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2021-05-21Zeitschriftenartikel
Phylogenetic Tracking of LA-MRSA ST398 Intra-Farm Transmission among Animals, Humans and the Environment on German Dairy Farms
dc.contributor.authorLienen, Tobias
dc.contributor.authorSchnitt, Arne
dc.contributor.authorCuny, Christiane
dc.contributor.authorMaurischt, Sven
dc.contributor.authorTenhagen, Bernd-Alois
dc.date.accessioned2024-07-10T10:21:32Z
dc.date.available2024-07-10T10:21:32Z
dc.date.issued2021-05-21none
dc.identifier.other10.3390/microorganisms9061119
dc.identifier.urihttp://edoc.rki.de/176904/11780
dc.description.abstractMethicillin-resistant Staphylococcus aureus (MRSA) are a major threat to human and animal health, causing difficult-to-treat infections. The aim of our study was to evaluate the intra-farm transmission of livestock-associated (LA) MRSA sequence type (ST) 398 isolates on German dairy farms. A total of 115 LA-MRSA ST398 isolates originating from animals, humans and the environment of six dairy farms were analyzed by whole-genome sequencing and core genome multilocus sequence typing. Phylogenetic clusters of high allelic similarity were detected on all dairy farms, suggesting a MRSA transmission across the different niches. On one farm, closely related isolates from quarter milk samples (QMS), suckers of calf feeders and nasal cavities of calves indicate that MRSA may be transferred by feeding contaminated milk to calves. Detection of related MRSA isolates in QMS and teat cups (4/6 farms) or QMS and human samples (3/4 farms) pointed out a transmission of MRSA between cows during the milking process and a potential zoonotic risk. In conclusion, LA-MRSA ST398 isolates may spread between animals, humans and the environment on dairy farms. Milking time hygiene and other internal biosecurity measures on farms and pre-treatment of milk before feeding it to calves may reduce the risk of MRSA transmission.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectLA-MRSAeng
dc.subjectdairy farmseng
dc.subjectintra-farm transmissioneng
dc.subjectphylogenomicseng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titlePhylogenetic Tracking of LA-MRSA ST398 Intra-Farm Transmission among Animals, Humans and the Environment on German Dairy Farmsnone
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/11780-7
dc.type.versionpublishedVersionnone
local.edoc.container-titleMicroorganismsnone
local.edoc.container-issn2076-2607none
local.edoc.pages9none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.mdpi.com/journal/microorganismsnone
local.edoc.container-publisher-nameMDPInone
local.edoc.container-volume9none
local.edoc.container-issue6none
local.edoc.container-reportyear2021none
dc.description.versionPeer Reviewednone

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