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2020-10-22Zeitschriftenartikel
Perspective on Proteomics for Virus Detection in Clinical Samples
dc.contributor.authorGrossegesse, Marica
dc.contributor.authorHartkopf, Felix
dc.contributor.authorNitsche, Andreas
dc.contributor.authorSchaade, Lars
dc.contributor.authorDoellinger, Joerg
dc.contributor.authorMuth, Thilo
dc.date.accessioned2024-02-07T16:52:39Z
dc.date.available2024-02-07T16:52:39Z
dc.date.issued2020-10-22none
dc.identifier.other10.1021/acs.jproteome.0c00674
dc.identifier.urihttp://edoc.rki.de/176904/11484
dc.description.abstractOne of the most widely used methods to detect an acute viral infection in clinical specimens is diagnostic real-time polymerase chain reaction. However, because of the COVID-19 pandemic, mass-spectrometry-based proteomics is currently being discussed as a potential diagnostic method for viral infections. Because proteomics is not yet applied in routine virus diagnostics, here we discuss its potential to detect viral infections. Apart from theoretical considerations, the current status and technical limitations are considered. Finally, the challenges that have to be overcome to establish proteomics in routine virus diagnostics are highlighted.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.subjectvirus proteomicseng
dc.subjectmass spectrometryeng
dc.subjectvirus diagnosticseng
dc.subjectCOVID-19eng
dc.subjectSARS-CoV-2eng
dc.subjecttargeted proteomicseng
dc.subjecttargeted mass spectrometryeng
dc.subjectpeptide selectioneng
dc.subjectparallel reaction monitoringeng
dc.subjectPRMeng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titlePerspective on Proteomics for Virus Detection in Clinical Samplesnone
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/11484-3
dc.type.versionpublishedVersionnone
local.edoc.container-titleJournal of Proteome Researchnone
local.edoc.container-issn1535-3907none
local.edoc.pages9none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://pubs.acs.org/journal/jprobsnone
local.edoc.container-publisher-nameACS Publicationsnone
local.edoc.container-volume19none
local.edoc.container-issue11none
local.edoc.container-reportyear2020none
local.edoc.container-firstpage4380none
local.edoc.container-lastpage4388none
dc.description.versionPeer Reviewednone

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