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2021-03-24Zeitschriftenartikel
Comparative in silico genome analysis of Clostridium perfringens unravels stable phylogroups with different genome characteristics and pathogenic potential
dc.contributor.authorAdbel-Glil, Mostafa Y.
dc.contributor.authorThomas, Prasad
dc.contributor.authorLinde, Jörg
dc.contributor.authorBusch, Anne
dc.contributor.authorWieler, Lothar H.
dc.contributor.authorNeubauer, Heinrich
dc.contributor.authorSeyboldt, Christian
dc.date.accessioned2024-07-26T13:58:10Z
dc.date.available2024-07-26T13:58:10Z
dc.date.issued2021-03-24none
dc.identifier.other10.1038/s41598-021-86148-8
dc.identifier.urihttp://edoc.rki.de/176904/11864
dc.description.abstractClostridium perfringens causes a plethora of devastating infections, with toxin production being the underlying mechanism of pathogenicity in various hosts. Genomic analyses of 206 public-available C. perfringens strains´ sequence data identified a substantial degree of genomic variability in respect to episome content, chromosome size and mobile elements. However, the position and order of the local collinear blocks on the chromosome showed a considerable degree of preservation. The strains were divided into five stable phylogroups (I–V). Phylogroup I contained human food poisoning strains with chromosomal enterotoxin (cpe) and a Darmbrand strain characterized by a high frequency of mobile elements, a relatively small genome size and a marked loss of chromosomal genes, including loss of genes encoding virulence traits. These features might correspond to the adaptation of these strains to a particular habitat, causing human foodborne illnesses. This contrasts strains that belong to phylogroup II where the genome size points to the acquisition of genetic material. Most strains of phylogroup II have been isolated from enteric lesions in horses and dogs. Phylogroups III, IV and V are heterogeneous groups containing a variety of different strains, with phylogroup III being the most abundant (65.5%). In conclusion, C. perfringens displays five stable phylogroups reflecting different disease involvements, prompting further studies on the evolution of this highly important pathogen.eng
dc.language.isoengnone
dc.publisherRobert Koch-Institut
dc.rights(CC BY 3.0 DE) Namensnennung 3.0 Deutschlandger
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/de/
dc.subject.ddc610 Medizin und Gesundheitnone
dc.titleComparative in silico genome analysis of Clostridium perfringens unravels stable phylogroups with different genome characteristics and pathogenic potentialnone
dc.typearticle
dc.identifier.urnurn:nbn:de:0257-176904/11864-1
dc.type.versionpublishedVersionnone
local.edoc.container-titlescientific reportsnone
local.edoc.container-issn2045-2322none
local.edoc.pages15none
local.edoc.type-nameZeitschriftenartikel
local.edoc.container-typeperiodical
local.edoc.container-type-nameZeitschrift
local.edoc.container-urlhttps://www.nature.com/srep/none
local.edoc.container-publisher-nameSpringer Naturenone
local.edoc.container-volume11none
local.edoc.container-reportyear2021none
dc.description.versionPeer Reviewednone

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