of the lymphoreticular system in the spread of peripheral prion infections to the central nervous system still needs further elucidation. Against this background, the influence of the regional ...
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2007-05-09ZeitschriftenartikelScrapie Agent (Strain 263K) Can Transmit Disease via the Oral Route after Persistence in Soil over Years The persistence of infectious biomolecules in soil constitutes a substantial challenge. This holds particularly true with respect to prions, the causative agents of transmissible spongiform encephalopathies (TSEs) such as ...
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2013-06-05ZeitschriftenartikelSegmentation of Confocal Raman Microspectroscopic Imaging Data Using Edge-Preserving Denoising and Clustering Over the past decade, confocal Raman microspectroscopic (CRM) imaging has matured into a useful analytical tool to obtain spatially resolved chemical information on the molecular composition of biological samples and has ...
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2013-03-11ZeitschriftenartikelTowards further reduction and replacement of animal bioassays in prion research by cell and protein misfolding cyclic amplification assays Laboratory animals have long since been used extensively in bioassays for prions in order to quantify, usually in terms of median infective doses [ID50], how infectious these pathogens are in vivo. The identification of ...