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2021-11-13Zeitschriftenartikel
Evaluation of virulence potential of methicillin-sensitive and methicillin-resistant Staphylococcus aureus isolates from a German refugee cohort
dc.contributor.authorGreutz, Ines
dc.contributor.authorBusche, Tobias
dc.contributor.authorLayer, Franziska
dc.contributor.authorBednarz, Hanna
dc.contributor.authorKalinowski, Jörn
dc.contributor.authorNiehaus, Karsten
dc.date.accessioned2024-06-05T14:57:26Z
dc.date.available2024-06-05T14:57:26Z
dc.date.issued2021-11-13none
dc.identifier.other10.1016/j.tmaid.2021.102204
dc.identifier.urihttp://edoc.rki.de/176904/11688
dc.description.abstractBackground Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) seem to be highly transmissible, often infect otherwise healthy humans and frequently occur in hospital outbreaks. Methods Refugees, living in accommodations in Germany were screened for nasal carriage of S. aureus. The isolates were investigated regarding resistance and virulence, phenotypically and by whole genome data analysis. Results 5.6% (9/161) of the refugees are carriers of S. aureus. 2.5% (4/161) are MRSA carriers. Among the refugees, spa-types t021, t084, t304, t991 and t4983 were detected, as well as the new spa-types t18794 and t18795. t304 and t991 are assumed to be local spa-types from the middle east. The isolates are less resistant and marginal biofilm formers. Each isolate has a remarkable set of virulence genes, although genes, encoding for proteins strongly associated with invasive S. aureus infections, like Panton-Valentine leucocidin, were not detected. Conclusion The detection of strains from the middle east, supports the assumption that strains co-travel with the refugees and persist despite a transition of the host's living conditions. Whole genome data analysis does not permit to finally evaluate a germ's virulence. Nevertheless, an impression of the virulence potential of the strains, regarding skills in colonization, resistance, immune evasion, and host cell damaging can be pictured.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY-NC-ND 3.0 DE) Namensnennung - Nicht-kommerziell - Keine Bearbeitung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/de/
dc.subjectcommunity-acquiredeng
dc.subjectMRSAeng
dc.subjectMSSAeng
dc.subjectasylum seekereng
dc.subjectwhole genome sequencingeng
dc.subjectasymptomatic carriageeng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleEvaluation of virulence potential of methicillin-sensitive and methicillin-resistant Staphylococcus aureus isolates from a German refugee cohortnone
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/11688-0
dc.type.versionpublishedVersionnone
local.edoc.container-titleTravel Medicine and Infectious Diseasenone
local.edoc.container-issn1873-0442none
local.edoc.pages14none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.sciencedirect.com/journal/travel-medicine-and-infectious-diseasenone
local.edoc.container-publisher-nameElseviernone
local.edoc.container-volume45none
local.edoc.container-reportyear2021none

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