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2021-12-21Zeitschriftenartikel
Brain connectivity inversely scales with developmental temperature in Drosophila
dc.contributor.authorKiral, Ferdi Ridvan
dc.contributor.authorDutta, Suchetana B.
dc.contributor.authorLinneweber, Gerit Arne
dc.contributor.authorHilgert, Selina
dc.contributor.authorPoppa, Caroline
dc.contributor.authorDuch, Carsten
dc.contributor.authorvon Kleist, Max
dc.contributor.authorHassan, Bassem A.
dc.contributor.authorHiesinger, P. Robin
dc.date.accessioned2024-07-09T13:11:33Z
dc.date.available2024-07-09T13:11:33Z
dc.date.issued2021-12-21none
dc.identifier.other10.1016/j.celrep.2021.110145
dc.identifier.urihttp://edoc.rki.de/176904/11767
dc.description.abstractVariability of synapse numbers and partners despite identical genes reveals the limits of genetic determinism. Here, we use developmental temperature as a non-genetic perturbation to study variability of brain wiring and behavior in Drosophila. Unexpectedly, slower development at lower temperatures increases axo-dendritic branching, synapse numbers, and non-canonical synaptic partnerships of various neurons, while maintaining robust ratios of canonical synapses. Using R7 photoreceptors as a model, we show that changing the relative availability of synaptic partners using a DIPγ mutant that ablates R7’s preferred partner leads to temperature-dependent recruitment of non-canonical partners to reach normal synapse numbers. Hence, R7 synaptic specificity is not absolute but based on the relative availability of postsynaptic partners and presynaptic control of synapse numbers. Behaviorally, movement precision is temperature robust, while movement activity is optimized for the developmentally encountered temperature. These findings suggest genetically encoded relative and scalable synapse formation to develop functional, but not identical, brains and behaviors.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY-NC-ND 3.0 DE) Namensnennung - Nicht-kommerziell - Keine Bearbeitung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/de/
dc.subjectDrosophilaeng
dc.subjectbrain wiringeng
dc.subjectneuronal connectivityeng
dc.subjecttemperatureeng
dc.subjectsynaptic specificityeng
dc.subjectbrain developmenteng
dc.subjectbranchingeng
dc.subjectfilopodiaeng
dc.subjectvariabilityeng
dc.subjectbehavioreng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleBrain connectivity inversely scales with developmental temperature in Drosophilanone
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/11767-1
dc.type.versionpublishedVersionnone
local.edoc.container-titleCell Reportsnone
local.edoc.container-issn2211-1247none
local.edoc.pages25none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.sciencedirect.com/journal/cell-reportsnone
local.edoc.container-publisher-nameElseviernone
local.edoc.container-volume37none
local.edoc.container-issue12none
local.edoc.container-reportyear2021none
dc.description.versionPeer Reviewednone

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