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2020-09-12Zeitschriftenartikel
Designed Ankyrin Repeat Protein (DARPin) to target chimeric antigen receptor (CAR)-redirected T cells towards CD4+ T cells to reduce the latent HIV+ cell reservoir
dc.contributor.authorPatasic, Lea
dc.contributor.authorSeifried, Janna
dc.contributor.authorBezler, Valerie
dc.contributor.authorKaljanac, Marcell
dc.contributor.authorSchneider, Irene C.
dc.contributor.authorSchmitz, Heike
dc.contributor.authorTondera, Christiane
dc.contributor.authorHartmann, Jessica
dc.contributor.authorHombach, Andreas
dc.contributor.authorBuchholz, Christian J.
dc.contributor.authorAbken, Hinrich
dc.contributor.authorKönig, Renate
dc.contributor.authorCichutek, Klaus
dc.date.accessioned2024-01-04T15:42:43Z
dc.date.available2024-01-04T15:42:43Z
dc.date.issued2020-09-12none
dc.identifier.other10.1007/s00430-020-00692-0
dc.identifier.urihttp://edoc.rki.de/176904/11448
dc.description.abstractChimeric Antigen Receptor (CAR)-redirected T cells show great efficacy in the patient-specific therapy of hematologic malignancies. Here, we demonstrate that a DARPin with specificity for CD4 specifically redirects and triggers the activation of CAR engineered T cells resulting in the depletion of CD4+ target cells aiming for elimination of the human immunodeficiency virus (HIV) reservoir.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectDARPineng
dc.subjectCAR T Cellseng
dc.subjectHIV reservoireng
dc.subjectT cell therapyeng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleDesigned Ankyrin Repeat Protein (DARPin) to target chimeric antigen receptor (CAR)-redirected T cells towards CD4+ T cells to reduce the latent HIV+ cell reservoirnone
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/11448-3
dc.type.versionpublishedVersionnone
local.edoc.container-titleMedical Microbiology and Immunologynone
local.edoc.container-issn1432-1831none
local.edoc.pages11none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://link.springer.com/journal/430none
local.edoc.container-publisher-nameSpringer Naturenone
local.edoc.container-volume209none
local.edoc.container-reportyear2020none
local.edoc.container-firstpage681none
local.edoc.container-lastpage691none
dc.description.versionPeer Reviewednone

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