2013-03-11Zeitschriftenartikel
Towards further reduction and replacement of animal bioassays in prion research by cell and protein misfolding cyclic amplification assays
Boerner, Susann; Wagenführ, Katja; Daus, Martin L.; Thomzig, Achim; Beekes, Michael
Laboratory animals have long since been used extensively in bioassays for prions in order to quantify, usually in terms of median infective doses [ID50], how infectious these pathogens are in vivo. The identification of ...