Show simple item record

2020-05-27Zeitschriftenartikel
A Recent Human Immunodeficiency Virus Outbreak Among People Who Inject Drugs in Munich, Germany, Is Associated With Consumption of Synthetic Cathinones
dc.contributor.authorHanke, Kirsten
dc.contributor.authorFiedler, Stefan
dc.contributor.authorGrumann, Christina
dc.contributor.authorRatmann, Oliver
dc.contributor.authorHauser, Andrea
dc.contributor.authorKlink, Patrycja
dc.contributor.authorMeixenberger, Karolin
dc.contributor.authorAltmann, Britta
dc.contributor.authorZimmermann, Ruth
dc.contributor.authorMarcus, Ulrich
dc.contributor.authorBremer, Viviane
dc.contributor.authorAuwärter, Volker
dc.contributor.authorBannert, Norbert
dc.date.accessioned2024-02-07T16:22:43Z
dc.date.available2024-02-07T16:22:43Z
dc.date.issued2020-05-27none
dc.identifier.other10.1093/ofid/ofaa192
dc.identifier.urihttp://edoc.rki.de/176904/11481
dc.description.abstractBackground. Needle and syringe sharing among people who inject drugs (PWID) can result in a rapid regional spread of a human immunodeficiency virus (HIV) variant. Such outbreaks have been identified recently in several countries and have raised public health attention because of an association with new psychoactive substances (NPS). Methods. Dried serum spots from approximately 60% of newly diagnosed HIV cases in Germany in 2013–2018 were received together with statutory notification data. Samples were sequenced in the pol-region, genotyped, and viral phylogenies were analyzed. For selected samples, the hepatitis C virus (HCV) status and the presence of NPS were determined. Results. An outbreak of closely related 27 subtype C infections with a core of 11 cases with almost identical sequences was identified using phylogenetic analyses. The first case of the outbreak was diagnosed in 2015, and the last one was in 2018. With exception of 3 infections, all were reported from Munich, the capital of the federal state of Bavaria. Of 26 analyzed outbreak members, 24 (92.3%) had a resolved or viremic HCV coinfection. In 8 of 18 (44%) cases, α-pyrrolidinopentiothiophenone and/or the related substance α-pyrrolidinoheptiophenone was identified. Conclusions. Despite harm reduction services in place, HIV outbreaks of considerable size can occur in PWID. The establishment of a real-time molecular surveillance is advised to rapidly identify outbreaks and target prevention measures.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY-NC-ND 3.0 DE) Namensnennung - Nicht-kommerziell - Keine Bearbeitung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/de/
dc.subjectdried serum spotseng
dc.subjectHIV-1 outbreakeng
dc.subjectnew psychoactive substanceseng
dc.subjectpeople who inject drugseng
dc.subjectsynthetic cathinoneseng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleA Recent Human Immunodeficiency Virus Outbreak Among People Who Inject Drugs in Munich, Germany, Is Associated With Consumption of Synthetic Cathinonesnone
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/11481-9
dc.type.versionupdatedVersionnone
local.edoc.container-titleOpen Forum Infectious Diseasesnone
local.edoc.container-issn2328-8957none
local.edoc.pages9none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://academic.oup.com/ofidnone
local.edoc.container-publisher-nameOxford University Pressnone
local.edoc.container-volume7none
local.edoc.container-issue6none
local.edoc.container-reportyear2020none
dc.description.versionPeer Reviewednone

Show simple item record