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2011-11-22Zeitschriftenartikel DOI: 10.1371/journal.pone.0028113
Ficolin-2 Levels and FCN2 Haplotypes Influence Hepatitis B Infection Outcome in Vietnamese Patients.
dc.contributor.authorTong, Hoang V.
dc.contributor.authorToan, Nguyen L.
dc.contributor.authorSong, Le H.
dc.contributor.authorOuf, Eman Abou
dc.contributor.authorBock, Thomas
dc.contributor.authorKremsner, Peter G.
dc.contributor.authorKun, Jürgen F. J.
dc.contributor.authorVelavan, T.P.
dc.date.accessioned2018-05-07T15:02:23Z
dc.date.available2018-05-07T15:02:23Z
dc.date.created2011-12-12
dc.date.issued2011-11-22none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/recG8syIBsG66/PDF/23cMZeEkhcjY.pdf
dc.identifier.urihttp://edoc.rki.de/176904/1016
dc.description.abstractHuman Ficolin-2 (L-ficolins) encoded by FCN2 gene is a soluble serum protein that plays an important role in innate immunity and is mainly expressed in the liver. Ficolin-2 serum levels and FCN2 single nucleotide polymorphisms were associated to several infectious diseases. We initially screened the complete FCN2 gene in 48 healthy individuals of Vietnamese ethnicity. We genotyped a Vietnamese cohort comprising of 423 clinically classified hepatitis B virus patients and 303 controls for functional single nucleotide polymorphisms in the promoter region (-986G>A, -602G>A, -4A>G) and in exon 8 (+6424G>T) by real-time PCR and investigated the contribution of FCN2 genotypes and haplotypes to serum Ficolin-2 levels, viral load and liver enzyme levels. Haplotypes differed significantly between patients and controls (P = 0.002) and the haplotype AGGG was found frequently in controls in comparison to patients with hepatitis B virus and hepatocellular carcinoma (P = 0.0002 and PA, +2363G>A, +4882G>A) and one synonymous mutation in exon 8 (+6485G>T) was observed. Strong linkage was found between the variant -986G>A and -4A>G. The very first study on Vietnamese cohort associates both Ficolin-2 serum levels and FCN2 haplotypes to hepatitis B virus infection and subsequent disease progression.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut
dc.subjectAdolescenteng
dc.subjectHumanseng
dc.subjectFemaleeng
dc.subjectMaleeng
dc.subjectMiddle Agedeng
dc.subjectAdulteng
dc.subjectCase-Control Studieseng
dc.subjectAgedeng
dc.subjectYoung Adulteng
dc.subjectHepatitis B/bloodeng
dc.subjectHaplotypes/geneticseng
dc.subjectGenetic Predisposition to Diseaseeng
dc.subjectHepatitis B/geneticseng
dc.subjectHepatitis B/virologyeng
dc.subjectHepatitis B virus/physiologyeng
dc.subjectLectins/bloodeng
dc.subjectLectins/geneticseng
dc.subjectLinkage Disequilibrium/geneticseng
dc.subjectPolymorphism Single Nucleotide/geneticseng
dc.subjectVietnameng
dc.subjectViral Load/geneticseng
dc.subject.ddc610 Medizin
dc.titleFicolin-2 Levels and FCN2 Haplotypes Influence Hepatitis B Infection Outcome in Vietnamese Patients.
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10017019
dc.identifier.doi10.1371/journal.pone.0028113
dc.identifier.doihttp://dx.doi.org/10.25646/941
local.edoc.container-titlePLoS ONE
local.edoc.container-textTong HV, Toan NL, Song LH, Ouf EA, Bock C-T, et al. (2011) Ficolin-2 Levels and FCN2 Haplotypes Influence Hepatitis B Infection Outcome in Vietnamese Patients. PLoS ONE 6(11): e28113.
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0028113
local.edoc.container-publisher-namePublic Library of Science
local.edoc.container-volume6
local.edoc.container-issue11
local.edoc.container-year2011

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