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2021-02-22Zeitschriftenartikel
Predominance of HBV Genotype B and HDV Genotype 1 in Vietnamese Patients with Chronic Hepatitis
dc.contributor.authorXuan Hoan, Nghiem
dc.contributor.authorHoechel, Mirjam
dc.contributor.authorTomazatos, Alexandru
dc.contributor.authorXuan Anh, Chu
dc.contributor.authorreddy Pallerla, Srinivas
dc.contributor.authorThi Kieu Linh, Le
dc.contributor.authorThanh Binh, Mai
dc.contributor.authorBui Tien, Sy
dc.contributor.authorNguyen Linh, Toan
dc.contributor.authorWedemeyer, Heiner
dc.contributor.authorBock, Claus-Thomas
dc.contributor.authorKremsner, Peter G.
dc.contributor.authorHuu Song, Le
dc.contributor.authorVelavan, Thirumalaisamy P.
dc.date.accessioned2024-06-12T16:38:23Z
dc.date.available2024-06-12T16:38:23Z
dc.date.issued2021-02-22none
dc.identifier.other10.3390/v13020346
dc.identifier.urihttp://edoc.rki.de/176904/11719
dc.description.abstractHepatitis delta virus (HDV) coinfection will additionally aggravate the hepatitis B virus (HBV) burden in the coming decades, with an increase in HBV-related liver diseases. Between 2018 and 2019, a total of 205 HBV patients clinically characterized as chronic hepatitis B (CHB; n = 115), liver cirrhosis (LC; n = 21), and hepatocellular carcinoma (HCC; n = 69) were recruited. HBV surface antigen (HBsAg), antibodies against surface antigens (anti-HBs), and core antigens (anti-HBc) were determined by ELISA. The presence of hepatitis B viral DNA and hepatitis delta RNA was determined. Distinct HBV and HDV genotypes were phylogenetically reconstructed and vaccine escape mutations in the “a” determinant region of HBV were elucidated. All HBV patients were HbsAg positive, with 99% (n = 204) and 7% (n = 15) of them being positive for anti-HBc and anti-HBs, respectively. Anti-HBs positivity was higher among HCC (15%; n = 9) compared to CHB patients. The HBV-B genotype was predominant (65%; n = 134), followed by HBV-C (31%; n = 64), HBV-D, and HBV-G (3%; n = 7). HCC was observed frequently among young individuals with HBV-C genotypes. A low frequency (2%; n = 4) of vaccine escape mutations was observed. HBV-HDV coinfection was observed in 16% (n = 33) of patients with the predominant occurrence of the HDV-1 genotype. A significant association of genotypes with alanine aminotransferase (ALT) and aspartate aminotransferase (AST) enzyme levels was observed in HBV monoinfections. The prevalence of the HDV-1 genotype is high in Vietnam. No correlation was observed between HDV-HBV coinfections and disease progression when compared to HBV monoinfectionseng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjecthepatitis D viruseng
dc.subjecthepatitis B viruseng
dc.subjectgenotypeseng
dc.subjectVietnameng
dc.subjecthepatocellular carcinomaeng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titlePredominance of HBV Genotype B and HDV Genotype 1 in Vietnamese Patients with Chronic Hepatitisnone
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/11719-6
dc.type.versionpublishedVersionnone
local.edoc.container-titlevirusesnone
local.edoc.container-issn1999-4915none
local.edoc.pages12none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.mdpi.com/journal/virusesnone
local.edoc.container-publisher-nameMDPInone
local.edoc.container-volume13none
local.edoc.container-issue2none
local.edoc.container-reportyear2021none
dc.description.versionPeer Reviewednone

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