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2020-05-11Zeitschriftenartikel
Spot urine iodine levels below the WHO recommendation are not related to impaired thyroid function in healthy children and adolescents
dc.contributor.authorWallborn, Tillmann
dc.contributor.authorVogel, Mandy
dc.contributor.authorKneuer, Antje
dc.contributor.authorThamm, Michael
dc.contributor.authorDittrich, Katalin
dc.contributor.authorKiess, Wieland
dc.contributor.authorKratzsch, Jürgen
dc.date.accessioned2023-12-12T10:55:36Z
dc.date.available2023-12-12T10:55:36Z
dc.date.issued2020-05-11none
dc.identifier.other10.1007/s00394-020-02268-3
dc.identifier.urihttp://edoc.rki.de/176904/11411
dc.description.abstractPurpose Iodine deficiency in childhood and adolescence may lead to later thyroid dysfunction, stunted growth and cognitive impairment. The World Health Organization (WHO) has issued recommended age-dependent urine iodine concentration targets, but a critical threshold beyond which clinical sequelae are to be expected remains undefined. Our study aimed to investigate spot urine iodine concentration in a typical Central European cohort of children and adolescents, and consider the implications of these values in regard to laboratory parameters for evaluating thyroid function. Methods Using the Sandell-Kolthoff method, spot urine iodine concentration was measured cross-sectionally from 1802 healthy children and adolescent in the age range of 0.25–18 years within the LIFE-Child epidemiological study based in and around the city of Leipzig (Germany). Additionally, serum thyroid biomarkers of these subjects were measured and correlated to urine iodine levels. Results In our cohort, 61.39% of boys and 65.91% of girls had an iodine level of < 100 µg/L (57%, 67%, 65% of the age groups 0–5, 6–12 and 13–18 years), the median iodine excretion was 86 µg/L in boys and 80 µg/L in girls. The iodine levels revealed no significant correlation with the thyroid biomarkers TSH, FT4 and FT3. Moreover, iodine values revealed no correlation with levels of antibodies against thyroid peroxidase or thyroglobulin. Conclusion In our cohort of children and adolescents, the relatively high number of iodine levels below the WHO recommendation appears not to be related to clinical or subclinical thyroid diseases in the respective participants.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectiodineeng
dc.subjectthyroideng
dc.subjecturineeng
dc.subjectchildreneng
dc.subjectTSHeng
dc.subjectFT4eng
dc.subjectFT3eng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleSpot urine iodine levels below the WHO recommendation are not related to impaired thyroid function in healthy children and adolescentsnone
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/11411-7
dc.type.versionpublishedVersionnone
local.edoc.container-titleEuropean Journal of Nutritionnone
local.edoc.container-issn1436-6215none
local.edoc.pages10none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://link.springer.com/journal/394none
local.edoc.container-publisher-nameSpringer Naturenone
local.edoc.container-volume60none
local.edoc.container-firstpage493none
local.edoc.container-lastpage502none
dc.description.versionPeer Reviewednone

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