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2021-06-22Zeitschriftenartikel
Structure of Chimpanzee Gut Microbiomes across Tropical Africa
dc.contributor.authorBueno de Mesquita, Clifton P.
dc.contributor.authorNichols, Lauren M.
dc.contributor.authorGebert, Matthew J.
dc.contributor.authorVanderburgh, Caihong
dc.contributor.authorBocksberger, Gaëlle
dc.contributor.authorLester, Jack D.
dc.contributor.authorKalan, Ammie K.
dc.contributor.authorDieeguez, Paula
dc.contributor.authorMcCarthy, Maureen S.
dc.contributor.authorAgbor, Anthony
dc.contributor.authorÁlvarez Varona, Paula
dc.contributor.authorAyimisin, Ayuk Emmanuel
dc.contributor.authorBessone, Mattia
dc.contributor.authorChancellor, Rebecca
dc.contributor.authorCohen, Heather
dc.contributor.authorCoupland, Charlotte
dc.contributor.authorDeschner, Tobias
dc.contributor.authorEgbe, Villard Ebot
dc.contributor.authorGoedmakers, Annemarie
dc.contributor.authorGranjon, Anne-Céline
dc.contributor.authorGrueter, Cyril C.
dc.contributor.authorHead, Josephine
dc.contributor.authorHernandez-Aguilar, R. Adriana
dc.contributor.authorJeffrey, Kathryn J.
dc.contributor.authorJones, Sorrel
dc.contributor.authorKadam, Parag
dc.contributor.authorKaiser, Michael
dc.contributor.authorLapuente, Juan
dc.contributor.authorLarson, Bradley
dc.contributor.authorMarrocoli, Sergio
dc.contributor.authorMorgan, David
dc.contributor.authorMugerwa, Badru
dc.contributor.authorMulindahabi, Felix
dc.contributor.authorNeil, Emily
dc.contributor.authorNiyigaba, Protais
dc.contributor.authorPacheco, Liliana
dc.contributor.authorPiel, Allex K.
dc.contributor.authorRobbins, Martha M.
dc.contributor.authorRundus, Aaron
dc.contributor.authorSanz, Crickette M.
dc.contributor.authorSciaky, Lilah
dc.contributor.authorSheil, Douglas
dc.contributor.authorSommer, Volker
dc.contributor.authorStewart, Fiona A.
dc.contributor.authorTon, Els
dc.contributor.authorvan Schijndel, Joost
dc.contributor.authorVergnes, Virginie
dc.contributor.authorWessling, Erin G.
dc.contributor.authorWittig, Roman M.
dc.contributor.authorYuh, Yisa Ginath
dc.contributor.authorYurkiw, Kyle
dc.contributor.authorZuberbühler, Klaus
dc.contributor.authorGorgarten, Jan F.
dc.contributor.authorHeintz-Buschart, Anna
dc.contributor.authorMuellner-Riehl, Alexandra N.
dc.contributor.authorBoesch, Cristophe
dc.contributor.authorKühl, Hjalmar S.
dc.contributor.authorFierer, Noah
dc.contributor.authorArandjelovic, Mimi
dc.contributor.authorDunn, Robert R.
dc.date.accessioned2024-06-10T10:58:05Z
dc.date.available2024-06-10T10:58:05Z
dc.date.issued2021-06-22none
dc.identifier.other10.1128/msystems.01269-20
dc.identifier.urihttp://edoc.rki.de/176904/11695
dc.description.abstractUnderstanding variation in host-associated microbial communities is important given the relevance of microbiomes to host physiology and health. Using 560 fecal samples collected from wild chimpanzees (Pan troglodytes) across their range, we assessed how geography, genetics, climate, vegetation, and diet relate to gut microbial community structure (prokaryotes, eukaryotic parasites) at multiple spatial scales. We observed a high degree of regional specificity in the microbiome composition, which was associated with host genetics, available plant foods, and potentially with cultural differences in tool use, which affect diet. Genetic differences drove community composition at large scales, while vegetation and potentially tool use drove within-region differences, likely due to their influence on diet. Unlike industrialized human populations in the United States, where regional differences in the gut microbiome are undetectable, chimpanzee gut microbiomes are far more variable across space, suggesting that technological developments have decoupled humans from their local environments, obscuring regional differences that could have been important during human evolution. IMPORTANCE Gut microbial communities are drivers of primate physiology and health, but the factors that influence the gut microbiome in wild primate populations remain largely undetermined. We report data from a continent-wide survey of wild chimpanzee gut microbiota and highlight the effects of genetics, vegetation, and potentially even tool use at different spatial scales on the chimpanzee gut microbiome, including bacteria, archaea, and eukaryotic parasites. Microbial community dissimilarity was strongly correlated with chimpanzee population genetic dissimilarity, and vegetation composition and consumption of algae, honey, nuts, and termites were potentially associated with additional divergence in microbial communities between sampling sites. Our results suggest that host genetics, geography, and climate play a far stronger role in structuring the gut microbiome in chimpanzees than in humans.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectprokaryoteseng
dc.subjectparasiteseng
dc.subjectdieteng
dc.subjecttoolseng
dc.subjecthost geneticseng
dc.subjectclimateeng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleStructure of Chimpanzee Gut Microbiomes across Tropical Africanone
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/11695-0
dc.type.versionpublishedVersionnone
local.edoc.container-titlemSystemsnone
local.edoc.container-issn2379-5077none
local.edoc.pages20none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://journals.asm.org/journal/msystemsnone
local.edoc.container-publisher-nameAmerican Society for Microbiologynone
local.edoc.container-volume6none
local.edoc.container-issue3none
local.edoc.container-reportyear2021none
dc.description.versionPeer Reviewednone

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