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2021-05Zeitschriftenartikel
Active Case Finding of Current Bornavirus Infections in Human Encephalitis Cases of Unknown Etiology, Germany, 2018–2020
dc.contributor.authorEisermann, Philip
dc.contributor.authorRubbenstroth, Dennis
dc.contributor.authorCadar, Daniel
dc.contributor.authorThomé-Bolduan, Corinna
dc.contributor.authorEggert, Petra
dc.contributor.authorSchlaphof, Alexander
dc.contributor.authorLeypoldt, Frank
dc.contributor.authorStangel, Martin
dc.contributor.authorFortwängler, Thorsten
dc.contributor.authorHoffmann, Florian
dc.contributor.authorOstermann, Andreas
dc.contributor.authorZange, Sabine
dc.contributor.authorNiller, Hans-Helmut
dc.contributor.authorAngstwurm, Klemens
dc.contributor.authorPörtner, Kirsten
dc.contributor.authorFrank, Christina
dc.contributor.authorWilking, Hendrik
dc.contributor.authorBeer, Martin
dc.contributor.authorSchmidt-Chanasit, Jonas
dc.contributor.authorTappe, Dennis
dc.date.accessioned2024-06-10T11:59:47Z
dc.date.available2024-06-10T11:59:47Z
dc.date.issued2021-05none
dc.identifier.other10.3201/eid2705.204490
dc.identifier.urihttp://edoc.rki.de/176904/11700
dc.description.abstractHuman bornavirus encephalitis is a severe and often fatal infection caused by variegated squirrel bornavirus 1 (VSBV-1) and Borna disease virus 1 (BoDV-1). We conducted a prospective study of bornavirus etiology of encephalitis cases in Germany during 2018–2020 by using a serologic testing scheme applied along proposed graded case definitions for VSBV-1, BoDV-1, and unspecified bornavirus encephalitis. Of 103 encephalitis cases of unknown etiology, 4 bornavirus infections were detected serologically. One chronic case was caused by VSBV-1 after occupational-related contact of a person with exotic squirrels, and 3 acute cases were caused by BoDV-1 in virus-endemic areas. All 4 case-patients died. Bornavirus etiology could be confirmed by molecular methods. Serologic testing for these cases was virus specific, discriminatory, and a practical diagnostic option for living patients if no brain tissue samples are available. This testing should be guided by clinical and epidemiologic suspicions, such as residence in virus-endemic areas and animal exposure.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleActive Case Finding of Current Bornavirus Infections in Human Encephalitis Cases of Unknown Etiology, Germany, 2018–2020none
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/11700-1
dc.type.versionpublishedVersionnone
local.edoc.container-titleEmerging Infectious Diseasesnone
local.edoc.container-issn1080-6059none
local.edoc.pages9none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://wwwnc.cdc.gov/eid/none
local.edoc.container-publisher-nameCenters for Disease Control and Preventionnone
local.edoc.container-volume27none
local.edoc.container-issue5none
local.edoc.container-reportyear2021none

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