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2021-12-25Zeitschriftenartikel
SARS-CoV-2 Aerosol Transmission Indoors: A Closer Look at Viral Load, Infectivity, the Effectiveness of Preventive Measures and a Simple Approach for Practical Recommendations
dc.contributor.authorKriegel, Martin
dc.contributor.authorHartmann, Anne
dc.contributor.authorBuchholz, Udo
dc.contributor.authorSeifried, Janna
dc.contributor.authorBaumgarte, Sigrid
dc.contributor.authorGastmeier, Petra
dc.date.accessioned2024-07-09T16:34:59Z
dc.date.available2024-07-09T16:34:59Z
dc.date.issued2021-12-25none
dc.identifier.other10.3390/ijerph19010220
dc.identifier.urihttp://edoc.rki.de/176904/11771
dc.description.abstractThere is uncertainty about the viral loads of infectious individuals required to transmit COVID-19 via aerosol. In addition, there is a lack of both quantification of the influencing parameters on airborne transmission and simple-to-use models for assessing the risk of infection in practice, which furthermore quantify the influence of non-medical preventive measures. In this study, a dose–response model was adopted to analyze 25 documented outbreaks at infection rates of 4–100%. We show that infection was only possible if the viral load was higher than 108 viral copies/mL. Based on mathematical simplifications of our approach to predict the probable situational attack rate (PARs) of a group of persons in a room, and valid assumptions, we provide simplified equations to calculate, among others, the maximum possible number of persons and the person-related virus-free air supply flow necessary to keep the number of newly infected persons to less than one. A comparison of different preventive measures revealed that testing contributes the most to the joint protective effect, besides wearing masks and increasing ventilation. In addition, we conclude that absolute volume flow rate or person-related volume flow rate are more intuitive parameters for evaluating ventilation for infection prevention than air exchange rate.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectairborne transmissioneng
dc.subjectinfection preventioneng
dc.subjectrisk assessment modeleng
dc.subjectsimplified approacheseng
dc.subjectSARS-CoV-2eng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleSARS-CoV-2 Aerosol Transmission Indoors: A Closer Look at Viral Load, Infectivity, the Effectiveness of Preventive Measures and a Simple Approach for Practical Recommendationsnone
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/11771-8
dc.type.versionpublishedVersionnone
local.edoc.container-titleInternational Journal of Environmental Research and Public Healthnone
local.edoc.container-issn1660-4601none
local.edoc.pages31none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.mdpi.com/journal/ijerphnone
local.edoc.container-publisher-nameMDPInone
local.edoc.container-volume19none
local.edoc.container-issue1none
local.edoc.container-reportyear2021none
dc.description.versionPeer Reviewednone

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