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2011-02-20Zeitschriftenartikel DOI: 10.1016/j.ejcb.2010.12.003
Characterisation of Legionella pneumophila phospholipases and their impact on host cells
dc.contributor.authorLang, Christina
dc.contributor.authorFlieger, Antje
dc.date.accessioned2018-05-07T15:22:06Z
dc.date.available2018-05-07T15:22:06Z
dc.date.created2012-02-21
dc.date.issued2011-02-20none
dc.identifier.otherhttp://edoc.rki.de/oa/articles/recNVhgSTVlvQ/PDF/22k9sJMkpiPZ6.pdf
dc.identifier.urihttp://edoc.rki.de/176904/1124
dc.description.abstractPhospholipases are a diverse class of enzymes produced both by eukaryotic hosts and their pathogens. Major insights into action pathways of bacterial phospholipases have been provided during the last years. On the one hand bacterial phospholipases act as potent membrane destructors and on the other hand they manipulate and initiate host signalling paths, such as chemokine expression or the inflammatory cascade. Reaction products of bacterial phospholipases may potentially influence many more host cell processes, such as cell respreading, lamellopodia formation, cell migration and membrane traffic. Phospholipases play a dominant role in the biology of the lung pathogen Legionella pneumophila. So far, 15 different phospholipase A-encoding genes have been identified in the L. pneumophila genome. These phospholipases can be divided into three major groups, the GDSL, the patatin-like and the PlaB-like enzymes. The first two lipase families are also found in higher plants (such as flowering plants) and the second family shows similarities to eukaryotic cytosolic phospholipases A. Therefore, when those enzymes are injected or secreted by the bacterium into the host cell they may mimic eukaryotic phospholipases. The current knowledge on L. pneumophila phospholipases is summarised here with emphasis on their activity, mode of secretion, localisation, expression and importance for host cell infections.eng
dc.language.isoeng
dc.publisherRobert Koch-Institut, Infektionskrankheiten / Erreger
dc.subjectBacteriaeng
dc.subjectLegionellaeng
dc.subjectPhospholipaseeng
dc.subjectFree fatty acidseng
dc.subjectLysophosphatidylcholineeng
dc.subjectInfectioneng
dc.subjectSignallingeng
dc.subject.ddc610 Medizin
dc.titleCharacterisation of Legionella pneumophila phospholipases and their impact on host cells
dc.typeperiodicalPart
dc.identifier.urnurn:nbn:de:0257-10019397
dc.identifier.doi10.1016/j.ejcb.2010.12.003
dc.identifier.doihttp://dx.doi.org/10.25646/1049
local.edoc.container-titleEuropean Journal of Cell Biology
local.edoc.container-textLang, C., Flieger, A. Characterisation of Legionella pneumophila phospholipases and their impact on host cells (2011) European Journal of Cell Biology, 90 (11), pp. 903-912.
local.edoc.fp-subtypeArtikel
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttp://www.sciencedirect.com/science/article/pii/S0171933510002694
local.edoc.container-publisher-nameElsevier
local.edoc.container-volume90
local.edoc.container-issue11
local.edoc.container-year2011

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