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2021-03-05Zeitschriftenartikel
High Prevalence of Carbapenemase-Producing Acinetobacter baumannii in Wound Infections, Ghana, 2017/2018
dc.contributor.authorMonnheimer, Mathieu
dc.contributor.authorCooper, Paul
dc.contributor.authorAmegbletor, Harold K.
dc.contributor.authorPellio, Theresia
dc.contributor.authorGroß, Uwe
dc.contributor.authorPfeifer, Yvonne
dc.contributor.authorSchulze, Marco H.
dc.date.accessioned2024-07-17T12:55:27Z
dc.date.available2024-07-17T12:55:27Z
dc.date.issued2021-03-05none
dc.identifier.other10.3390/microorganisms9030537
dc.identifier.urihttp://edoc.rki.de/176904/11795
dc.description.abstractThree years after a prospective study on wound infections in a rural hospital in Ghana revealed no emergence of carbapenem-resistant bacteria we initiated a new study to assess the prevalence of multidrug-resistant pathogens. Three hundred and one samples of patients with wound infections were analysed for the presence of resistant bacteria in the period August 2017 till March 2018. Carbapenem-resistant Acinetobacter (A.) baumannii were further characterized by resistance gene sequencing, PCR-based bacterial strain typing, pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST “Oxford scheme”). A. baumanni was detected in wound infections of 45 patients (15%); 22 isolates were carbapenem-resistant. Carbapenemases NDM-1 and/or OXA-23 were detected in all isolates; two isolates harboured additionally OXA-420. PFGE and MLST analyses confirmed the presence of one A. baumannii strain in 17 patients that was assigned to the worldwide spread sequence type ST231 and carried NDM-1 and OXA-23. Furthermore, two new A. baumannii STs (ST2145 and ST2146) were detected in two and three patients, respectively. Within three years the prevalence of carbapenem-resistant A. baumannii increased dramatically in the hospital. The early detection of multidrug-resistant bacteria and prevention of their further spread are only possible if continuous surveillance and molecular typing will be implemented.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subjectacinetobacter baumanniieng
dc.subjectcarbapenem resistanceeng
dc.subjectOXA-23eng
dc.subjectOXA-420eng
dc.subjectNDM-1eng
dc.subjectwound infectionseng
dc.subjectGhanaeng
dc.subjectruraleng
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleHigh Prevalence of Carbapenemase-Producing Acinetobacter baumannii in Wound Infections, Ghana, 2017/2018none
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/11795-5
dc.type.versionpublishedVersionnone
local.edoc.container-titleMicroorganismsnone
local.edoc.container-issn2076-2607none
local.edoc.pages10none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.mdpi.com/journal/microorganismsnone
local.edoc.container-publisher-nameMDPInone
local.edoc.container-volume9none
local.edoc.container-issue3none
local.edoc.container-reportyear2021none
dc.description.versionPeer Reviewednone

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