2011-05-31Zeitschriftenartikel
Improvement of H5N1 influenza vaccine viruses: Influence of internal gene segments of avian and human origin on production and hemagglutinin content
Abt, Marion; Jonge, Jørgen de; Laue, Michael; Wolff, Thorsten
The H5N1-clade 1 influenza vaccine strain NIBRG-14 produces exceptionally low amounts of antigen, a problem recently encountered also for initial pandemic H1N1-2009 vaccine seeds. Here, we report on a strategy that may ...