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2020-04-13Zeitschriftenartikel
Infectious KoRV-related retroviruses circulating in Australian bats
dc.contributor.authorHayward, Joshua A.
dc.contributor.authorTachedijan, Mary
dc.contributor.authorKohl, Claudia
dc.contributor.authorJohnson, Adam
dc.contributor.authorDearnley, Megan
dc.contributor.authorJesaveluk, Brianna
dc.contributor.authorLanger, Christine
dc.contributor.authorSolymosi, Philip D.
dc.contributor.authorHille, Georg
dc.contributor.authorNitsche, Andreas
dc.contributor.authorSánchez, Cecilia A.
dc.contributor.authorWerner, Adam
dc.contributor.authorKontos, Dimitri
dc.contributor.authorCrameri, Gary
dc.contributor.authorMarsh, Glenn A.
dc.contributor.authorPoumbourios, Pantelis
dc.contributor.authorDrummer, Heidi E.
dc.contributor.authorHolmes, Edward C.
dc.contributor.authorWang, Lin-Fa
dc.contributor.authorTachedijan, Gilda
dc.date.accessioned2024-02-05T16:50:41Z
dc.date.available2024-02-05T16:50:41Z
dc.date.issued2020-04-13none
dc.identifier.other10.1073/pnas.1915400117
dc.identifier.urihttp://edoc.rki.de/176904/11478
dc.description.abstractBats are reservoirs of emerging viruses that are highly pathogenic to other mammals, including humans. Despite the diversity and abundance of bat viruses, to date they have not been shown to harbor exogenous retroviruses. Here we report the discovery and characterization of a group of koala retrovirus-related (KoRV-related) gammaretroviruses in Australian and Asian bats. These include the Hervey pteropid gammaretrovirus (HPG), identified in the scat of the Australian black flying fox (Pteropus alecto), which is the first reproduction-competent retrovirus found in bats. HPG is a close relative of KoRV and the gibbon ape leukemia virus (GALV), with virion morphology and Mn2+-dependent virion-associated reverse transcriptase activity typical of a gammaretrovirus. In vitro, HPG is capable of infecting bat and human cells, but not mouse cells, and displays a similar pattern of cell tropism as KoRV-A and GALV. Population studies reveal the presence of HPG and KoRV-related sequences in several locations across northeast Australia, as well as serologic evidence for HPG in multiple pteropid bat species, while phylogenetic analysis places these bat viruses as the basal group within the KoRV-related retroviruses. Taken together, these results reveal bats to be important reservoirs of exogenous KoRV-related gammaretroviruses.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY-NC-ND 3.0 DE) Namensnennung - Nicht-kommerziell - Keine Bearbeitung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/de/
dc.subjectbatseng
dc.subjectviruseseng
dc.subjectretroviruseseng
dc.subjectKoRVeng
dc.subjectGALVeng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleInfectious KoRV-related retroviruses circulating in Australian batsnone
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/11478-7
dc.type.versionpublishedVersionnone
local.edoc.container-titleProceedings of the national academy of sciences of the united states of americanone
local.edoc.container-issn1091-6490none
local.edoc.pages8none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.pnas.org/none
local.edoc.container-publisher-nameNational Academy of Sciencesnone
local.edoc.container-volume117none
local.edoc.container-issue17none
local.edoc.container-reportyear2020none
local.edoc.container-firstpage9529none
local.edoc.container-lastpage9536none
dc.description.versionPeer Reviewednone

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