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2023-10-17Zeitschriftenartikel
Prevalence and risk factors for long COVID and post-COVID-19 condition in Africa: a systematic review
dc.contributor.authorMüller, Sophie Alice
dc.contributor.authorIsaaka, Lynda
dc.contributor.authorMumm, Rebekka
dc.contributor.authorScheidt-Nave, Christa
dc.contributor.authorHeldt, Katharina
dc.contributor.authorSchuster, Angela
dc.contributor.authorAbdulaziz, Mohammed
dc.contributor.authorEl Bcheraoui, Charbel
dc.contributor.authorHanefeld, Johanna
dc.contributor.authorAgweyu, Ambrose
dc.date.accessioned2023-11-14T13:37:27Z
dc.date.available2023-11-14T13:37:27Z
dc.date.issued2023-10-17none
dc.identifier.other10.1016/S2214-109X(23)00384-4
dc.identifier.urihttp://edoc.rki.de/176904/11344
dc.description.abstractSummary Background An improved estimation of the clinical sequelae of SARS-CoV-2 infection is crucial in African countries, where the subject has received little attention despite more than 12 million reported cases and evidence that many more people were infected. We reviewed the evidence on prevalence, associated risk factors for long COVID, and systemic or sociocultural determinants of reporting long COVID. Methods We conducted a systematic review, searching PubMed, the Living OVerview of Evidence platform, and grey literature sources for publications from Dec 1, 2019, to Nov 23, 2022. We included articles published in English, French, Spanish, or Portuguese that reported on any study type in Africa with participants of any age who had symptoms for 4 weeks or more after an acute SARS-CoV-2 infection. We excluded secondary research, comments, and correspondence. Screening and data extraction were performed by two reviewers. Summary estimates were extracted, including sociodemographic factors, medical history, prevalence of persistent symptoms, and symptoms and associated factors. Results were analysed descriptively. The study was registered on the Open Science Framework platform. Findings Our search yielded 294 articles, of which 24 peer-reviewed manuscripts were included, reporting on 9712 patients from eight African countries. Only one study exclusively recruited children, and one other study included children as part of their study population. Studies indicated moderate to low risk of bias. Prevalence of long COVID varied widely, from 2% in Ghana to 86% in Egypt. Long COVID was positively associated with female sex, older age, non-Black ethnicity, low level of education, and the severity of acute infection and underlying comorbidity. HIV and tuberculosis were not identified as risk factors. Factors influencing reporting included absence of awareness, inadequate clinical data and diagnostics, and little access to health-care services. Interpretation In Africa, research on long COVID is scarce, particularly among children, who represent the majority of the population. However, existing studies show a substantial prevalence across settings, emphasising the importance of vaccination and other prevention strategies to avert the effects of long COVID on individual wellbeing, the increased strain on health systems, and the potential negative effects on economically vulnerable populations. At a global level, including African countries, tools for research on long COVID need to be harmonised to maximise the usefulness of the data collected. Funding Noneeng
dc.language.isoundnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titlePrevalence and risk factors for long COVID and post-COVID-19 condition in Africa: a systematic reviewnone
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/11344-0
dc.type.versionpublishedVersionnone
local.edoc.container-titleThe Lancet Global Healthnone
local.edoc.container-issn2214-109Xnone
local.edoc.pages12none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.sciencedirect.com/journal/the-lancet-global-health/vol/11/issue/11none
local.edoc.container-publisher-nameElseviernone
local.edoc.container-volume11none
local.edoc.container-issue11none
local.edoc.container-reportyear2023none
local.edoc.container-firstpagee1713none
local.edoc.container-lastpagee1724none
dc.description.versionPeer Reviewednone

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