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2023-02-11Zeitschriftenartikel
Distinct tissue niches direct lung immunopathology via CCL18 and CCL21 in severe COVID-19
dc.contributor.authorMothes, Ronja
dc.contributor.authorPascual-Reguant, Anna
dc.contributor.authorKoehler, Ralf
dc.contributor.authorLiebeskind, Juliane
dc.contributor.authorLiebheit, Alina
dc.contributor.authorBauherr, Sandy
dc.contributor.authorPhilipsen, Lars
dc.contributor.authorDittmayer, Carsten
dc.contributor.authorLaue, Michael
dc.contributor.authorvon Manitius, Regina
dc.contributor.authorElezkurtaj, Sefer
dc.contributor.authorDurek, Pawel
dc.contributor.authorHeinrich, Frederik
dc.contributor.authorHeinz, Gitta A.
dc.contributor.authorGuerra, Gabriela M.
dc.contributor.authorObermayer, Benedikt
dc.contributor.authorMeinhardt, Jenny
dc.contributor.authorIhlow, Jana
dc.contributor.authorRadke, Josefine
dc.contributor.authorHeppner, Frank L.
dc.contributor.authorEnghard, Philipp
dc.contributor.authorStockmann, Helena
dc.contributor.authorAschman, Tom
dc.contributor.authorSchneider, Julia
dc.contributor.authorCorman, Victor M.
dc.contributor.authorSander, Leif E.
dc.contributor.authorMashreghi, Mir-Farzin
dc.contributor.authorConrad, Thomas
dc.contributor.authorHocke, Andreas C.
dc.contributor.authorNiesner, Raluca A.
dc.contributor.authorRadbruch, Helena
dc.contributor.authorHauser, Anja E.
dc.date.accessioned2023-11-17T16:47:58Z
dc.date.available2023-11-17T16:47:58Z
dc.date.issued2023-02-11none
dc.identifier.other10.1038/s41467-023-36333-2
dc.identifier.urihttp://edoc.rki.de/176904/11375
dc.description.abstractProlonged lung pathology has been associated with COVID-19, yet the cellular and molecular mechanisms behind this chronic inflammatory disease are poorly understood. In this study, we combine advanced imaging and spatial transcriptomics to shed light on the local immune response in severe COVID-19. We show that activated adventitial niches are crucial microenvironments contributing to the orchestration of prolonged lung immunopathology. Up-regulation of the chemokines CCL21 and CCL18 associates to endothelial-to-mesenchymal transition and tissue fibrosis within these niches. CCL21 over-expression additionally links to the local accumulation of T cells expressing the cognate receptor CCR7. These T cells are imprinted with an exhausted phenotype and form lymphoid aggregates that can organize in ectopic lymphoid structures. Our work proposes immune-stromal interaction mechanisms promoting a self-sustained and non-resolving local immune response that extends beyond active viral infection and perpetuates tissue remodeling.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectimmunopathogenesiseng
dc.subjectinfectioneng
dc.subjectSARS-CoV-2eng
dc.subjectviral infectioneng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleDistinct tissue niches direct lung immunopathology via CCL18 and CCL21 in severe COVID-19none
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/11375-8
dc.type.versionpublishedVersionnone
local.edoc.container-titleNature Communicationsnone
local.edoc.container-issn2041-1723none
local.edoc.pages16none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.nature.com/ncomms/none
local.edoc.container-publisher-nameSpringer Naturenone
local.edoc.container-volume14none
local.edoc.container-reportyear2023none
dc.description.versionPeer Reviewednone

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