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2021-03-21Zeitschriftenartikel
The Spatiotemporal Dynamics and Microevolution Events That Favored the Success of the Highly Clonal Multidrug-Resistant Monophasic Salmonella Typhimurium Circulating in Europe
dc.contributor.authorCadel-Six, Sabrina
dc.contributor.authorCherchame, Emeline
dc.contributor.authorDouarre, Pierre-Emmanuel
dc.contributor.authorTang, Yue
dc.contributor.authorFelten, Arnaud
dc.contributor.authorBarbet, Pauline
dc.contributor.authorLitrup, Eva
dc.contributor.authorBanerji, Sangeeta
dc.contributor.authorSimon, Sandra
dc.contributor.authorPasquali, Frederique
dc.contributor.authorGourmelon, Michèle
dc.contributor.authorMensah, Nana
dc.contributor.authorBorowiak, Maria
dc.contributor.authorMistou, Michel-Yves
dc.contributor.authorPetrovska, Liljana
dc.date.accessioned2024-06-05T14:31:56Z
dc.date.available2024-06-05T14:31:56Z
dc.date.issued2021-03-21none
dc.identifier.other10.3389/fmicb.2021.651124
dc.identifier.urihttp://edoc.rki.de/176904/11686
dc.description.abstractThe European epidemic monophasic variant of Salmonella enterica serovar Typhimurium (S. 1,4,[5],12:i:-) characterized by the multi locus sequence type ST34 and the antimicrobial resistance ASSuT profile has become one of the most common serovars in Europe (EU) and the United States (US). In this study, we reconstructed the time-scaled phylogeny and evolution of this Salmonella in Europe. The epidemic S. 1,4,[5],12:i:- ST34 emerged in the 1980s by an acquisition of the Salmonella Genomic Island (SGI)-4 at the 3′ end of the phenylalanine phe tRNA locus conferring resistance to copper and arsenic toxicity. Subsequent integration of the Tn21 transposon into the fljAB locus gave resistance to mercury toxicity and several classes of antibiotics used in food-producing animals (ASSuT profile). The second step of the evolution occurred in the 1990s, with the integration of mTmV and mTmV-like prophages carrying the perC and/or sopE genes involved in the ability to reduce nitrates in intestinal contents and facilitate the disruption of the junctions of the host intestinal epithelial cells. Heavy metals are largely used as food supplements or pesticide for cultivation of seeds intended for animal feed so the expansion of the epidemic S. 1,4,[5],12:i:- ST34 was strongly related to the multiple-heavy metal resistance acquired by transposons, integrative and conjugative elements and facilitated by the escape until 2011 from the regulatory actions applied in the control of S. Typhimurium in Europe. The genomic plasticity of the epidemic S. 1,4,[5],12:i:- was demonstrated in our study by the analysis of the plasmidome. We were able to identify plasmids harboring genes mediating resistance to phenicols, colistin, and fluoroquinolone and also describe for the first time in six of the analyzed genomes the presence of two plasmids (pERR1744967-1 and pERR2174855-2) previously described only in strains of enterotoxigenic Escherichia coli and E. fergusonii.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectepidemic monophasic typhimuriumeng
dc.subjectcore and accessory genome phylogenetic analysiseng
dc.subjectbayesian analysiseng
dc.subjectplasmidomeeng
dc.subjectresistomeeng
dc.subjectmicroevolution european studyeng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleThe Spatiotemporal Dynamics and Microevolution Events That Favored the Success of the Highly Clonal Multidrug-Resistant Monophasic Salmonella Typhimurium Circulating in Europenone
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/11686-1
dc.type.versionpublishedVersionnone
local.edoc.container-titleFrontiers in Microbiologynone
local.edoc.container-issn1664-302Xnone
local.edoc.pages16none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.frontiersin.org/journals/microbiologynone
local.edoc.container-publisher-nameFrontiers Meadia S.A.none
local.edoc.container-volume12none
local.edoc.container-reportyear2021none
dc.description.versionPeer Reviewednone

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