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2021-03-11Zeitschriftenartikel
Identification of two novel hepatitis C virus subtype 2 from Tunisia (2v and 2w)
dc.contributor.authorRajhi, Mouna
dc.contributor.authorHaddad-Boubaker, Sondes
dc.contributor.authorChouikha, Anissa
dc.contributor.authorBourquain, Daniel
dc.contributor.authorMichel, Janine
dc.contributor.authorHammami, Walid
dc.contributor.authorSadraoui, Amel
dc.contributor.authorTouzi, Hinda
dc.contributor.authorGhedira, Kais
dc.contributor.authorTriki, Henda
dc.date.accessioned2024-07-23T14:11:46Z
dc.date.available2024-07-23T14:11:46Z
dc.date.issued2021-03-11none
dc.identifier.other10.1371/journal.pone.0248249
dc.identifier.urihttp://edoc.rki.de/176904/11813
dc.description.abstractBackground Hepatitis C virus (HCV) has a high genetic diversity. Eight genotypes and 90 subtypes are currently described. Genotypes are clinically significant for therapeutic management and their determination is necessary for epidemiological studies. Methods Tunisian patients plasma samples (n = 6) with unassigned HCV-2 subtype using partial sequencing in the NS5B and Core/E1 regions were analyzed by realizing whole-genome sequencing analysis. Phylogenetic analyses were performed to assign subtypes. Results Phylogenetic analysis of the full genome sequences of Tunisian strains shows two subtypes within HCV-2. These later were genetically distinct from all previously established HCV-2 subtypes with nucleotide divergence greater than 15% (20% -31%). These two subtypes are proposed as new subtypes 2v and 2w. Conclusions The discovery of two new HCV-2 subtypes circulating in the Tunisian population confirms the great diversity of HCV-2 viruses and increases the total number of HCV-2 subtypes from 21 to 23.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleIdentification of two novel hepatitis C virus subtype 2 from Tunisia (2v and 2w)none
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/11813-4
dc.type.versionpublishedVersionnone
local.edoc.container-titlePLOS ONEnone
local.edoc.container-issn1932-6203none
local.edoc.pages11none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://journals.plos.org/plosone/none
local.edoc.container-publisher-namePLOSnone
local.edoc.container-reportyear2021none
dc.description.versionPeer Reviewednone

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